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Non invasive neuropathological evaluation of neuropathy using MR microscopy

Research Project

Project/Area Number 13670642
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurology
Research InstitutionOsaka University

Principal Investigator

ABE Kazuo  Osaka University Graduate School of Medicine, Lecturer, 医学系研究科, 講師 (60273687)

Co-Investigator(Kenkyū-buntansha) FUJIMURA Harutoshi  Osaka University Graduate School of Medicine, Associate Professor, 医学系研究科, 助教授 (20263246)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 2002: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2001: ¥2,100,000 (Direct Cost: ¥2,100,000)
KeywordsMR microscopy / Functional MRI (fMRI) / Iron / Microcirculation / functional MRI(fMRI) / function MRI / neuropathy
Research Abstract

For treatment of neurological diseases including neuropathy, neuropathological examination of biopsied specimen is essential. However, biopsy is invasive in nature, and another noninvasive methods may be needed. MR microscopy is a possible such a candidature method. In this study, we tried to differentiate nerves in 10 μm accuracy.
We, first, compared MRI images and of biopsied specimen and found good correlation between them. Trying microscopical MR images, we failed to get good images due to low signal noise ratio from iron deposits and microcirculation. Thus, we applied method based on functional MRI to identified concerning structures and identified lateral geniculate body that can hardly be detected in ordinal MRI techniques. In addition, we developed a method to detect iron deposits in nervous system.
In this point, we have not succeeded in MR microscopy, but in nearly feature we can get microscopical MR images of nerve in vivo. We believe that our study from 2001 to 2002 may be useful for future study.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] Fujita N, Tanaka H, Takanashi M, Hirabuki N, Abe K, Yoshimura H, Nakaimura H.: "Lateral geniculate nucleus : Anatomical and functional identification by use a MR imaging"American Journal of Neuroradiology. 22・10. 1719-1726 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hikita T, Abe K.: "Magnetic resonance imaging of peripheral nerve -Evaluation in patients wit HMSN(Hereditary motor and sensory neuropathy) and AIDP(acute inflammatory demyelinating polyneuropathy)-"Neuroradiology. 44・12. 537 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hattori N, Abe K, Sakoda S, Sawada T.: "Proton MR spectroscopic study at 3 Tesla on glutamate/glutaine in Alzheimer's disease"NeuroReport. 13・1. 183-186 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takanashi M, Abe K, Yanagihara T, Sakoda S, Tanaka H, Hirabuki N, Nakamura H, Norihiko Fujita N.: "A fMRI study of somatotopic representations of somatosensory stimulation in the cerebellum"Neuroradiology. 45・3. 170-176 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hikita T and Abe K: "Magnetic resonance imaging of peripheral nerve -Evaluation in patients with HMSN(Hereditary motor and sensory neuropathy) and AIDP(acute inflammatory demyelinating poly neuropatlry)"Neuroradiology. 44-12. 537 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hattori N, Abe K, Sakoda S, Sawada T: "Proton MR spectroscopic study at 3 Tesla on glutamate/glutaine in Alzheimer's disease"Neuro Report. 13-1. 183-186 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Fujita N, Tanaka H, Takanashi M, Hirabuki N, Abe K, Yoshimura H: "Lateral geniculate nucleus: Anatomical and functional identification by use a MR imaging"American Journal of Neuroradiology. 22-10. 1719-1726 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takanashi M, Abe K, Yanagihara T, Sakoda S, Tanaka H, Hirabuki N, Fujita N: "A fMRI study of somatotopic representations of somatosensory stimulation in the cerebellum"Neuroradiology. 44-3. 170-176 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Fujita N, Tanaka H, Takanashi M, Hirabuki N, Abe K, Yoshimura H, Nakamura H.: "Lateral geniculate nucleus : Anatomical and functional identification by use a MR imaging"American Journal of Neuroradiology. 22・10. 1719-1726 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hikita T, Abe K.: "Magnetic resonance imaging of peripheral nerve -Evaluation in patients with HMSN(Hereditary motor and sensory neuropathy) and AIDP(acute inflammatory demyelinating polyneuropathy)-"Neuroradiology. 44・12. 537 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hattori N, Abe K, Sakoda S, Sawada T.: "Proton MR spectroscopic study at 3 Tesla on glutamate/glutaine in Alzheimer's disease"Neuro Report. 13・1. 183-186 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] TAKANASHI M, Abe K, Yanagihara T, Sakoda S, Tanaka H, Hirabuki N, Nakamura H, Norihiko Fujita N.: "A fMRI study of somatotopic representations of somatosensory stimulation in the cerebellum"Neuroradiology. 45・3. 170-176 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Fujita N, Tanaka H, Takanashi M, Hirabuki N, Abe K, Yoshimura H, Nakamura H: "Lateral geniculate nucleus : Anatomical and functional identification by use a MR imaging"AJNR. 22. 1719-1726 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Hikita T, Abe K: "Magnetic resonance imaging of peripheral nerve-Evaluation in patients with HMSN(Hereditary motor and sensory neuropathy)and AIDP(acute inflammatory demyelinating polyneuropathy)-"Neuroradiology. (in press). (2002)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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