| Project/Area Number |
13670483
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
内科学一般
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| Research Institution | St. Marianna University School of Medicine |
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Principal Investigator |
KATO Tomohiro St. Marianna University School of Medicine, Institute of Medical Science assistant professor, 難病治療研究センター, 助教授 (80233807)
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| Project Period (FY) |
2001 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2002: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 2001: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | anti-lymphocyte antibody / NK cell / killer immunoglobulin-like receptor / antibody / systemic lupus erythematosus / Killer cell Immunoglobulin-like Receptor / 慢性関節リウマチ / 強皮症 / 全身性エリテマトーデス / シェーグレン症候群 |
|---|
| Research Abstract |
We have been investigating so-called anti-lymphocyte antibodies, antibodies to cell surface molecules on the lymphocytes. In the present study, we tried to detect and analyze autoantibodies to killer immunoglobulin-like receptor 2 DL, one of the NK receptors. We here evidenced existence of autoantibodies to KIR2DL in rheumatoid arthritis, systemic lupus erythematosus, and Behcet's disease, where the existence was correlated with hyper-gamma-globulinemia. To further analyze mechanisms for this, we investigated the effects of the KIR2DL autoantibodies on the anti-cytotoxic activity of NK cells, however, the detected effects were different between the serum samples. Further more detailed analysis would be needed to elucidate the mechanisms.
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