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Anti-tumor effect by non-steroidal anti-inflammatory drugs

Research Project

Project/Area Number 13670800
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

ADACHI Souichi  Kyoto University, Graduate school of medicine, Instructor, 医学研究科, 助手 (10273450)

Co-Investigator(Kenkyū-buntansha) LIN Ying-wei  Kyoto University, Graduate school of medicine, Instructor, 医学研究科, 助手 (40283600)
NAKAHATA Tatsutoshi  Kyoto University, Graduate school of medicine, Professor, 医学研究科, 教授 (20110744)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2002: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2001: ¥1,500,000 (Direct Cost: ¥1,500,000)
KeywordsNSAID / Apoptosis / Mitochondria / Anti-tumor effect / CLL / Neuroblastoma / CLL / カスパーゼ / 慢性リンパ性白血病
Research Abstract

We have been reported that etodolac, a chiral non-steroidal anti-inflammatory drug (NSAID) was shown to be pro-apoptotic in primary CLL cells both in vitro and in vivo. Here we also show anti-tumor effect of both the R and S-enatiomers of etodolac against several cancers including neuroblastoma cell line and primary CML cells. Etodolac has additive cytotoxic effects from combinations with other chemotherapeutic drugs such as cyclophosphamide and vincristine. The mechanism of cell death is mitochondrial-dependent pathway because we show that (1) dysfunction of mitochondrial oxygen uptake and membrane potential (2) activation of caspase 9 and caspase 3 (3) degradation of Mcl-1

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (5 results)

All Other

All Publications (5 results)

  • [Publications] Souichi Adachi: "Apoptosis induced by molecular targeting therapy in hematological malignancies"Acta Haematologica. 111. 107-123 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 足立 壮一: "血液疾患とアポトーシス"小児内科. 34. 1803-807 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] souichi Adachi: "Apoptosis induced by molecular targeting therapy in hematological malignancies"Acta Haematologica. 111. 107-123 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] souichi Adachi: "Apoptosis in hematological malignancy"Japanese Journal of Pediatric Medicine. 34. 1803-1807 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 足立 壮一: "血液疾患とアポトーシス"小児内科. 34巻12号. 1803-1807 (2002)

    • Related Report
      2002 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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