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BASIC RESEARCH OF HIGH INTENSITY FUCUSED ULTRASOUND FOR HEPATIC TUMOR-EVALUATION OF TERATMENT EFFECT-

Research Project

Project/Area Number 13670954
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionSAPPORO MEDICAL UNIVERSITY

Principal Investigator

KOITO Kazumitsu  SAPPORO MEDIDAL UNIVERSITY, SCHOOL OF MEDICINE, ASSISTANT PROFESSOR, 医学部, 講師 (90153460)

Co-Investigator(Kenkyū-buntansha) NAGAKURA Hisayasu  SAPPORO MEDIDAL UNIVERSITY, SCHOOL OF MEDICINE, INSTRUCTOR, 医学部, 助手 (80244359)
HAREYAMA Masato  SAPPORO MEDIDAL UNIVERSITY, SCHOOL OF MEDICINE, PROFESSOR, 医学部, 教授 (10173098)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2002: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 2001: ¥1,700,000 (Direct Cost: ¥1,700,000)
Keywordsfocused ultrasound / hepatocellular carcinoma / apoptosis / 肝腫瘍 / 熱凝固
Research Abstract

1. Histopathological evaluation of high intensity focused ultrasound (HIFU) for normal skin and hepatic tumors.
HIFU was performed on the skin of the rats (five rats). Resected specimen of the skin and implanted KDH hepatoma in the skin of the rats. After irradiation of HIFU showed necrosis and sever inflammatory changes around the region. In addition, cell vacuolation and consendation of the nuclei were observed. Those findings were observed in both the normal skin and the implanted tumor.
2. Evaluation of HIFU for implanted WKAH hepatoma
HIFU was performed on implanted WHAH/HKm hepatoma of rats (mean diameter 3.6 mm). Complete necrosis was obtained by using 30w x 1.0 sec energy. On the contrary, no necrosis was obtained by less than 10w energy. HIFU group showed significantly (p<.05) longer survival compared with non-treatment group.
3. Apoptosis manifestation after HIFU
HIFU irradiaton was performed on culture cells of KDH-8 hepatoma. Immediately after that, apoptosis cell were stained by hekist 33258 fluorescence and were counted by the fluorescent microscope. Apoptosis was significantly (p<.05) appeared in the group of 30w energy more than one of 40w.
Those studies indicated that 1) HIFU induces necrosis of implanted hepatoma, 2) treatment effect depends on energy of HIFU, and 3) HIFU induces apoptosis by using appropriate energy.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (23 results)

All Other

All Publications (23 results)

  • [Publications] Koh-ichi Sakata, Yoshihisa Matsumoto, Hiroshi Tauchi, et al.: "Expression of genes involved in repair of DNA double-strand breaks in normal and tumor tissues"Int J Radiat Oncol Biol Phys. 49. 161-167 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Koh-ich Sakata, Yoshihisa Matusmoto, Masaaki Satoh, et al.: "Clinical studies of immunohistochemical staining of DNA-dependent protein kinase in oropharyngeal and hypopharyngeal carcinomas"Radiation Medecine. 19. 93-97 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tsutomu Namieno, Kazumitsu Koito, Masatoshi Takahashi, et al.: "Survival-associated histologic spreading modes of operable intrahepatic, peripheral-type cholangiocarcinomas"World J Surg. 25. 572-577 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Koito K, Ichimura T, Hirokawa N, Hareyama M, et al.: "Dynamic flow enhanced abdominal imaging"Diagnostic Imaging. 23(Suppl). 17-20 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sakata K, Nagakura H, Oouchi A, Someya M, et al.: "High-dose-rate intracavitary brachytherapy : results of analyses of late rectal complications"Int J Radiat Oncol Biol Phys. 54. 369-376 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hareyama M, Sakata K, Oouchi A, et al.: "High-dose-rate versus low-dose-rate intracavitary therapy for carcinoma of the uterine cervix : a randomized trial"Cancer. 94. 117-124 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Koh-ichi Sakata, Yoshihisa Matsumoto, Hiroshi Tauchi, Masaaki Satoh, Atsushi Ouchi, Hisayasu Nagakura, Kazumitsu Koito, Yoshio Hosoi, Norio Suzuki, Kenshi Komatsu, Masato Hareyama: "Expression of genes involved in repair of DNA double-strand breaks in normal and tumor tissues"Int J Radiat Oncol Biol Phys. 49(1). 161-167 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Koh-ichi Sakata, Yoshihisa Matsumoto, Hiroshi Tauchi, Masaaki Satoh, Atsushi Ouchi, Hisayasu Nagakura, Kazumitsu Koito, Yoshio Hosoi, Norio Suzuki, Kenshi Komatsu, Masato Hareyama: "Expression of genes involved in repair of DNA double-strand breaks in normal and tumor tissues"Int J Radiat Oncol Biol Phys. 49(1). 161-167 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tsutomu Namieno, Kazumitsu Koito, Masatoshi Takahashi, Yoshie Une, Kenichiro Yamashita, Tsuyoshi Shimamura: "Survival-associated histologic spreading modes of operable intrahepatic, peripheral-type cholangiocarcinomas"World J Surg. 25. 572-577 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Koito K, Ichimura T, Hirokawa N, Hareyama M: "Dynamic flow enhanced abdominal imaging"Diagnostic Imaging. 23(12)(Suppl). 17-20 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hareyama M, Sakata K, Oouchi A, Nagakura H, Shido M, Someya M, Koito K: "High-dose-rate versus low-dose-rate intracavitary therapy for carcinoma of the uterine cervix : a randomized trial"Cancer. 94(1). 117-124 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sakata K, Nagakura H, Oouchi A, Someya M, Nakata K, Shido M, Koito K, Sagae S, Kudo R, Hareyama M: "High-dose-rate intracavitary brachytherapy : results of analyses of late rectal complications"Int J Radiat Oncol Biol Phys. 54(5). 1369-1376 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Koh-ichi Sakata, Yoshihisa Matsumoto, Hiroshi Tauchi, et al.: "Expression of genes involved in repair of DNA double-strand breaks in normal and tumor tissues"Int J Radiat Oncol Biol Phys. 49. 161-167 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Koh-ich Sakata, Yoshihisa Matusmoto, Masaaki Satoh, et al.: "Clinical studies of immunohistochemical staining of DNA-dependent protein kinase in oropharyngeal and hypopharyngeal carcinomas"Radiation Medecine. 19. 93-97 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Tsutomu Namieno, Kazumitsu Koito, Masatoshi Takahashi, et al.: "Survival-associated histologic spreading modes of operable intrahepatic, peripheral-type cholangiocarcinomas"World J Surg. 25. 572-577 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Koito K, Ichimura T, Hirokawa N, Hareyama M, et al.: "Dynamic flow enhanced abdominal imaging"Diagnostic Imaging. 23(Suppl). 17-20 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Sakata K, Nagakura H, Oouchi A, Someya M, et al.: "High-dose-rate intracavitary brachytherapy : results of analyses of late rectal complications"Int J Radiat Oncol Biol Phys. 54. 369-376 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hareyama M, Sakata K, Oouchi A, et al.: "High-dose-rate versus low-dose-rate intracavitary therapy for carcinoma of the uterine cervix : a randomized trial"Cancer. 94. 117-124 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hareyama M: "High-dose-rate versus low-dose-rate intracavitary therapy for carcinoma of the uterine cervix : a randomized trial"Cancer. 33(8). 117-124 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Koito K: "Virtual CT cholangioscopy : comparison with fiberoptic cholangioscopy"Endoscopy. 33(8). 676-681 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Sakata K: "Clinical studies of immunohistochemical staining of DNA-dependent protein kinase in oropharyngeal and hypopharyngeal carcinomas"Radiat Med. 19(2). 93-97 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Namieno T: "Survival-associated histologic spreading modes of operable intrahepatic, peripheral-type cholangiocarcinomas"World J Surg. 25(5). 572-577 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Koito K: "Pancreas : imaging diagnosis with color/power Doppler ultrasonography, endoscopic ultrasonography, and intraductal ultrasonography"Eur J Radiol. 22(3). 94-104 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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