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Artificial spacing of risk organs from radiation target by liquid injection into peritoneal cavity

Research Project

Project/Area Number 13670908
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionTohoku University

Principal Investigator

NEMOTO Kenji  Tohoku University, Graduate School of Medicine, Lecture, 大学院・医学系研究科, 講師 (10208291)

Co-Investigator(Kenkyū-buntansha) MIYACHI Hideo  Tohoku University, Hospital, Research Associate, 病院・助手 (70004728)
Project Period (FY) 2001 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 2003: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2002: ¥1,100,000 (Direct Cost: ¥1,100,000)
KeywordsAscitis / DVH / Radiation therapy / Fluid injection / SRT / スペーサー / 腹水 / 術中照射 / バルーン / 重要臓器 / 治療計画 / 定位照射 / カテーテル / 線量分布 / 内視鏡的手技
Research Abstract

Using 10 pair of CT scan data set, one with ascitis and another without ascitis, the influence of ascitis on dose volume histogram of radiation therapy. Sham targets were set in liver, para-aortic lymph nodes, iliac lymph nodes, uterus, and prostate (2-4cm in diameter) and radiotherapy planning was done for each target using four box-field method. The margin from CTV was 1cm in all cases. As a result, 40 pair of radiotherapy plan (liver, para-aortic lymph node, iliac lymph node, and uterus or prostate) was made for each sham target and DVH of these plans were compared and analyzed with radiotherapy computer. Risk organ was defined as intestine and abdominal wall or diaphragm for upper abdominal tumor. For pelvic tumor, risk organs was defined as rectum and urinary bladder.
In all patients, the existence and volume of ascitis did not significantly influence dose or intestine, rectum, urinary bladder. However, in case of liver surface tumor radiation therapy, ascitis significantly reduce the dose for diaphragm and abdominal wall. In case of radiation therapy of liver tumor that is adjacent to intestine (under part of liver surface), ascitis was also expected to reduce the intestinal radiation dose.
In conclusion, liquid, injection into peritoneal space before radiation therapy for surface liver tumor seems to reduce toxicity. However, daily CT checking and positioning of patients is essential. Subtable for patients fixation and special stretcher to transport patients from CT table to linac table is very useful for this pourpose.

Report

(4 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] Nemoto K et al.: "A novel support system for patient immobilization and transportation for daily computed tomographic localization of target prior to radiation therapy."Int J Radiat Oncol Biol Phys. 55. 1102-1108 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nemoto K et al.: "Radiation therapy combined with cis-diammine-glycolatoplatinum (nedaplatin) and 5-Fluorouracil for untreated and recurrent esophageal cancer"Am J Clin Oncol. 26. 46-49 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Wada H, Nemoto K, et al.: "Univariate analysis of factors correlated with tumor control probability of three-dimensional conformal hypofractionated high-dose radiotherapy for small pulmonary or hepatic tumors."Int J Radiat Oncol Biol Phys. 58. 1114-1120 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nomiya T, Nemoto K, et al.: "Relationships between radiosensitivity and microvascular density in esophageal carcinoma : significance of hypoxic fraction. 58:589-596,2004."Int J Radiat Oncol Biol Phys. 58. 589-596 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ogawa Y, Nemoto K, et al.: "Results of radiation therapy for uterine cervical cancer using high dose rate remote after loading system."Tohoku J Exp Med. 199. 229-238 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Wada H, Takai Y, Nemoto K, Yamada S.: "Univariate analysis of factors correlated with tumor control probability of three-dimensional conformal hypofractionated high-dose radiotherapy for small pulmonary or hepatic tumors"Int J Radiat Oncol Biol Phys. 58. 1114-1120 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nomiya T, Nemoto K, Ogawa Y, Takai Y, Yamada S.: "Relationships between radiosensitivity and microvascular density in esophageal carcinoma : significance of hypoxic fraction"Int J Radiat Oncol Biol Phys. 58. 589-596 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nemoto K, Matsushita H, Ogawa Y, Takeda K, Takahashi C, Britton KR, Takai Y, Miyazaki S, Miyata T, Yamada S.: "Radiation therapy combined with cis-diammine-glycolatoplatinum (Nedaplatin) and 5-fluorouracil for untreated and recurrent esophageal cancer"Am J Clin Oncol. 26. 46-49 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nemoto K, Seiji K, Sasaki K, Kasamtsu N, Fujishima T, Ogawa Y, Ariga H, Takeda K, Kimura T, Yamada S.: "A novel support system for patient immobilization and transportation for daily computed tomographic localization of target prior to radiation therapy"Int J Radiat Oncol Biol Phys. 55. 1102-1108 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ogawa Y, Nemoto K, Kakuto Y, Ariga H, Matsushita H, Takeda K, Takahashi C, Gallardo B, Rechard K, Takai Y, Yamada S.: "Results of radiation therapy for uterine cervical cancer using high dose rate remote after loading system"Tohoku J Exp Med. 199. 229-238 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kenji Nemoto: "A novel support system for patient immobilization and transportation for daily computed tomographic localization of target prior to radiation therapy"Int J Radiat Oncol Biol Phys. 55. 1102-1108 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kenji Nemoto: "Radiation therapy combined with cis-diammine-glycolatoplatinum (nedaplatin) and 5-Fluorouracil for untreated and recurrent esophageal cancer"Am J Clin Oncol. 26. 46-49 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kenji Nemoto: "Intraoperative radiation therapy (IORT) for previously untreated malignant gliomas"BMC Cancer. 2巻. 1-4 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kenji Nemoto: "Radiation therapy for limited-stage small-cell esophageal cancer"Am J Clin Oncol. 25巻. 404-407 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 根本建二: "最近の食道癌の放射線治療"日本医学放射線学会雑誌. 62巻. 132-137 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 根本建二: "食道表在癌の治療展望-放射線治療を中心に-"日本医学放射線学会雑誌. 62巻. 801-807 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 根本建二: "内科学書 改訂第6版、(島田 馨 編)"中山書店. 4 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Nemoto K.: "Intraoperative radiation therapy (IORT) for previously untreated malignant gliomas"BMC Cancer. 2. 1-5 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Nemoto K.: "Radiation therapy for loco regionally recurrent esophageal cancer after surgery"Radiother Oncol. 61. 165-168 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Nemoto K.: "Radiation therapy for superficial esophageal cancer : a comparison of radiotherapy methods"Int J Radiat Oncol Biol Phys. 50. 639-644 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Nemoto K.: "Apilot study of radiation therapy combined with daily low-dose cisplatin for esophageal canser"Oncol Rep. 8. 785-789 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Nemoto K.: "Phase Ia study of a hypoxic cell sensitizer doranidazole (PR-350) in combination with radiotherapy"Anticancer Drugs. 12. 1-6 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Nemoto K.: "Radiation therapy with uneven fractionation for malignant gliomas"Oncol Rep. 8. 103-106 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 根本建二: "放射線治療マニュアル"中外出版. 607 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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