| Project/Area Number |
13670739
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
|
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| Research Institution | Osaka City University |
|---|
Principal Investigator |
YASUNARI Kenichi Osaka City University, Assistant Professor, 大学院・医学研究科, 講師 (90231646)
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| Project Period (FY) |
2001 – 2003
|
| Project Status |
Completed (Fiscal Year 2003)
|
| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2003: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2002: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2001: ¥1,500,000 (Direct Cost: ¥1,500,000)
|
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| Keywords | hypertension / neutrophils / oxidative stress / monocytes / risk factors / coronary artery / 血圧 / 白血球 / 高血圧自然発症ラット / ホストリパーゼD / Cキナーゼ / 血管平滑筋細胞 / アンジオテンシンII / 高血糖 / 動脈硬化 |
|---|
| Research Abstract |
We have demonstrated that pressure itself increased oxidative stress of human coronary smooth muscle cells (1,3). In experimental animals, we have shown the increased oxidative stress of neutrophils (5). In patients with essential hypertension, we have shown the increased oxidative stress both in neutrophils and monocytes (2) which are modified by antihypertensive drugs such as carvedilolor valsartan (7,8).
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