• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Analyses of SNPs on various human gene loci and their forensic applications

Research Project

Project/Area Number 13670440
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Legal medicine
Research InstitutionKURUME UNIVERSITY

Principal Investigator

KODA Yoshiro  Forensic Medicine and Human Genetics, Kurume University School of Medicine, Associate Professor, 医学部, 助教授 (90231307)

Co-Investigator(Kenkyū-buntansha) SOEJIMA Mikiko  Forensic Medicine and Human Genetics, Kurume University School of Medicine, Research Associate, 医学部, 助手 (80279140)
KIMURA Hiroshi  Forensic Medicine and Human Genetics, Kurume University School of Medicine, Professor, 医学部, 教授 (20112039)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2002: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 2001: ¥2,100,000 (Direct Cost: ¥2,100,000)
KeywordsKEL / α(1, 4)glactosyltransferase gene / PON1 / BRCA1 / SNP / linkage disequilibrium (LD) / FUT2 / linkage disequilibrium(LD) / SNPs / P blood group
Research Abstract

We reported the null mutations for P blood group and KEL blood group. We also reported that human phosphoglucomutase 3 is identical to N-acetylglucosamine-phosphate mutase1. In addition, we examined DNA sequence variation both in a 1.3-kb promoter region 16.5 kb away from codon 192 and in a 1.7-kb region centered on the 192Q/R polymorphic site of the coding region of PON1. The number of pairs of polymorphic sites between the promoter and 1.7-kb regions that were in significant linkage disequilibrium was much higher in a Japanese population than in African and European populations. In addition, the pairs of polymorphic sites in linkage disequilibrium differed among the three populations. These results suggest that some of the population differences in association with risk for coronary heart disease can be explained by population differences in haplotype frequency of PON1 haplotypes (submitted). We found a polymorphic novel short tandem repeat located 1.8 kb downstream of the last exon of the human secretor gene (FUT2). Sequencing analysis of the STR locus revealed high microvariation both in Xhosan and Caucasian populations, whereas exhibited simple repeat structure in Japanese population. Linkage disequilibrium between the human secretor FUT2 and the FUT2/01 loci was observed. In addition, the Xhosan population has high levels of haplotype diversity and share haplotypes both from Caucasian and Japanese populations (submitted). We also examined the largest coding exon (exon 11) (about 3.4 kb) of the BRCA1 for allelic polymorphism by direct sequencing in human and chimpanzee populations. The results suggested that a kind of selection, population structure and/or population bottleneck might be responsible for the generation of the BRCA1 polymorphism.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (31 results)

All Other

All Publications (31 results)

  • [Publications] H.Pang: "N-acetylglucosamine-phosphate mutase genotype and diabetic microvascular complications"Diabetic Med. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] S.Yamagishi: "PEDF Met72Thr polymorphism in patients with diabetic microangiopathy"Int. J. Clin. Pharm. Res. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] M.Tsuneoka: "A novel Myc target gene, mina53, that is involed in cell proliferation"J. Biol. Chem. 277. 35450-35459 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] H.Pang: "Identification of human phosphoglucomutase 3 (PGM3) as N-acetylglucosamine-phosphate mutase (AGM1)"Ann. Hum. Genet. 66. 139-144 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Y.Koda: "Haptoglobin genotype and diabetic microangiopathies it Janpanese diabetic patients"Diabetologia. 45. 1039-1040 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] B.Wang: "Polymorphisms of eight STR loci in Chinese and African (Xhosa) populations"Forensic Sci Int. 125. 279-280 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Y.Koda: "Three-base deletion and one-base insertion of the α(1.4)galactosyltransferase gene responsible for the p phenotype"Transfusion. 42. 48-51 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Y.Koda: "Heterozygosity for two novel alleles of the KEL gene causes the Kell-null phenotyne in a Japanese woman"Br. J. Haematol. 117. 220-225 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] K.Nakayama: "Distinctive distribution of AIM1 polymorphism among major human populations with different skin color"J. Hum. Genet. 47. 92-94 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] H.Pang: "Polymorphism of the human ABO-Secretor locus (FUT2) in four populations in Asia : indication of distinct Asian subpopulations"Ann. Hum. Genet. 65. 429-437 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] H. Pang: "N-acetylglucosamine-phosphate mutase genotype and diabetic microvascular complications"Diabetic Med.. in press.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] S. Yamagishi: "PEDF Met72Thr polymorphism in patients with diabetic microangiopathy"Int. J. Clin. Pharm. Res. in press.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] M. Tsuneoka: "A novel Myc target gene, mina53, that is involved in cell proliferation"J. Biol. Chem. 277. 35450-35459 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] H. Pang: "Identification of human phosphoglucomutas 3 (PGM3) as N-acetylglucosamine-phosphate mutase (AGM1)"Ann. Hum. Genet. 66. 139-144 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Y. Koda: "Haptoglobin genotype and diabetic microangiopathies in Japanese diabetic patients"Diabetologia. 45. 1039-1040 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] B. Wang: "Polymorphisms of eight STR loci in Chinese and African (Xhosa) populations"Forensic Sci. Int. 125. 279-280 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Y. Koda: "Three-base deletion and one-base insertion of the α(1, 4)galactosyltransferase gene responsible for the p phenotype"Transfusion. 42. 48-51 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Y. Koda: "Heterozygosity for two novel alleles of the KEL gene causes the Kell-null phenotype in a Japanese woman"Br. J. Haematol. 117. 220-225 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] K. Nakayama: "Distinctive distribution of AIM1 polymorphism among major human populations with different skin color"J. Hum. Genet. 47. 92-94 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] H. Pang: "Polymorphism of the human ABO-Secretor locus (FUT2) in four populations in Asia : indication of distinct Asian subpopulations"Ann. Hum. Genet. 65. 429-437 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] H.Pang: "N-acetylglucosamine-phosphate mutase genotype and diabetic microvascular complications"Diabetic Med. (in press).

    • Related Report
      2002 Annual Research Report
  • [Publications] S.Yamagishi: "PEDF Met72Thr polymorphism in patients with diabetic microangiopathy"Int.J.Clin.Pharm.Res. (in press).

    • Related Report
      2002 Annual Research Report
  • [Publications] M.Tsuneoka: "A novel Myc target gene, mina53, that is involed in cell proliferation"J.Biol.Chem. 277. 35450-35459 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] H.Pang: "Identification of human phosphoglucomutase 3(PGM3) as N-acetylglucosamine-phosphate mutase(AGM1)"Ann.Hum.Genet. 66. 139-144 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Y.Koda: "Haptoglobin genotype and diabetic microangiopathies in Japanese diabetic patients"Diabetologia. 45. 1039-1040 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] B.Wang: "Polymorphisms of eight STR loci in Chinese and African(Xhosa) populations"Forensic Sci.Int. 125. 279-280 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Y.Koda: "Three-base deletion and one-base insertion of the α(1,4)galactosyltransferase gene responsible for the p phenotype"Transfusion. 42. 48-51 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Y.Koda: "Heterozygosity for two novel alleles of the KEL gene causes the Kell-null phenotype in a Japanese woman"Br.J.Haematol. 117. 220-225 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] K.Nakayama: "Distinctive distribution of AIM1 polymorphism among major human populations with different skin color"J.Hum.Genet. 47. 92-94 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yoshiro Koda: "Contrasting patterns of polymorphisms at the ABO-Secretor gene (FUT2) and plasma α(1,3) fucosyltransferase gene (FUT6) in human population"Genetics. 158. 747-756 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Hao Pang: "Polymorphism of the human ABO-Secretor locus (FUT2) in four populations in Asia : indication of distinct Asian subpopulations"Ann Hum Genet. 65. 429-437 (2001)

    • Related Report
      2001 Annual Research Report

URL: 

Published: 2001-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi