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Association of anti-oxidant vitamins and C-reactive protein with non-invasive brachial-ankle pulse wave velocity and ankle -brachial index in Japanese middle-aged male workers

Research Project

Project/Area Number 13670360
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Public health/Health science
Research InstitutionSHIGA UNIVERSITY OF MEDICAL SCIENCE

Principal Investigator

OKAMURA Tomonori  Shiga University of Medical Science, Department of Health Science, Associate Professor (00324567)

Co-Investigator(Kenkyū-buntansha) UESHIMA Hirotsugu  Shiga University of Medical Science, Department of Health Science, Professor (70144483)
KADOWAKI Takashi  Shiga University of Medical Science, Department of Health Science, Research Associate (30324578)
MORIYAMA Yuri  Public Health Institute of Kochi Prefecture, Chife Researcher
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 2002: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2001: ¥1,100,000 (Direct Cost: ¥1,100,000)
KeywordsC-reactive protein / brachial-ankle pulse wave velocity / alpha-tocopherol / folate / vitamin B12 / drinking / smoking / ankle-brachial index / 高感度C反応性蛋白(hs-CRP) / 容積脈波(PWV) / アルコール(飲酒) / BMI / 食生活 / C反応性蛋白(CRP) / 生活習慣
Research Abstract

Pulse wave velocity (PWV) is an indicator of arterial stiffness, especially in aorta, and a marker for vascular damage. We examined the association of brachial-ankle PWV (baPWV) with serum alpha-tocopherol and C-reactive protein (CRP) levels in addition to the traditional risk factors. Study subjects comprised of 178 Japanese male workers aged 50-59 without past histories of cardiovascular diseases. The relation of baPWV with serum alpha-tocopherol and CRP levels were cross-sectionally analyzed after adjusting for other cardiovascular risk factors. Arithmetic mean of serum alpha-tocopherol was 38.9"mol/L and geometric mean of serum CRP was 0.47mg/L. Multiple linear regression analysis indicated that serum CRP levels were associated with the elevation of baPWV, in addition to age, systolic blood pressure and heart rate. However, serum alpha-tocopherol, serum lipids (triglyceride, low and high density lipoprotein cholesterol), fasting plasma glucose, body mass index, smoking and alcohol drinking did not significantly correlate to baPWV. Multivariate adjusted means of baPWV according to serum CRP quartile were 1431, 1436, 1507 and 1508 [cm/sec] (P=0.033). Serum CRP level might be an important marker for arterial stiffness in Japanese middle-aged males. However, the relation of alpha-tocopherol and other anti-oxidant vitamins to baPWV was not evident.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (10 results)

All 2004 2001 Other

All Journal Article (4 results) Publications (6 results)

  • [Journal Article] Non-invasive measurement of brachial-ankle pulse wave velocity associated with serum C-reactive protein but not with alpha-tocopherol in Japanese middle-aged male workers2004

    • Author(s)
      Okamura T, Moriyama Y, et al.
    • Journal Title

      Hypertension Research 27(3)予定(印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Title of article; Non-invasive measurement of brachial-ankle pulse wave velocity associated with serum C-reactive protein but not with alpha-tocopherol in Japanese middle-aged male workers2004

    • Author(s)
      Tomonori Okamura, Yuri Moriyama, Takashi Kadowaki, Hideyuki Kanda, Yoshikuni Kita, Hirotsugu Ueshima.
    • Journal Title

      Hypertension Research Vol.27(3)(in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] 血中ホモシステイン、葉酸、ビタミンB12と動脈硬化の関連2001

    • Author(s)
      森山ゆり
    • Journal Title

      Vitamin Information Center News Letter 103

      Pages: 1-2

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Title of article ; Association of homocysteine, folate, vitamin B12 with atherosclerosis (in Japanese)2001

    • Author(s)
      Yuri Moriyama, Tomonori Okamura.
    • Journal Title

      Vitamin Information Center Newsletter 103

      Pages: 1-2

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 岡村智教, 森山ゆり: "キーワード解説;ホモシステイン値"動脈硬化予防. 1巻2号. 104-105 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 岡村智教: "アルコールと動脈硬化性疾患"動脈硬化予防. 1巻3号. 106-110 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] 森山ゆり: "血中ホモシステイン、葉酸、ビタミンB12と動脈硬化の関連"Vitamin Information Center News Letter. 103. 1-2 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Moriyama Y, Okamura T, et al.: "Japanese Journal of Cardiovascular Disease Prevention"Lifestyle-related determinants for serum folate, vitamin B12 and B6 affecting to plasma level of homocysteine in Japan. 36. 93 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] 森山ゆり, 岡村智教: "本邦における血中ホモシステインおよび関連ビタミン濃度を規定する生活習慣に関する検討"動脈硬化. 29. 228 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Moriyama Y, Okamura T, Kajinami K, et al.: "Effect of serum B vitamins on elevated plasma homocysteine levels associated with the mutation of methylenetetrafolate reductase gene in Japanese"Atherosclerosis. (in press). (2002)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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