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Investigation of flow-mediated vasodilation in female athletes with exercise-associated amenorrhea

Research Project

Project/Area Number 13670771
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionKurume University

Principal Investigator

YOSHIDA Noriko  Kurume University, Institute of health and sports sciences, Associated Professor, 健康・スポーツ科学センター, 助教授 (10210709)

Co-Investigator(Kenkyū-buntansha) MITSUZONO Ryouichi  Kurume University, Institute of health and sports sciences, Professor, 健康・スポーツ科学センター, 教授 (20200058)
TOYOMASU Koji  Kurume University, Institute of health and sports sciences, Professor, 健康・スポーツ科学センター, 教授 (50172218)
IKEDA Hisao  Kurume University, Department of Internal Medicine III, Associated Professor, 医学部, 助教授 (50168134)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥4,100,000 (Direct Cost: ¥4,100,000)
Fiscal Year 2002: ¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 2001: ¥2,000,000 (Direct Cost: ¥2,000,000)
Keywordsendothelium / exercise / amenorrhea / estradiol / 血管内皮機能 / 運動性無月経 / エストラヂオール
Research Abstract

Background Exercise-associated amenorrhea (EAA) is frequently observed in highly trained female athletes associated with a hypoestrogenic state. Vascular endothelial function is modulated during the menstrual cycle. The purpose of the present study was to investigate vascular endothelial function in highly trained female athletes with EAA.
Methods and Results The study subjects consisted of 26 female volleyball players, who had a regular menstrual cycle (regular group, n=15) and EAA (EAA group, n=11). Vasodilatory responses of the brachial artery were evaluated by measuring endothelium-dependent flow-mediated vasodilation (FMD) and glyceryltrinitrate (an endothelium-independent dilator)-induced vasodilation using high-resolution ultrasonography. Plasma levels of estradiol and progesterone were measured in all the subjects. In the regular group, all measurements were performed at 12 to 14 days after the first day of the last menstrual cycle. Plasma estradiol levels were significantly lower in the EAA group than in the regular group (p<0.05). Plasma progesterone levels did not differ between the two groups. The regular and EAA groups did not differ in terms of arterial diameter and blood flow at baseline, nor in blood flow during hyperemia. FMD was significantly smaller in the EAA group than in the regular group (p<0.05). Glyceryltrinitrate-induced vasodilation did not differ between the groups. FMD significantly correlated with plasma estradiol levels (r=0.41, p<0.05).
Conclusions Endothelium-dependent vasodilation was impaired in highly trained female volleyball players with EAA associated with a hypoestrogenic state. Thus, the detrimental effects of vigorous exercise training on vascular endothelial function may have important clinical implications for the health of female athletes.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] 吉田 典子: "運動負荷試験:最近の話題"Annual Review循環器2001. 中外医学社. 155-160 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 吉田 典子: "運動指導"臨床高血圧 朝倉書店. 139-146 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 池田 久雄: "喫煙と血小板"血小板生物学,メディカルレビュー社. (印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Noriko Yoshida: "Topics of Exercise Stress Test, Annual Review in cardiology 2001"Tyuugai Igakusya. 155-160 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Noriko Yoshida: "Exercise Therapy of Hypertension, Rinsyou Kouketuatu"Asakura Syoten. 139-146 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hisao Ikeda: "Smoking and Platelet, Biology of Platelet"Medical Review, (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary

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Published: 2001-04-01   Modified: 2016-04-21  

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