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Filamentous bacteriophages associated with recent pandemic strains of Vibrio parahaemolyticus

Research Project

Project/Area Number 13670271
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Bacteriology (including Mycology)
Research InstitutionOsaka University

Principal Investigator

IIDA Tetsuya  Osaka Univ., Research Institute for Microbial Diseases, Associate Professor, 微生物病研究所, 助教授 (90221746)

Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥4,100,000 (Direct Cost: ¥4,100,000)
Fiscal Year 2002: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 2001: ¥2,100,000 (Direct Cost: ¥2,100,000)
KeywordsVibrio parahaemolyticus / pandemic / filamentous bacteriophage / 繊維状ファージ
Research Abstract

In a previous study, we reported on a filamentous bacteriophage, f237, that is specifically associated wit the recent pandemic 03:K6 serovar strains of Vibrio parahaemolyticus. In this study, we examined distribution of the phage among clinical V. parahaemolyticus strains and characterized the phage itself. The followings are what we have obtained during this research term.
1. We examined the distribution of f237 among more recent clinical V. parahaemolyticus, and revealed that f237 is associated with not only 03:K6 serovar strains, but also other recent pandemic strains with serovar 04:K68 or 01:KUT. These results suggest that f237 is related to newly emerged pandemic strains of V. parahaemolyticus (Emerg. Infect. Dis. 7: 477-478, 2001).
2. We demonstrated that f237 is integrated into the host bacterial chromosome. Also we precisely determined the integration site of the phage (J. Bacteriol. 184: 4933-4935, 2002. Lancet 361: 743-749, 2003).
3. From the non-pandemic V. parahaemolyticus strains, we isolated two filamentou.s bacteriophages that are related to f237, and determined the whole genome sequences of the phages (manuscript in preparation).
4. We identified a new genetic marker of the pandemic V. parahaemolyticus strains (manuscript in preparation).

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (18 results)

All Other

All Publications (18 results)

  • [Publications] Iida et al.: "Filamentous phage associated with recent pandemic strains of Vibrio parahaemolyticus"Emerg. Infect. Dis.. 7. 477-478 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tagomori et al.: "Comparison of genome structures of vibrios, bacteria possessing two chromosomes"J. Bacteriol.. 184. 4351-4358 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Iida et al.: "Filamentous bacteriophages of vibrios are integrated into the dif-like site of the host chromosome"J. Bacteriol.. 184. 4933-4935 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Makino et al.: "Genome sequence of Vibrio parahaemolyticus : a pathogenic mechanism distinct from that of V cholerae"Lancet. 361. 743-749 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 飯田哲也(共著): "感染症研究のいま"大阪大学出版会. 90 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Iida, T., Hattori, A., Tagomori, K., Nasu, H., Naim, R., and Honda, T.: "Filamentous phage associated with recent pandemic strains of Vibrio parakaemolyticus"Emerg. Infect. Dis.. 7. 477-478 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tagomori, K., Iida, T., and Honda, T.: "Comparison of genome structures of vibrios, bacteria possessing two chromosomes"J. Bacteriol.. 184. 4351-4358 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Iida, T., Makino, K., Nasu, H., Yokoyama, K., Tagomori, K., Hattori, A., Okuno, T., Shinagawa, H., and Honda, T.: "Filamentous bacteriophages of vibrios are integrated into the diflike site of the host chromosome"J. Bacteriol.. 184. 4933-4935 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Makino, K., Oshima, K., Kurokawa, K., Yokoyama, K., Uda, T., Tagomori, K., Iijima, Y., Najima M., Nakano, M., Yamashita, A., Kubota, Y., Kimura, S., Yasunaga, T., Honda, T., Shinagawa, H., Hattori, M. and Iida, T.: "Genome sequence of Vibrio parahaemolyticus : a pathogenic mechanism distinct from that of V cholerae"Lancet. 361. 743-749 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tagomori et al.: "Comparison of genome structures of vibrios, bacteria possessing two chromosomes"J.Bacteriol. 184・16. 4351-4358 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Iida et al.: "Filamentous bacteriophages of vibrios are integrated into the dif-like site of the host chromosome"J.Bacteriol. 184・17. 4933-4935 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Makino et al.: "Genome sequence of Vibrio parahaemolyticus : a pathogenic mechanism distinct from that of V. cholerae"Lancet. 361. 743-749 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] 飯田 哲也(共著): "感染症研究のいま"大阪大学出版会. 90 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Takahashi et al.: "Chloride secretion induced by thermostable direct haemolysin of Vibrio parahaemolyticus-"J. Med Microbiol. 50. 870-878 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Murata et al.: "A large outbreak of foodborne infection attributed to Providencia alcalifaciens"J. Infect. Dis.. 184. 1050-1055 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Nakano et al.: "Association of the urease gene with enterohemorrhagic E. coli strains-"J. Clin. Microbiol. 39. 4541-4543 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Akeda et al.: "Dominant negative Rho, Rac, and Cdc42 facilitate the invasion…"Infect. Immun.. 70. 970-973 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Iida et al.: "Filamentous phaqe associated with recent pandemic strains of Vibrio parahaemolyticus"Emerg. Infect. Dis.. 7. 477-478 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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