| Project/Area Number |
13670368
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Ehime University |
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Principal Investigator |
KONISHI Masamitsu Ehime University, Faculty of Medicine, professor, 医学部, 教授 (40274328)
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| Co-Investigator(Kenkyū-buntansha) |
OKADA Katsutoshi Ehime University, Faculty of Medicine, instructor, 医学部, 助手 (10314949)
FUJIMOTO Koichiro Ehime University, Faculty of Medicine, instructor, 医学部, 助手 (30243778)
KATO Tadahiro Ehime University, Faculty of Medicine, associate professor, 医学部, 助教授 (60325363)
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| Project Period (FY) |
2001 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥4,100,000 (Direct Cost: ¥4,100,000)
Fiscal Year 2002: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 2001: ¥2,300,000 (Direct Cost: ¥2,300,000)
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| Keywords | Carotid sonography / Cerebro-vascular disease / exercise / share rate / atherosclerosis / flowcyte-meter / ズリ応力比 |
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| Research Abstract |
In Japan, recently, the feature of the cerebro vascular disease (CVD) has been changed, largely due to the measures of preventive CVD and the changes from Japanese traditional lifestyles to westernized lifestyles, including diet and working. At present, however, the morbidity and mortality of brain stroke were more frequent than North Americans and Europeans. The aim of this study was to investigate new methods of the prevention of the cardiovascular disease.
In this study, the activation of IL-6 receptor was association with the plaque indexes of the carotid ultrasonography. And increase of the share rate was association with plaques. This result shows that mechanical function of blood flow irritates the atherosclerotic changes through of the immuno-inflammation responses. By the case-control study, there was significantly relation between indexes of carotid ultrasonography and brain infarction. But there were some limits about this result. The association with the lacunar infarction was slightly below that of the large artery infarction. Moreover, among Japanese, the measurement of the carotid ultrasonography simultaneously with the IL-6 should be emphasized for screening method of the brain infarction.
The other analysis of this study, the exercise was negative association with atherosclerotic changes of the carotid artery. There for, the preserving exercise was the measure of preventive atherosclerosis and CVD.
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