Effects of atrial muscle structure on the initiation mechanism of atrial fibrillation and its drug therapy

Research Project

Project/Area Number	13670083
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	General pharmacology
Research Institution	Shinshu University
Principal Investigator	HIROSE Masamichi Shinshu University School of Medicine, Assistant Professor, 医学部, 講師 (40273081)
Project Period (FY)	2001 – 2002
Project Status	Completed (Fiscal Year 2002)
Budget Amount *help	¥4,100,000 (Direct Cost: ¥4,100,000) Fiscal Year 2002: ¥1,400,000 (Direct Cost: ¥1,400,000) Fiscal Year 2001: ¥2,700,000 (Direct Cost: ¥2,700,000)
Keywords	PACAP / Atrial muscle structure / Atriai fibrillation / Action potential / E-4031 / Zatebradine / Autonomic nervous system / カルシウムチャンネル / カリウムチャンネル / 過分極活性化電流 / 心房細動 / 活動電位幅 / 光学マッピング
Research Abstract	In isolated arterially perfused canine atria, transmural repolarization gradients were observed using high resolution optical mapping techniques to measure action potentials from the epicardial and endocardial surface on the right at rial free wall. These are performed during control conditions, during electrical stimulation of the fat pad at the right pulmonary vein-atrial junction (i.e. intracardiac parasympathetic stimulations) and during acetylcholine (ACh) infusion. Transmural repolarization gradients did not increase during intracardiac parasympathetic stimulation and during ACh infusion compared to during control. During ACh infusion, at rial tachyarrhythmia (AT) was initiated with a single premature stimulus and was associated with a focal pattern of activation (84 %). Importantly, AT initiation during intracardiac parasympathetic stimulations was also associated with the focal pattern of activity (36 %) without conduction block when repolarization gradients were small. During … More