| Project/Area Number |
13670104
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Kobe Pharmaceutical University |
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Principal Investigator |
SUGIMOTO Yumi Kobe Pharmaceutical University, lecturer, 薬学部, 講師 (50187671)
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| Project Period (FY) |
2001 – 2003
|
| Project Status |
Completed (Fiscal Year 2003)
|
| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 2003: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2002: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2001: ¥900,000 (Direct Cost: ¥900,000)
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| Keywords | anxiolytic / antidepressant / blood glucose / serotonin / stress / insulin / ストレス |
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| Research Abstract |
It is well known that serotonin is involved in psychiatric disorders and drugs affecting serotonertic neurotransmission are widely used for therapy of anxiety or depression. Effects of the serotonergic anxiolytics buspirone and tandospirone on plasma glucose and hyperglycemia elicited glucose, stress and epinephrine were studied in mice. Both buspirone and tandospirone significantly reduced glucose-, stress-and epinephrine-induced hyperglycemia and enhanced insulin release. This suggests that buspirone and tantospirone enhances insulin release, resulting in inhibition of hyperglycemia. The major metabolite of buspirone and tantospirone, 1-(2-pyrimidinyl)piperazine(1-PP) increased serum insulin levels and inhibited hyperglycemia. These results suggest that serotonergic anxiolytics, buspirone and tandospirone may be useful in the controlling glucose regulation as well as anxiety. Effects of tricyclic antidepressants, imipramine and clomipramine on plasma glucose levels were also investigated in mice. Imipramine and clomirpamine i.p. induced a dose-dependent hyperglycemia. We found that imipramine and clomipramine-induced hyperglycemia in mice are related to there inhibition of the central 5-HT_<2C> receptor. Since imipramine and clomipramine are commonly used in depression, present results indicate that attention should be paid for administration of these antidepressants in depression with diabetes mellitus.
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