| Project/Area Number |
13670981
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Psychiatric science
|
|---|
| Research Institution | University of Tsukuba |
|---|
Principal Investigator |
HORI Takafumi Department of Psychiatry, Institute of Clinical Medicine, 臨床医学系, 講師 (40241822)
|
|---|
| Project Period (FY) |
2001 – 2002
|
| Project Status |
Completed (Fiscal Year 2002)
|
| Budget Amount *help |
¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2002: ¥1,500,000 (Direct Cost: ¥1,500,000)
|
|---|
| Keywords | Schizophrenia / neurodevelopment / ventral hippocampus / cocaine / behavioral sensitization / rat / ラット / 統合失調症 / 服側海馬 |
|---|
| Research Abstract |
Rat with neonatal ventral hippocampal lesion (NVHL) has been studied as a neurodevelopmental animal model of schizophrenia. Psychostimulants such as cocaine and amphetamine induce behavioral sensitization, which has been studied as a pharmacological animal model of schizophrenia. The phenomenon of behavioral sensitization is thought to be analogous to exacerbation in schizophrenic patient. In order to investigate whether psychostimulant induces behavioral sensitization in NVHL rat, cocaine (20mg/kg, i.p.) was treated for 7 days in NVHL rat after puberty. According to the method of Lipska (1993), Male Sprague-Dawley pups were lesioned by ibotenic acid on postnatal day 7(PD 7). All experiments were approved by the University of Tsukuba animal experiment committee.
Cocaine increased locomotor activity in NVHL rat in postpuberty (PD 49) but not in prepuberty (PD35), which confirmed previous reports. Cocaine induced behavioral sensitization in both sham and lesioned rats. Stereotyped behaviors in lesioned rat continued for long time comparing with that in sham rat. These results indicate that combination with continuous cocaine treatment and NVHL in rat has possibility as a new animal model including mechanisms of onset and exacerbation of schizophrenia.
|
