| Project/Area Number |
13670768
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | KURUME UNIVERSITY |
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Principal Investigator |
KATOH Atsushi Kurume University, Department of internal medicine III, assistant professor, 医学部, 助手 (70279165)
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| Co-Investigator(Kenkyū-buntansha) |
MUROHARA Toyoaki Kurume University, Cardiovascular Research Institute, associate professor, 循環器病研究所, 講師 (90299503)
IKEDA Hisao Kurume University, Department of internal medicine III, associate professor, 医学部, 助教授 (50168134)
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| Project Period (FY) |
2001 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2002: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 2001: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | Thrombus / Platelet / HMG Co A reductase inhibitor / HMGCo還元酵素阻害剤 / HMG Co A 還元酵素阻害薬 |
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| Research Abstract |
To investigate whether HMG Co A reductase inhibitor inhibits in-vivo thrombus formation, we studied the effects of cerivastatin on rat carotid artery thrombus model, rat platelet activation and rat coagulation-fibrinolysis system. Cerivastatin significantly inhibited in-vivo thrombus formation. Crivastatin also significantly decreased platelet aggregation and platelet surface expression of P-selectin induced ADP, suggesting that cerivastatin inhibits platelet activation. Cerivastatin didn't affect rat plasma levels of fibrinogen, tissue factor, tissue palsminogen activating factor and tissue plasminogen activator inhibitory factor, suggesting that cerivastatin didn't affect rat coagulation-fibrinolysis system. Thus, HMG Co A reductase inhibitor may inhibit in-vivo thrombus formation by decreasing platelet activation.
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