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Experimental and Clinical Study on Desynchronization of Biological Rhythms in Heart Failure

Research Project

Project/Area Number 13670697
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionToyama Medical and Pharmaceutical University

Principal Investigator

ASANOI Hidetsugu  Toyama Medical & Pharmaceutical University, Faculty of Medicine, Associate Professor, 医学部, 助教授 (00150128)

Co-Investigator(Kenkyū-buntansha) TAKASHIMA Shutaro  Toyama Medical & Pharmaceutical University, Health Administration Center, Assistant Professor, 保健管理センター, 講師 (50146586)
Project Period (FY) 2001 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2003: ¥100,000 (Direct Cost: ¥100,000)
Fiscal Year 2002: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2001: ¥3,100,000 (Direct Cost: ¥3,100,000)
KeywordsHeart Failure / Biological Rhythm / Sympathetic Nerve Activity / Ultradian Rhythm / Circadian Rhythm / Respiratory Training / Carbon Dioxide Chemosensitivity / Lung Stretch Reflex / テレメトリ / 精神ストレス / コヒーレンス解析 / 伝達関数 / β受容体機能 / 慢性心不全 / 同調・脱同調 / 睡眠脳波 / 視床下部
Research Abstract

Purpose :
To elucidate the desynchronization of internal biological rhythms in heart failure, we predicted the optimal cardiac and respiratory rhythms for 1)contractility modulation and 2)sympathetic modulation, and examined ultradian dynamics of physical activity, hemodynamics, and autonomic function in 3)patients with heart failure and 4)free-moving conscious rats with heart failure.
Methods & Results :
1)Slowing heart rate seems to be beneficial for synchronization of cardiac rhythm with slow Ca2+ cycling in the failing heart. Using system identification technique, we developed a mathematical model of force-frequency response and mechanical restitution in human failing hearts and predicted the optimal heart rate for both Ca2+ cycling and cardiac pumping ability.
2)Using system identification technique, we developed a model of respiratory modulation of sympathetic nerve activity and examined the optimal respiratory rhythm for effective sympathetic suppression in patients with heart failu … More re. The model predicted that a reduction of respiratory rhythm by half with doubling tidal volume suppressed sympathetic nerve activity three times greater than control, suggesting that a slowing respiration rhythm could effectively stabilize sympathetic tone in patients with heart failure.
3)Power spectral analysis for all-day heart rate and physical activity revealed that a prominent ultradian rhythm existed in both heart rate and physical activity in patients with heart failure. A more prominent ultradian rhythm of circadian changes in heart rate and physical activity was found in 50% of the subjects with mild hart failure. Their ultradian power normalized by the total power averaged 36.3±5.4% in heart rate and 38.9±11.5% in physical activity. However, the incidence and magnitude of the ultradian power of physical activity declined as the heart failure progressed.
4)Synchronization of ultradian rhythms of all-day physical activity, heart rate and blood pressure, autonomic function was examined in free-moving conscious rats with heart failure. A beautiful ultradian rhythm of activity was found in synchrony with hemodynamics and autonomic function but markedly attenuated in amplitude in the rat with heart failure.
Conclusions :
All these studies suggest that desynchronization of biological rhythms(activity, hemodynamics, and autonimic function) is a characteristic feature of heart failure and that slowing the biological rhythms could be effective for their resynchronization processes. Less

Report

(4 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (33 results)

All Other

All Publications (33 results)

  • [Publications] Yamada K, Asanoi H, et al.: "Parametric system identification of arterial baroreflex with random perturbation of blood pressure in normal subjects."J Cardiovasc Pharmaciol. 42(Suppl). S11-S13 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Igawa A, Nozawa T, et al.: "Long-term treatment with low-dose, but not high-dose, guanethidine improves ventricular function and survival of rats with heart failure after myocardial infarction"J Am Coll Cardiol. 42. 541-548 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yamazaki T, Asanoi H, et al.: "Circadian dynamics of heart rate and physical activity in patients with heart failure"Clin Exp Hypertension. (in press). (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ueno H, Asanoi H, et al.: "Attenuated respiratory modulation of chemoreflex-mediated sympathoexcitation in patients with chronic heart failure"J Card Fail. (in press). (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 麻野井英次: "筋交感神経活動を用いた慢性心不全の病態解析"循環制御. 24. 202-206 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 麻野井英次: "慢性心不全患者の睡眠時無呼吸に対する夜間酸素療法"呼吸と循環. 52. 73-78 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 麻野井英次: "循環器New Trendsシリーズ、心不全治療への挑戦"堀 正二編集, Medical View社, 東京. 209 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yamada K, Asanoi H, et al.: "Parametric system identification of arterial baroreflex with random perturbation of blood pressure in normal subjects"J Cardiovasc Pharmaciol. 42(suppl). S11-S13 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Igawa A, Nozawa T, et al.: "Long-term treatment with low-dose, but not high-dose, guanethidine improves ventricular function and survival of rats with heart failure after myocardial infarction"J Am Coll Cardiol. 42. 541-548 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yamazaki T, Asanoi H, et al.: "Circadian dynamics of heart rate and physical activity in patients with heart failure"Clin Exp Hypertension. (in press). (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ueno H, Asanoi H, et al.: "Attenuated respiratory modulation of chemoreflex-mediated sympathoexcitation in patients with chronic heart failure"J Card Fail. (in press). (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Asanoi H: "Pathophysiologic analysis of chronic heart failure using muscle sympathetic nerve activity(in Japanese)"Circulatory regulation. 24. 202-206 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Asanoi H: "Home oxygen therapy for sleep apnea syndrome in patients with chronic heart failure(in Japanese)"Kokyu & Junkan. 52. 73-78 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Asanoi H: "Circulation New Trend, Challenge to Heart Failure Treatment(in Japanes)"Medical View, Tokyo. (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yamada K, Asanoi H, et al.: "Parametric system identification of arterial baroreflex with random perturbation of blood pressure in normal subjects"J Cardiovasc Pharmaciol. 42(suppl). S11-S13 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ueno H, Asanoi H, et al.: "Attenuated respiratory modulation of chemoreflex-mediated sympathoexcitation in patients with chronic head failure"J Card Fail. (In press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Igawa A, Nozawa T, et al.: "Long-term treatment with low-dose, but not high-dose, guanethidine improves ventricular function and survival of rats with heart failure after myocardial infarction"J Am Coll Cardiol. 42. 541-548 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 麻野井英次: "筋交感神経活動を用いた慢性心不全の病態解析"循環制御. 24. 202-206 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 麻野井英次: "慢性心不全患者の睡眠時無呼吸に対する夜間酸素療法"呼吸と循環. 52. 73-78 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] 山田邦博, 麻野井英次 他: "慢性心不全患者の運動時換気指標による中枢性炭酸ガス感受性の推定"心臓. 35(特別号2). 52-54 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 麻野井英次: "循環器New Trendsシリーズ、心不全治療への挑戦"堀 正二編集, Medical View社, 東京,. 209 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Joho S, Asanoi_H, Takagawa J, Kameyama T, Hirai T, Nozawa T, Umeno K, Shimizu M, Seto H, Inoue H: "Cardiac sympathetic denervation modulates the sympathoexcitatory response to acute myocardial ischemia"J Am Coll Cardiol. 39. 436-442 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Joho S, Asanoi H, Ishizaka S, Kameyama T, Inoue H: "Disparate force-frequency effects of pimobendan and dobutamine in conscious dogs with tachycardia-induced cardiomyopathy"J Card Fail. 8. 423-430 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Joho S, Asanoi H, Sakabe M, Nakagawa K, Kameyama T, Hirai T, Nozawa T, Kotoh K, Misaki T. Jinbo M. Inoue H.: "Long-term usefulness of percutaneous intrapericardial fibrin-glue fixation therapy for oozing type of left ventricular free wall rupture : a case report"Circ J. 66. 505-706 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 麻野井英次: "ピモベンダンの作用機序-交感神経活動への影響"医薬ジャーナル. 38. 129-133 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 麻野井英次: "経口強心薬(PD阻害薬)"総合臨床. 5. 768-771 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 1.和泉徹, 麻野井英次, 小玉誠 編: "入退院を繰り返す慢性心不全の臨床"医学書院. 209 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Goso Y, Asanoi H, Ishise H, Kameyama T, Hirai T, Nozawa T, Takashima S, Umeno K, Inoue H: "Respiratory modulation of muscle sympathetic nerve activity in patients with chronic heart failure"Circulation. 104. 418-423 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Nozawa T, Asanoi H, Inoue H, TOWARD Investigators: "Occurrence of ischemic stroke in patients with non-rheumatic atrial fibrillation"Jpn Circ J. 65. 404-408 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Nozawa T, Igawa A, Fujii N, Kato B. Yoshida N, Asanoi H, Inoue H: "Effects of long-term renal sympathetic denervation on heart failure after myocardial infarction in rats"Heart Vessels. 16. 51-56 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Joho S, Asanoi H, Takagawa J, Kameyama T, Hirai T, Nozawa T, Umeno K, Shimizu M, Seto H, Inoue H: "Cardiac sympathetic denervation modulates the sympathoexcitatory responses to acute myocardial ischemia"J Am Coll Cardiol. 39. 436-442 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] 麻野井英次: "睡眠時無呼吸と心不全"medicina. 38. 1702-1703 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kosugi Y, Asanoi H, Maeda S, Inoue H: "Physical Fitness and Health Promotion in Active Aging"Backhuys Publishers. 225 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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