| Project/Area Number |
13670257
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
寄生虫学(含医用動物学)
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| Research Institution | University of Occupational and Environmental Health |
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Principal Investigator |
KANAZAWA Tamotsu University of Occupational and Environmental Health, School of Medicine Professor, 医学部, 教授 (10194888)
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| Co-Investigator(Kenkyū-buntansha) |
OSADA Yoshio University of Occupational and Environmental Health, School of Medicine assistant professor, 医学部, 講師 (80282515)
ASAHI Hiroko National Institute of Infectious Diseases senior researcher, 寄生動物部, 主任研究官 (90231109)
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| Project Period (FY) |
2001 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2002: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2001: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | Schistoma haematobium / carcinogenesis / mutagenicity / umu test / HGPRT / Schistosoma haematobium |
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| Research Abstract |
There is a positive geographical relationship between the prevalence of Schistosoma haematobium infection (urinary schistosomiasis) and the incidence of squamous cell carcinoma of the urinary bladder. However, the mechanisms of oncogenesis in the urinary schistosomiasis-induced cancer are not fully understood. Here we investigated the mutagenicity of extracts of S. haematobium adult worms and eggs. In umu test, which can be used to test histidine-containing crude samples, we observed no mutagenicity of worms and eggs. In V79/HGPRT mutation assay, we observed slight increase of mutant cell colonies in worm extract treated group in the presence of S9 mix. However, this increase was too small to conclude that there was mutagenicity in the worm extract. Collectively, if any, there seems to be very little mutagenic substances in the S. haematobium worms and eggs.
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