| Project/Area Number |
13670750
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Niigata university of Pharmacy and Applied Life Sciences |
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Principal Investigator |
WATANABE Kenichi Niigata University of Pharmacy and Applied We Sciences, Department of Clinical Pharmacology, Professor, 薬学部・臨床薬理学, 教授 (70175090)
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| Co-Investigator(Kenkyū-buntansha) |
MA Meilei Niigata University of Pharmacy and Applied Life Sciences, Department of Clinical Pharmacology, Lecturer, 薬学部・臨床薬理学, 助手 (20333536)
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| Project Period (FY) |
2001 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥4,100,000 (Direct Cost: ¥4,100,000)
Fiscal Year 2002: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 2001: ¥2,300,000 (Direct Cost: ¥2,300,000)
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| Keywords | Heart failure / Angiotensin converting enzyme inhibitor / β-blocker / Myocardial sympathetic denervation / Immuno-deficiency / Angiotensin-II receptor blockade / Ischemic heart disease / Fatty acid metabolism / 心筋炎 / 遺伝子導入 / 拡張型心筋症 / CD36欠損症 |
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| Research Abstract |
Dilated cardiomyopathy is a set of heterogeneous diseases of left ventricular dysfunction of unknown etiology, which has a variety of clinical courses and pathological findings. Long-chain fatty acids are one of the major cardiac energy substrates, so, understanding long-chain fatty acid metabolism may help in elucidating the mechanisms of various heart diseases. Angiotensin(AT)-II receptor blockers (ARB) and angiotensin-converting enzyme inhibitors (ACEI) have been shown to reduce morbidity and mortality in patients with heart failure, but their inhibitory actions on AT-I-induced increases in blood pressure in heart failure are not clear. AT-I blocking and cardioprotective properties of the ARB candesartan and ACEI quinapril were studied in a rat model of dilated cardiomyopathy. Metaiodobenzylguanidine(MIBG) is a reliable marker for the detection of cardiac adrenergic neuronal damage in heart failure. The cardioprotective properties of carvedilol, a vasodilating β-adrenoceptor blocking agent, were studied in a rat model of dilated cardiomyopathy. Myocardial long-chain fatty acids metabolism was decreased in rats with heart failure. Although low-dose candesartan can block increases in blood pressure with circulating AT-I same to the extent as high-dose quinapril, it does not confer sufficient protection against injury from the rennin-angiotensin system in heart failure. Carvedilol has beneficial effects and protects cardiac adrenergic neurons in dilated cardiomyopathy.
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