| Project/Area Number |
13670081
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | University of Yamanashi Faculty of Medicine |
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Principal Investigator |
HASHIMOTO Keitaro University of Yamanashi Faculty of Medicine, Professor, 医学部, 教授 (10004665)
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| Co-Investigator(Kenkyū-buntansha) |
KOMORI Sadayoshi Nirasaki Shimin Hospital, Vise director, 副院長 (30162069)
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| Project Period (FY) |
2001 – 2002
|
| Project Status |
Completed (Fiscal Year 2002)
|
| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2002: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2001: ¥2,700,000 (Direct Cost: ¥2,700,000)
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| Keywords | Na / H exchange / Ca exchange / arrhythmia / ischemia / sudden cardiac death / arrhythmia model |
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| Research Abstract |
Na/H exchange inhibitors have been shown by us and by others to suppress ischemia/reperfusion arrhythmias in rats and dogs, to improve hemodynamic recovery and to decrease infarct size. We confirmed again the effectiveness of Na/H exchange inhibition using a new drug, FR168888. This protective effect also involve Na/Ca exchange inhibition, but a new Na/Ca exchange inhibitor, SEA0300, did not show protection against ischemia/reperfusion arrhythmias. Since SEA0300 suppressed digitalis arrhythmias, which is thought to be due to Ca overload, further investigation is necessary to clarify in vivo mechanism of action of SEA0300.
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