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Modulation of thymocyte development by estrogen and autoimmune hepatitis

Research Project

Project/Area Number 13670525
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionKochi medical School

Principal Investigator

ONISHI Saburo  Kochi medical School, First dept. Med., Professor, 医学部, 教授 (60136380)

Co-Investigator(Kenkyū-buntansha) SAIBARA Toshiji  Kochi medical School, First dept. Med., Assistant Professor, 医学部附属病院, 講師 (60145125)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2002: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2001: ¥2,100,000 (Direct Cost: ¥2,100,000)
Keywordsflowcytometry / aromatase / ArKO / CD25 / CD44 / estrogen / ArKO / thymocyte / auto immunity
Research Abstract

Thymic regression and reduced cellularity were evident in aromatase-deficient mice. The major difficulties in thymocyte development were observed during the CD44^+CD25^- stage at the cortico-medullary junction and during the CD44^-CD25^- stage at the subcapsular region. The expression of Smoothened of the Hedgehog signaling was enhanced in CD4^-CD8^- double negative cells. This enhancement may result in impaired progression of CD44^-CD25^- cells to the CD4^+CD8^+ double positive stage and impaired proliferation of CD4^+CD8^+ double positive cells. This could be the reason why the proportion of CD3^+TCRβ^<high> cells during the late phase of thymocyte maturation was reduced in ArKO mice.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (29 results)

All Other

All Publications (29 results)

  • [Publications] K.Toda, et al.: "Alterations in fatty-acid metabolism in the liver of ArKO male nice and their ameliorations by administration of 17 β -estradiol or a ligand of peroxisome proliferator-activated receptor α"J Steroid Biochem Mol Biol. 79. 11-17 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] C-L.Li, et al.: "Thymosin a 1 accelerates restoration of T cell-mediated neutralizing antibody response in immunocompromised hosts"Intern Immunopharmacol. 2. 39-46 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T.Saibara, et al.: "Low socioeconomic status and coronary artery disease"Lancet. 359. 980 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] C-L Li, et al.: "Estrogen deficiency results in enhanced expression of Smoothened of the Hedgehog signaling in the thymus and affects thymocyte development"Intern Immunopharmacol. 2. 823-833 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T.Yoshikawa, et al.: "Aromatase-deficient (ArKO) mice are retrieved from severe hepatic steatosis by peroxisome proliferator administration"Hepatol Res. 22. 278-287 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nemto Y, et al.: "Tamoxifen-induced nonalcoholic steatohepatitis in breast cancer patients"Intern Med. 41. 345-350 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Murata Y, et al.: "Tamoxifen-induced non-alcoholic steatohepatitis in patients with breast cancer : Determination of a suitable biopsy site for diagnosis"Oncology Rep. 10. 97-100 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T. Saibara, et al.: "Effects of ethanol on 1-arginine transport in rat ito cells in relation to nitric oxide production"Alcohol Clin Exp Res.. 25. 39S-45S (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] K. Toda, et al.: "Targeted disruption of the aromatase P450 gene (Cyp19) in mice and their ovarian and uterine responses to 17beta-oestradiol"J Endocrinol.. 170. 99-111 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] K. Toda, et al.: "Alterations in fatty-acid metabolism in the liver of ArKO male mice and their ameliorations by administration of 17 β-estradiol or a ligand of peroxisome proliferator-activated receptor α"J Steroid Biochem Mol Biol.. 79. 11-17 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] C-L. Li, et al.: "Thymosin al accelerates restoration of T cell-mediated neutralizing antibody response in immunocompromised hosts"Intern Immunopharmacol. 2. 39-46 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T. Saibara, et al.: "Low socioeconomic status and coronary artery disease"Lancet. 359. 980 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] C-L Li, et al.: "Estrogen deficiency results in enhanced expression of Smoothened of the Hedgehog signaling in the thymus and affects thymocyte development"Intern Immunopharmacol. 2. 823-833 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T. Yoshikawa, et al.: "Aromatase-deficient (ArKO) mice are retrieved from severe hepatic steatosis by peroxisome proliferator administration"Hepatol Res.. 22. 278-287 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nemto Y, et al.: "Tamoxifen-induced nonalcoholic steatohepatitis in breast cancer patients"Intern Med.. 41. 345-350 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Murata Y, et al.: "Tamoxifen-induced non-alcoholic steatohepatitis in patients with breast cancer : Determination of a suitable biopsy site for diagnosis"Oncology Rep.. 10. 97-100 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] K.Toda, et al.: "Alterations in fatty-acid metabolism in the liver of ArKO male mice and their ameliorations by administration of 17 β-estradiol or a ligand of peroxisome proliferator-activated receptor α"J Steroid Biochem Mol Biol. 79. 11-17 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] C-L.Li, et al.: "Thymosin a1 accelerates restoration of T cell-mediated neutralizing antibody response in immunocompromised hosts"Intern Immunopharmacol. 2. 39-46 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] T.Saibara, et al.: "Low socioeconomic status and coronary artery disease"Lancet. 359. 980 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] C-L.Li, et al.: "Estrogen deficiency results in enhanced expression of Smoothened of the Hedgehog signaling in the thymus and affects thymocyte development"Intern Immunopharmacol. 2. 823-833 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] T.Yoshikawa, et al.: "Aromatase-deflcient (ArKO) mice are retrieved from severe hepatic steatosis by peroxisome proliferator administration"Hepatol Res. 22. 278-287 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Nemto Y, et al.: "Tamoxifen-induced nonalcoholic steatohepatitis in breast cancer patients"Intern Med. 41. 345-350 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Murata Y, et al.: "Tamoxifen-induced non-alcoholic steatohepatitis in patients with breast cancer : Determination of a suitable biopsy site for diagnosis"Oncology Rep. 10. 97-100 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] K.Toda, et al.: "A loss of aggressive behaviour and its reinstatement by oestrogen in mice lacking the aromatase (cyp 19) gene"J Endocrinol. 168. 217-220 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] K.Toda, et al.: "Oestrogen at the neonatal stage is critical for the reproductive ability of male mice as revealed by supplementation with 17 β-estradiol to aromatase gene (Cyp19) knockout mice"J Endocrinol. 168. 455-463 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] K.Toda, et al.: "Targeted disruption of the aromatase P450 gene (Cyp19) in mice and their ovarian and uterine responses to 17beta-oestradiol"J Endocrinol. 170. 99-111 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] T.Saibara, et al.: "Effects of ethanol on I-arginine transport in rat ito cells in relation to nitric oxide production"Alcohol Clin Exp Res. 25. 39S-45S (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Okamoto N, et al.: "cDNA sequence of human carbonic anhydrase-related protein, CA-RP X : mRNA expressions of CA-RP X and XI in human brain"Biochim Biophys Acta.. 1518. 311-316 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Tsuda K, et al.: "Eosinophil-induced liver injury : an experimental model using IL-5 transgenic mice"J Hepatol.. 34. 270-277 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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