Study of inhibitory effects of HMG Co A reductase inhibitor on in-vivo thrombus formation

• Project/Area Number: 13670768
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: KURUME UNIVERSITY
• Principal Investigator: KATOH Atsushi Kurume University, Department of internal medicine III, assistant professor, 医学部, 助手 (70279165)
• Co-Investigator(Kenkyū-buntansha): MUROHARA Toyoaki Kurume University, Cardiovascular Research Institute, associate professor, 循環器病研究所, 講師 (90299503) ; IKEDA Hisao Kurume University, Department of internal medicine III, associate professor, 医学部, 助教授 (50168134)
• Project Period (FY): 2001 – 2002
• Project Status: Completed (Fiscal Year 2002)
• Budget Amount: ¥3,600,000 (Direct Cost: ¥3,600,000); Fiscal Year 2002: ¥1,800,000 (Direct Cost: ¥1,800,000); Fiscal Year 2001: ¥1,800,000 (Direct Cost: ¥1,800,000)
• Keywords: Thrombus / Platelet / HMG Co A reductase inhibitor / HMGCo還元酵素阻害剤 / HMG Co A 還元酵素阻害薬

Research Abstract

To investigate whether HMG Co A reductase inhibitor inhibits in-vivo thrombus formation, we studied the effects of cerivastatin on rat carotid artery thrombus model, rat platelet activation and rat coagulation-fibrinolysis system. Cerivastatin significantly inhibited in-vivo thrombus formation. Crivastatin also significantly decreased platelet aggregation and platelet surface expression of P-selectin induced ADP, suggesting that cerivastatin inhibits platelet activation. Cerivastatin didn't affect rat plasma levels of fibrinogen, tissue factor, tissue palsminogen activating factor and tissue plasminogen activator inhibitory factor, suggesting that cerivastatin didn't affect rat coagulation-fibrinolysis system. Thus, HMG Co A reductase inhibitor may inhibit in-vivo thrombus formation by decreasing platelet activation.

Research Products

• [Publications] Shintani S: "Mobilization of endothelial progenitor cells in patients with acute myocardial infarction"Circulation. 103. 2776-2779 (2001)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Haramaki N: "Long-term smoking causes nitroglycerin resistance in platelets by depletion of intraplatelet glutathione"Arterioscler Thromb Vasc Biol.. 21. 1852-1856 (2001)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Katoh A: "Coexistence of impairment of endothelium-derived nitric oxide a nd platelet-derived nitric oxide in patients with coronary risk factors"Circ J.. 66. 837-740 (2002)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Murohara T: "Vitamin E inhibits lysophosphatidylcholine-induced endothelial dysfunction and platelet activation"Antioxid Redox Signal. 4. 791-798 (2002)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Shintani S, Murohara T, Ikeda H, Ueno T, Honma T, Katoh A, Sasaki K, Shimada T, Oike Y, Imaizumi T: "Mobilization of endothelial progenitor cells in patients with acute myocardial infarction"Circulation. 103. 2776-2779 (2001)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Haramaki N, Ikeda H, Takajo Y, Katoh A, Kanaya S, Shintani S, Haramaki R, Murohara T, Imaizumi T: "Long-term smoking causes nitroglycerin resistance in platelets by depletion of intraplatelet glutathione"Arterioscler Thromb Vasc Biol.. 21. 1852-1856 (2001)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Katoh A, Ikeda H, Takajo Y, Haramaki N, Murohara T, Shintani S, Kanaya S, Yokoyama S, Ueno T, Honma T, Imaizumi T: "Coexistence of impairment of endothelium-derived nitric oxide and platelet-derived nitric oxide in patients with coronary risk factors"Circ J. 66. 837-840 (2002)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Murohara T, Ikeda H, Katoh A, Takajo Y, Otsuka Y, Haramaki N, Imaizumi T: "Vitamin E inhibits lysophosphatildylcholine-induced endothelial dysfunction and platelet activation"Antioxid Redox Signal. 4. 791-798 (2002)
  • Description: 「研究成果報告書概要(欧文)」より