• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Promoter analysis of IL-4R gene and its possible associateion of atopic dermatitis

Research Project

Project/Area Number 13670897
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Dermatology
Research InstitutionOsaka City University

Principal Investigator

FUKAI Kazuyoshi  OSAKA CITY UNIVERSITY Graduate School of Medicine, DERMATOLOGY, ASSOCIATE PROFESSOR, 大学院・医学研究科, 助教授 (20244642)

Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2002: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2001: ¥2,000,000 (Direct Cost: ¥2,000,000)
KeywordsATOPIC DERMATITIS / PSORIASIS / POLYMORPHISM / TRANSCRIPTION FACTOR / PROMOTER / インターロイキン4レセプター / SNP / サイトカイン / 遺伝子発見の調節
Research Abstract

The gene encoding the interleukin-4 receptor alpha chain (IL4R) has received attention as a candidate gene for atopic diseases, and associations have been reported between functionally significant coding polymorphisms of the gene and atopic diseases (Khurana et al. 1997; Mitsuyasu et al. 1998; Oiso et al 2000). Recently, Ober et al. (2000) suggested that the variations outside the coding region of the IL4R gene influence the susceptibility for atopy and asthma. Therefore, we investigated the 5'-flanking region of the gene and identified four new polymorphisms in the IL4R transcriptional promoter: -327A/C, -326C/A, -186A/G, -184A/G. We carried out association study of these polymorphisms in patients with 111 cases of atopic dermatitis versus 82 normal controls. We also recruited 73 patients with psoriasis vulgaris as the second control group. We further investigated more upstream of the 5'-flanking region of the gene and identified two new polymorphisms: -1914T/C and -3223C/T. Frequency of these polymorphisms were examined in 118 patients with atopic dermatitis, 89 normal controls and 70 patients with psoriasis. We found that these polymorphisms have association with atopic dermatitis. Unexpectedly, we also found that four polymorphisms; -327A/C, -326C/A, -186A/G, -184A/G have association with psoriasis as well.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] Richards KA et al.: "A novel mutation in KIT gene results in piebaldism with progresive depigmentation"J Am Acad Dermatol. 44. 288-291 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Akahosi K et al.: "Duplication of 15q11-q14, including the P gene, in a patient with generalized hyperpigmentation"Am J Med Genet. 104. 299-302 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Karim M et al.: "Apparent genotype-phenotype correlation 'childhood' 'adolescent' 'adult' Chediak-Higashi syndrome"Am J Med Genet. 108. 16-22 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] HIGASHI N. et al.: "Papular purpuric gloves and socks syndrome with bloody bullae"J Dermatol. 29. 371-375 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kato A et al.: "Association of SPINK5 gene polymorphisms with atopic dermatitis in the Japanese population"Br J Dermatol. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kato A et al.: "A novel P gene missense mutation in a Japanese patient with oculocutaneous albinism type II (OCA2)"

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 深井和吉: "現代医療 34巻8号"現代医療社. 214 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Richards KA, Fukai K, Oiso N, Paller AS: "A novel mutation in KIT gene results in piebaldism with progressive depigmentation"J Am Acad Dermatol. 44. 288-292 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Akahoshi K, Fukai K, Kato A, Kimiya S, Kubota T, Spritz: "Duplication of 15q11.2-ql4, including the P gene, in an patient with generalized hyperpigmentation"Am J Med Genet. 104. 299-302 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Karim M, Suzuki K, Fukai,K, Oh J, Nagle DL, Moore K, Barbosa E, Falik-Borenstein T, Filipovich A, Ishida Y, Kivrikko S, Klein C, Kreuz F, Levin A, Miyajima H, Russo C, Uyama E, Vierimaa O, Spritz R: "Apparent genotype-phenotype correlation in 'childhood', 'adolescent' and 'adult' Chediak-Higashi syndrome"Am J Med Genet. 108. 16-22 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Fridman C, Hosomi N, Yarela MC, Souza AH, Fukai F, Koiffman CP: "Angelman syndrome associated with OCA2 due to an intragenic deletion of the P gene"Am J Med Genet. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] N Higashi, K Fukai, D Tsuruta, J Nagao, H Ohira, M Ishii: "Papular purpuric gloves and socks syndrome with bloody bullae"J Dermatol. 29. 371-375 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] A. Kato, K. Fukai, N. Oiso, N. Hosomi, T. Murakami, M. Ishii: "Association of SPINK5 gene polymorphisms with atopic dermatitis in the Japanese population"Br J Dermatol. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Atsushi Kato, Kazuyoshi Fukai, Naoki Oiso, Naoko Hosomi, Shinji Saitoh, Takahito Wada, Hiroshi Shimizu, Masamitsu Ishii: "A novel P gene missense mutation in a Japanese patient with oculocutaneous albinism type II (OCA2)"J Dermatol Sci. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] N Oiso, MD, K Fukai, MD, N Hosomi, MD and M Ishii, MD: "Guttate morphoea with Christmas-tree distribution in a patient with human T-cell lymphoma/lymphotropic virus type-1 (HTLV-1) infection"Clin Exp Dermatol. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] N.Higashi, K.Fukai, et al.: "Papular-purpuric gloves-and-socks syndrome with bloody bullae"J Dermatology. 29. 371-375 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Rechards KA, K.Fukai, et al.: "A novel mutation in KIT results in piebaldism with progressive depigmentation"J Am Acad Dermatol. 44. 288-292 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Akahoshi K, K.Fukai, et al.: "Duplication of 15q11.2-q14, including the P gene, in a woman with generalized skin hyperpigmentation"Am J Med Genet. 104. 299-302 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Karim M, Suzuki K, Fukai K, et al.: "Apparent genotype-phenotype correlation in 'childhood', 'adolescent' and 'adult' Chediak-Higashi syndrome"Am J Med Genet. 108. 16-22 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] A Kato, K Fukai, et al.: "Association of SPINK5 gene polymorphisms with atopic dermatitis in the Japanese population"Br J Dermatol. (in press).

    • Related Report
      2002 Annual Research Report
  • [Publications] A Kato, K Fukai, et al.: "A novel P gene missense mutation in a Japanese"J Delmatol Sci. (in press).

    • Related Report
      2002 Annual Research Report
  • [Publications] Richards KA, Fukai K, OiseN, et al.: "A novel mutation in KIT gene results in piebaldism with Progressive clepigmentation"J Am Acad Permatol. 44. 288-292 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Akahoshi K, FUKAI K, et al.: "Duplication of 15q11.2-q14, including the P gene, in a woman with generalized skin hyperpigmentation"Am J Med Genet. 104. 299-302 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Karin M, Suzuki K, Fukai K et al.: "Apparent genotype-phenotype correlation in childhood, adolescent, and adult Chediak-Higashi syndrome"Am J Med Genuet. 108(1). 16-22 (2002)

    • Related Report
      2001 Annual Research Report

URL: 

Published: 2001-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi