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Pathomechanisms of movement disorders related to epileptic excitation

Research Project

Project/Area Number 13670640
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurology
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

IKEDA Akio  Kyoto University, Graduate School of Medicine, Lecturer, 医学研究科, 講師 (90212761)

Co-Investigator(Kenkyū-buntansha) NAGAMINE Takashi  Kyoto University, Graduate School of Medicine, Associate Professor, 医学研究科, 助教授 (10231490)
MIYAMOTO Susumu  Kyoto University, Graduate School of Medicine, Associate Professor, 医学研究科, 助教授 (70239440)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 2002: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2001: ¥1,600,000 (Direct Cost: ¥1,600,000)
KeywordsEpileptic excitation / Epileptic inhibition / Supplementary motor area / Transcraial magnetic stimulation / Epileptic seizures / transcorical associaion / 脱力発作 / 経頭蓋的磁気刺激刺激法 / 皮質電気刺激法
Research Abstract

Epileptic inhibitory process causes so-called atonic seizures, and inhibitory mechanism within the normal cortices may be responsible for seizure inhibition. We investigated the pathomechanism of the two phenomena
(1) Atonic seizures in patients with partial epilepsy were investigated by means of prolonged video/EEG monitoring, MRI and FDG-PET. Rostral, non-primary motor area and perirolandic areas were responsible for developing atonic seizures in patients with partial epilepsy. As opposed to atonic seizures in generalized epilepsy in which a sudden atonia leads to the falling and significant trauma, atonic seizures in partial epilepsy developed not so suddenly and thus less severe trauma was caused. This difference could reflect the cortical involvement responsible for atonia in the cortical level. (2) Inhibitory effects on the epileptic foci by electrical or magnetic cortical stimulation: In order to clarify the degree of inhibitory effects and the mechanism on the epileptic foci by … More magnetic or electrical cortical stimulation, we first employed low-frequency (0.9Hz) electric stimulation through a pair of subdural electrodes in patients with intractable partial epilepsy who had chronic subdural implantation before epilepsy surgery. As the results, significantly interictal epileptiform discharges decreased when epileptic focus was stimulated. When epileptic foci were stimulated by means of high frequency elctric currents as done for usual cortical mapping, interictal epileptiform discharged also decreased and background power of ECoG also significantly decreased mainly between 20 to 40Hz selectively at the stimulated cortical area. It may reflect the augmentation of the intrinsic inhibitory mechanism. We also employed low-frequency (0.9Hz,15min, 4 times in a week) transcranial magnetic stimulation in patients with intractable neocortical epilepsy. As the results, habitual seizures decreased in the following 2 weeks after stimulation by 44%. Both epileptic and magnetic cortical stimulation can suppress inhibitory activity at least partly by means of common physiological mechanism Less

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (47 results)

All Other

All Publications (47 results)

  • [Publications] Nakamura M: "Automatic EEG interpretation adaptable to individual electroencephalographer using aritificial neural network"Int J A dapt Control Signal Process. 16. 25-37 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yamamoto J: "Low frequency electric cortical stimulation has an inhibitory effect on epileptic focus in mesial temporal lobe epilepsy"Epilepsia. 43. 491-495 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Satow T: "Partial epilepsy manifesting atonic seizure : report of two case"Epilepsia. 43. 1425-1431 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ikeda A: ""Supplementary motor area (SMA) seizure" rather than "SMA epilepsy" in optimal surgical candidates : a document of subdural recording"J Neurol Sci. 202. 43-52 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ihara M: "Neuroleptic malignant syndrome prolonged catatonia in a dopa-responsive dystonia patient"Neurology. 59. 1102-1104 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Satow T: "Nausea as a complication of low-frequency repetitive transcranial magnetic stimulation of the posterior fossa"Clin Neurophysiol. 113. 1441-1443 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hanakawa T: "Functional mapping of human medial frontal motor areas : a combined use of functional MRI and cortical stimulation"Exp Brain Res. 138. 403-409 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ikeda A: "Asymmetric tonic seizures with bilteral partietal lesions resembling frontal lobe epilepsy"Epileptic Disord. 3. 17-21 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ikeda A: "Hiccups start, seizures cease"Ann Neurol. 50. 128-129 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Bai O: "Markov process EEG model for spontaneous background activity"J Clin Neurophysiol. 18. 283-290 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Bai O: "Blink artifact elimination in electroencephalographic recordes based on discrete cosine transform domain modeling"Frontiers Med Biol Engng. 11. 191-206 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ohara S: "Increased synchronization of cortical oscillatory activities between human supplementary motor and primary sensorimotor area during voluntary movements"J Neurosci. 21. 9377-9386 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hanakawa T: "Functional mapping of human medial frontal motor areas: a combined use of functional MRI and cortical stimulation"Exp Brain Res. 138. 403-409 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ikeda A: "Asymmetric tonic seizures with bilteral partietal lesions resembling frontal lobe epilepsy"Epileptic Disord. 3. 17-21 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ikeda A: "Hiccups start, seizures cease"Ann Neurol. 50. 128-129 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Bai O: "Markov process EEG model for spontaneous background activity"J Clin Neurophysiol. 18. 283-290 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Bai O: "Blink artifact elimination in electroencephalographic recorder based on discrete cosine transform domain modeling"Frontiers Med Biol Engng. 11. 191-206 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ohara S: "Increased synchronization of cortical oscillatory activities between human supplementary motor and primary sensorimotor area during voluntary movements"J Neurosci. 21. 9377-9386 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakamura M: "Automatic EEG interpretation adaptable to individual electroencephalographer using aritificial neural network"Int J A dapt Control Signal Process. 16. 25-37 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yamamoto J: "Low frequency electric cortical stimulation has an inhibitory effect on epileptic focus in mesial temporal lobe epilepsy."Epilepsia. 43. 491-495 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Satow T: "Partial epilepsy manifesting atonic seizure: report of two case"Epilepsia. 43. 1425-1431 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ikeda A: ""Supplementary motor area (SMA) seizure" rather than "SMA epilepsy" in optimal surgical candidates: a document of subdural recording"J Neurol Sci. 202. 43-52 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ihara M: "Neuroleptic malignant syndrome with prolonged catatonia in a dopa-responsive dystonia patient"Neurology. 59. 1102-1104 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Satow T: "Nausea as a complication of low-frequency repetitive transcranial magnetic stimulation of the posterior fossa"Clin Neurophysiol. 113. 1441-1443 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakamura M et al.: "Automatic EEG interpretation adaptable to individual electroencephalographer using aritificial neural network"Int J Adapt Control Signal Process. 16. 25-37 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yamamoto J, et al.: "Low frequency electric cortical stimulation has an inhibitory effect on epileptic focus in mesial temporal lobe epilepsy"Epilepsia. 43. 491-495 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Satow T, et al.: "Partial epilepsy manifesting atonic seizure : report of two case"Epilepsia. 43. 1425-1431 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ikeda A, et al.: ""Supplementary motor area (SMA) seizure" rather than "SMA epilepsy" in optimal surgical candidates : a document of subdural recording"J Neurol Sci. 202. 43-52 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ihara M et al.: "Neuroleptic malignant syndrome with prolonged catatonia in a dopa-responsive dystonia patient"Neurology. 59. 1102-1104 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Satow T et al.: "Nausea as a complication of low-frequency repetitive transcranial magnetic stimulation of the posterior fossa"Clin Neurophysiol. 113. 1441-1443 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Usui K, et al.: "Conversion of semantic information into phonological representation : a function in left posterior temporal area"Brain. 126. 632-641 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yoshida K, et al.: "Movement-related cortical potentials before jaw excursions in oromandibular dystonia"Mov Disord. 18. 94-100 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hitomi T et al.: "Improvement of central motor conduction after bone marrow transplantation in adrenoleukodystrophy"J Neurol Neurpsurg Psych. 74. 373-375 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yamamoto J, et al.: "Seizures arising from the inferior parietal lobule can show ictal semiology of the second sensory seizures (Sll seizure)"J Neurol Neurpsurg Psych. 74. 367-369 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Satow T, et al.: "Mirth and laughter arising from human temporal cortex"J Neurol Neurpsurg Psych. (in press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Satow T, et al.: "Direct cortical area for motor preparation and execution in human identified by bereitschaftspotential recordng and ECoG-EMG coherenc"Clin Neurophysiol. (in press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Matsumoto R, et al.: "Functional subdivisions of human premotor cortex : epicortical recoroding in visiomotor task"Clin Neurophysiol. (in press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ikeda A, Klem GH, Luders HO: "Lippincott Williams & Wilkins, Philadelphia(分担執筆)"Diffuse encephalopathies. In : Ebersole JS and Pedley TA (eds) : Current practice of clinical electroencephalography, 3rd edition. 30 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ikeda A, et al.: "Asymmetric tonic seizures with bilateral parietal lesions resembling frontal lobe epilepsy"Epileptic Disord. 3. 17-21 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Ikeda A, et al.: "Hiccups start, seizures cease"Ann Neurol. 50. 128-129 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Ikeda A, et al.: "Motor inhibition by human supplementary motor area proper"Clin Neurophysiol. in press.

    • Related Report
      2001 Annual Research Report
  • [Publications] Hanakawa T, et al.: "Functional mapping of human medial frontal motor areas. The combined use offunctional magnetic resonance imaging and cortical stimulation"Exp Brain Res.. 138. 403-409 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yamamoto J, et al.: "Low frequency electric cortical stimulation has an inhibitory effect on epileptic focus in mesial temporal lobe epilepsy"Epilepsia. (in press).

    • Related Report
      2001 Annual Research Report
  • [Publications] Satow T, et al.: "Partial epilepsy manifesting atonic seizure : report of two case"Epilepsia. (in press).

    • Related Report
      2001 Annual Research Report
  • [Publications] Ohara S, et al.: "Increased synchronization of cortical oscillatory activities between human supplementary motor and primary sensorimotor areas during voluntary movements"J Neurosci. 21. 9377-9386 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Bai O, et al.: "Markov Process Amplitude EEG Model for Spontaneous Background Activity"J Clin Neurophysiol. 18. 283-290 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Nakamura M, et al.: "Automatic EEG interpretation adaptable to individual electroencephalographer using aritificial neural network"Int J A dapt Control Signal Process. 16. 25-37 (2002)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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