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The control of bacterial infectious diseases by the hamony of immune system and nerve system

Research Project

Project/Area Number 13670261
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Bacteriology (including Mycology)
Research InstitutionHirosaki University

Principal Investigator

NAKANE Akio  Hirosaki University, School of Medicine, Professor, 医学部, 教授 (30164239)

Co-Investigator(Kenkyū-buntansha) MIURA Tomisato  Hirosaki University, School of Medicine, Lecturer, 医学部, 講師 (20261456)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2002: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2001: ¥2,800,000 (Direct Cost: ¥2,800,000)
KeywordsListeria monocytogenes / Sympathetic nerve system / Epinephrine receptor / MIF / IFN-gamma / TNF-alpha / IL-10 / Cortisol / 下垂体 / 神経系 / 細菌感染
Research Abstract

The host defense mechanism against bacterial infections through catecholamine receptors was investigated. Furthermore, the role of macrophage migration inhibitory factor (MIF), which is known to mediate the crosstalk between immune system and nerve system, in bacterial infections was investigated.
1. The regulatory mechanism by catecholamines in host defense against bacterial infections. The in vivo effects of antagonists and agonists to epinephrine receptors on host defense against Listeria monocytgenes infection and cytokine responses were investigated. When epinephrine receptor α antagonists were injected into mice, antilisterial resistance and productions of IFN-γ and TNF-α were suppressed. In contrast, epimephrine receptor β antagonists revealed no significant effect on antilisterial resistance and the cytokine production. These results suggest that antilisterial resistance and productions of IFN-γ and TNF-α may be regulated by epinephrine receptor α.
2. The role of MIF in bacterial … More infections (1) Endogenous MIF levels in the infected organs were up-regulated by a lethal infection with L. monocytogenes. The administration of anti-MIF antibody into mice showed no significant effect on the fate of a sublethal infection with L. monocytogenes, whereas the antibody rescued the mice from a lethal infection with L. monocytogenes. (2) Endogenous IFN-γ and TNF-α production in the infected organs was up-regulated in the early phase but down-regulated in the late phase of lethal infection in anti-MIF antibody-treated mice. (3) Endogenous IL-10 production in the livers was up-regulated in anti-MIF antibody-treated mice. Abnormality of liver function was partially restored by the administration of anti-IL-10 antibody in anti-MIF antibody-treated mice. (4) The level of plasma cortisol was significantly low in anti-MIF antibody-treated mice, compared with that of the normal rabbit globulin-treated mice.
These results suggest that MIF is involved in the pathogensis of a lethal infection with L. monocytogenes through the regulation of IL-10 production. Less

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (18 results)

All Other

All Publications (18 results)

  • [Publications] Tomisato Miura: "Effect of 6-hydroxydopamine on host resistance against Lisieria monocytogenes infection"Infection and Immunity. 69・12. 7234-7241 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Suguru Hasegawa: "Dysregulation of interleukin-10 and interleukin-12 are involved in the reduced host resistance to Listeria monocytogenes infection in alymphoplastic aly mutant mice"FEMS Immunology and Medical Microbiology. 32・3. 111-117 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sanae Sasaki: "Role of gamma interferon and tumor necrosis factor-alpha in shiga toxin lethality"Microbial Pathogenesis. 33・1. 43-47 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Mayuko Mizuki: "Comparison of host resistance to primary and secondary Listeria monocytogenes infections in mice by intranasal and intravenous routes"Infection and Immunity. 70・9. 4805-4811 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hiroshi Sashinami: "Effective induction of acquired resistance to Listeria monocytogenes by immunizing mice with in vivo-infected dendritic cells"Infection and Immunity. 71・1. 117-125 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Dong-Liang Hu: "Induction of emetic response to staphylococcal enterotoxins in the house Musk Shew (Suncus murinus)"Infection and Immunity. 71・1. 567-570 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Miura T, Kudo A, Matsuki A, Sekikawa K, Tagawa Y, Iwakura Y, Nakane A.: "Effect of 6-hydrpxydopamine on host resistance against Listeria monocytogenes infection"Infection and Immunity. 69-12. 7234-7241 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hasegawa S, Miura T, Sasaki S, Madarame H, Nakane A.: "Dys-regulation of interleukin-10 and interleukin-12 are involved in the reduced host resistance to Listeria monocytogenes infection in alymphocytic aly mutant mice"FEMS Immunology and Medical Microbiology. 32-2. 111-117 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sasaki S, Omoe K, Tagawa Y, Iwakura Y, Sekikawa K, Shinagawa K, Nakane A.: "Roles of gamma interferon and tumor necrosis factor-alpha in shiga toxin lethality"Microbial Pathogenesis. 33-1. 43-47 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Mizuki M, Nakane A, Sekikawa K, Tagawa Y, Iwakura Y.: "Comparison of host resistance to primary and secondary Listeria monocytogenes infections in mice by intranasal and intravenous routes"Infection and Immunity. 70-9. 4805-4811 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sashinami H, Nakane A, Iwakura Y, Sasaki M.: "Effective induction of acquired resistance to Listeria monocytogenes by immunizing mice with in vivo-infected dendritic cells"Infection and Immunity. 71-1. 117-125 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hu D-I, Omoe K, Shimada Y, Nakane A, Shiangawa K.: "Induction of emetic response to staphylococcal enterotoxins in the house musk Shew (Surcus murinus)"Infection and Immunity. 71-2. 690-696 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Dong-Liang Hu: "Induction of emetic response to staphylococcal enterotoxins in the house Musk Shew(Suncus murinus)"Infection and Immunity. 71・1. 567-570 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hiroshi Sashinami: "Effective induction of acquired resistance to Listeria monocytogenes by immunizing mice with in vivo-infected dendritic cells"Infection and Immunity. 71・1. 117-125 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Mayuko Mizuki: "Comparison of host resistance to primary and secondary Listeria monocytogenes infections in mice by intranasal and intravenous routes"Infection and Immunity. 70・9. 4805-4811 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Sanae Sasaki: "Role of gamma interferon and tumor necrosis factor-alpha in shiga toxin lethality"Microbial Pathogenesis. 33・1. 43-47 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Tomisato Miura: "Effect of 6-hydroxydopamine of host resistance against Listeria monocytogenes infection"Infection and Immunity. 69・12. 7234-7241 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] S.Hasegawa: "Dysregulation of interleukin-10 and interleukin-12 are involved in the reduced host resistance to Listeria monocytogenes infection in alymphoplastic aly mutant mice"FEMS Immunology and Medical Microbiology. 32・3. 111-117 (2002)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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