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Analysis of cardiac lymphatic dynamics in beating canine hearts using a high-speed CCD microscope

Research Project

Project/Area Number 13670773
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionKawasaki Medical College of Allied Health Professions

Principal Investigator

HIRAMATSU Osamu  Kawasaki Medical College of Allied Health Professions, Medical Engineering, Assistant Professor, 臨床工学科, 講師 (50208849)

Co-Investigator(Kenkyū-buntansha) MOCHIZUKI Seiichi  Kawasaki Medical College of Allied Health Professions, Medical Engineering, Associate Professor, 臨床工学科, 助教授 (60259596)
MATSUMOTO Takeshi  Kawasaki Medical College of Allied Health Professions, Medical Engineering, Associate Professor, 臨床工学科, 助教授 (30249560)
GOTO Masami  Kawasaki Medical College of Allied Health Professions, Medical Engineering, Professor, 臨床工学科, 教授 (50148699)
KAJIYA Fumihiko  Okayama University, Graduate School of Medicine and Dentistry, Cardiovascular Physiology, Professor, 大学院・医歯学総合研究科, 教授 (70029114)
TACHIBANA Hiroyuki  Kawasaki Medical College of Allied Health Professions, Medical Engineering, Assistant, 臨床工学科, 助手 (00241216)
OGASAWARA Yasuo  Kawasaki Medical School, Medical Engineering, Associate Professor (10152365)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2002: ¥800,000 (Direct Cost: ¥800,000)
KeywordsCardiac lymphatics / CCD microscope / Flow visualization / Caediac lymphtic / 心臓リンパ管 / high speed CCD生体顕微鏡 / リンパ流速
Research Abstract

Control of the interstitial fluid in the myocardium is very important, since interstitial edema has been demonstrated to impair cardiac function. To evaluate the cardiac lymphatic dynamics, we measured phasic diameter changes and flow velocity waveform of the epicardial lymphatics during a cardiac cycle. In 10 anesthetized open-chest dogs, India ink and suspension fluid (Levovist) were injected through a 27-gauge needle into the myocardium of the left ventricular apex for visualization of the lymphatic network and flow velocity, respectively. The cardiac lymphatics were visualized by India ink using a needle-lens CCD microscope at end-diastole and end-systole under control conditions. Velocities of Levovist flowing in the epicardial lymphatics were calculated by frame-to-frame analysis using a high-speed CCD microscope based on the moving distance of Levovist suspension per 5 ms. The lymph vessels with valves were clearly visualized in all cases. The diameters of epicardial lymphatics showed an increasing trend from 179 ± 47 μm at end-diastole to 185 ± 44 μm at end-systole without statistical significance. The cardiac lymph flow velocity was accelerated in early systolic phase. The mid-systolic dip was followed by late systolic and then early diastolic forward flow. A reverse flow was observed in some cases during late diastolic phase. In conclusion, because of small phasic diameter changes during a cardiac cycle, drainage of cardiac lymph is not controlled on a beat-to-beat basis. Cardiac lymphatic flow was slow but exhibited a unique phasic pattern during a cardiac cycle. Flow-velocity pattern indicated that major determinants of cardiac lymph dynamics during systole may be myocardial strain and intramyocardial pressure due to myocardial contraction.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] Fumiyuki Shigeto: "Analysis of cardiac lymphatic dynamics with levovist in beating canine hearts using a high-speed CCD microscope"Microcirculation Annual 2001. 17. 133-134 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 重藤史行: "High speed CCD生体顕微鏡を用いた心外膜側リンパ特性のイメージ解析"電子情報通信学会技術研究報告. 101. 45-50 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 重藤史行: "CCD生体顕微鏡を用いた心外膜微小リンパ管の拍動変化および流動特性に関する解析"日本バイオレオロジー学会誌(B&R). 16. 108-119 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Eiji Toyota: "Dinamic changes in three-dimensional architecture and vascular volume of transmural coronary microvasculature between diastolic-and systolic-arrested rat hearts"Circulation. 105. 621-626 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takahiko Kiyooka: "Direct in vivo visualization of rat coronary capillary hemodynamics by intravital pencil lens-probe CCD videomicroscopy"Microcirculation annual 2002. 18. 121-122 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Osamu Hiramatsu: "Visualization of coronary microcirculation"Microcirculation annual 2002. 18. 11-12 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Fumiyuki Shigeto: "Analysis of cardiac lymphatic dynamics with levovist in beating canine hearts using a high-speed CCD microscope"Microcirculation Annual 2001. 17. 133-134 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Eiji Toyota: "Dynamic changes in three-dimensional architecture and vascular volume of transmural coronary microvasculature between diastolic-and systolic-arrested rat hearts"Circulation. 105. 621-626 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takahiko Kiyooka: "Direct in vivo visualization of rat coronary capillary hemodynamics by intravital pencil lens-probe CCD videomicroscopy"Microcirculation annual 2002. 18. 121-122 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Osamu Hiramatsu: "Visualization of coronary microcirculation"Microcirculation annual 2002. 18. 11-12 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Eiji Toyota: "Dynamic changes in three-dimensional architecture and vascular volume of transmural coronary microvasculature between diastolic-and systolic-arrested rat hearts"Circulation. 105. 621-626 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Takahiko Kiyooka: "Direct in vivo visualization of rat coronary capillary hemodynamics by intravital pencil lens-probe CCD videomicroscopy"Microcirculation annual 2002. 18. 121-122 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Osamu Hiramatsu: "Visualization of coronary microcirculation"Microcirculation annual 2002. 18. 11-12 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 重藤史行, 平松修他: "High speed CCD生体顕微鏡を用いた心外膜側リンパ流動特性のイメージ解析"信学技報. 101. 45-50 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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