| Project/Area Number |
13670521
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
|
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| Research Institution | Hiroshima University |
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Principal Investigator |
CHAYAMA Kazuaki Hiroshima University, Graduate School of Biomedical Science, Professor, 大学院・医歯薬学総合研究科, 教授 (00211376)
|
|---|
| Project Period (FY) |
2001 – 2003
|
| Project Status |
Completed (Fiscal Year 2003)
|
| Budget Amount *help |
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2003: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2002: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2001: ¥1,600,000 (Direct Cost: ¥1,600,000)
|
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| Keywords | hepatitis C virus / chronic hepatitis / acute hepatitis / full length clone / replicon / HCV infectiousclone / IFN-β / RNA interference / IRFファミリー / polymerase / helicase / protease / polymerase chain reaction |
|---|
| Research Abstract |
Hepatitis C virus infection is a serious health problem worldwide. As the hepatitis C virus infects only humans and chimpanzees, establishment of reliable culture system is necessary to study this important pathogen. We cloned a full length genotype 1b cDNA clone of the hepatitis C virus from a patient who developed acute hepatitis C. This cDNA clone was used to construct several replicon clones and infectious clones. These constructs should be useful to study the hepatitis C virus.
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