| Project/Area Number |
13670793
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Nagoya University |
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Principal Investigator |
KIMURA Hiroshi Nagoya University, University Hospital, Assistant Professor, 医学部附属病院, 講師 (30303621)
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| Co-Investigator(Kenkyū-buntansha) |
MORISHIMA Tsuneo Nagoya University, University School of Medicine, Professor, 医学部, 教授 (90157892)
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| Project Period (FY) |
2001 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,600,000)
Fiscal Year 2002: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2001: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | Immunocompromised host / viral infection / viral load / real-time PCR / tetramer / cellular immunity |
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| Research Abstract |
Recent advances in transplantation medicine result in an increase of immunocompromised hosts. The importance of herpes viruses, which reactivate in immunodeficiency, is increasing.
To clarify the mechanism on reactivation of these viruses and to establish prophylaxis and treatment, we established quantifying viral load and viral specific cellular immunity against herpesviruses. Using these systems, we found the following findings.
1. Quantitation of Epstein-Barr viral load using real-time PCR was useful for the diagnosis of lymphoproliferative disorders in patients with hematopoietic stem cell transplantation. Furthermore, quantifying viral specific T lymphocytes was useful for determing the treatment.
2. Viral type was related with the prognosis and relapse of neonatal herpes simplex virus infections.
3. Transmission of cytomegalovirus via breast milk was important among premature infants, but symptomatic infections were rare in the population.
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