| Project/Area Number |
13670956
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
FUJII Hirotada Sapporo Medical University, School of Health Sciences, Professor, 保健医療学部, 教授 (70209013)
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| Co-Investigator(Kenkyū-buntansha) |
SHIRATO Hiroki Hokkaido University, Department of Radiology, Associate Professor, 医学部, 助教授 (20187537)
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| Project Period (FY) |
2001 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2002: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2001: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | free radicals / non-invasive visualization / ESR / oxygen / oximetry |
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| Research Abstract |
It would be very desirable to be able to measure directly the oxygen tension in tissues to assess their state and response to therapy. This would be especially desirable for planning and evaluating the radiation therapy for tumors and vascular insufficiencies.
The wide variety of techniques for measuring oxygen tensions in biological systems have been reviewed, but one of these methods has been demonstrated for the clinical use. Several NMR techniques have been studied recently, especially the use of an oxygen-dependent proton hyperfine line in myoglobin and oxygen-dependent relaxation of 19F. However, these approaches have not been demonstrated to have sufficient sensitivity and applicability for the real clinical use.
Electron paramagnetic resonance (EPR) oximetry is a technique which is based on the effect of molecular oxygen on the line width of EPR spectra of some paramagnetic materials.
In this project we used glucose char as the paramagnetic materials and examined its following characterizations : accuracy, sensitivity, ease to use, toxicity, and stability in vivo. From our results, the glucose char appears to have the very good properties than other reported paramagnetic materials.
The EPR oximetry using the glucose char will be promising method to measure oxygen tensions in vivo.
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