| Project/Area Number |
13670985
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
FUKUDA Rimmei The University of Tokyo, Faculty of Medicine, Lecturer, 医学部附属病院, 講師 (60246048)
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| Co-Investigator(Kenkyū-buntansha) |
KUROKI Noriomi The University of Tokyo, Faculty of Medicine, Research Associate, 医学部附属病院, 助手 (40322052)
ABE Osamu The University of Tokyo, Faculty of Medicine, Lecturer, 医学部附属病院, 講師 (50302716)
IWANAMI Akira The University of Tokyo, Faculty of Medicine, Associate Professor, 医学部附属病院, 助教授 (80276518)
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| Project Period (FY) |
2001 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 2002: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2001: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Keywords | Magnetic Resonance Imaging / Alcohol / Drinking / Brain Atrophy / Statistical Parametric Mapping / International Research Collaboration / United Kingdom |
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| Research Abstract |
In the present study, the effect of common usage of alcohol on the brain is evaluated using high-resolution magnetic resonance imaging and voxel-based morphometry. The aim is to clarify the effect of alcohol on the alteration of brain morphology associated with aging and to investigate the possibility of the prevention of the deterioration of mental function by changing the life habit.
Our results confirmed the previous findings that by aging brain volume is reduced mainly in frontal and temporal lobes. Moreover, our results suggested that the more the amount of drinking, the more the reduction of the prefrontal gray matter volume. Also, the effect of aging is reduced if the effect of alcohol intake is removed.
In conclusion, we found that even common usage of alcohol will affect the morphological changes in the brain and the possibility of reduction of this effect by limiting the alcohol intake is suggested. We plan to expand our investigation on more extensive range of alcohol consumption and test the effect of those morphological changes on brain function including memory and executive function.
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