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BIOLOGICAL BASIS OFTHE PSYCHOSOCIALTREATMENTFOR SCHIZOPHRENIA

Research Project

Project/Area Number 13670993
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionToyama Medical and Pharmaceutical University

Principal Investigator

KAWASAKI Yasuhiro  TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY HOSPITAL, ASSISTANT PROFESSOR, 附属病院, 講師 (80242519)

Co-Investigator(Kenkyū-buntansha) TSUNODA Masahiko  TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY HOSPITAL, INSTRUCTOR, 附属病院, 助手 (30322762)
SUZUKI Michio  TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY, FACULTY OF MEDICINE, ASSOCIATE PROFESSOR, 医学部, 助教授 (40236013)
KURACHI Masayoshi  TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY, FACULTY OF MEDICINE, PROFESSOR, 医学部, 教授 (80019603)
MATSUI Mie  TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY, FACULTY OF MEDICINE, ASSOCIATE PROFESSOR, 医学部, 助教授 (70209485)
HAGINO Hirofumi  TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY, FACULTY OF MEDICINE, INSTRUCTOR, 医学部, 助手 (10272915)
田尻 浩嗣  富山医科薬科大学, 医学部, 助手 (80345579)
野原 茂  富山医科薬科大学, 附属病院, 助手 (90324053)
Project Period (FY) 2001 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2003: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2002: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2001: ¥1,100,000 (Direct Cost: ¥1,100,000)
Keywordsneuropsychiatry / schizophrenia / schizotypal disorder / psychosocial treatment / neuroimaging / magnetic resonance imaging / neuropsychology / neurophysiology / 精神分裂病(統合失調症) / 分裂病型障害(統合失調型障害) / 神経心理検査 / 精神分裂病 / 分裂病型障害
Research Abstract

In order to elucidate the biological basis of the psychosocial treatment for schizophrenia, structural and physiological neuroimaging studies were conducted using the Statistical Parametric Mapping(SPM) 99. A comprehensive assessment throughout the brain using the voxel-based morphometry showed structural differences in the gray matter of magnetic resonance imaging(MRI). Results indicated that schizotypal disorder possesses similar but less extent morphological abnormalities to schizophrenia. Observed commonalities of gray matter reductions in the orbital frontal, medial temporal and periventricular regions may represent the vulnerability to schizophrenia, and additional involvement of the medial frontal regions may be essential to develop the florid psychotic symptoms in schizophrenia. These suggested the temporo-frontal two-step processes for the development of schizophrenia : the temporal lobe changes may constitute vulnerability to schizophrenia and additional changes in the fronta … More l lobes may elicit psychotic symptoms. Moreover, we studied the possibility of diagnosis of schizophrenia using neuroimaging methods. A principal component analysis of SPM99 extracted patterns of gray matter changes differentiating most among schizophrenia, schizotypal, and control subject groups. The first pattern separated patient scans from healthy comparison scans, and the second pattern discriminated patients with schizophrenia from patients with schizotypal disorder. The auditory event-related potential was evaluated using the Low Resolution Electromagnetic Tomography(LORETA). Patterns of cortical activation maxima in the P300-timeframe differentiating schizophrenia patients from controls were extracted using a principal component analysis. Neurophysiological pattern also demonstrated pathognomonic abnormalities in the medial prefrontal region. These results indicate that the neuroimaging approach to elucidate brain pathologies of schizophrenia spectrum disorder might be of value for clinical diagnosis. Less

Report

(4 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (17 results)

All Other

All Publications (17 results)

  • [Publications] 川崎康弘ら: "今すぐ精神科臨床に使える脳イメージング:精神分裂病"精神科治療学. 16・10. 983-989 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 川崎康弘ら: "臨床検査による精神科診断はどこまで可能となった:形態画像"精神科診断学. 13・2. 145-152 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 川崎康弘: "統合失調症の認知障害と前頭葉"臨床精神医学. 32・4. 369-375 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 川崎康弘: "統合失調症の発症に関連する脳形態異常"臨床脳波. 45・11. 689-694 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yasuhiro Kawasaki, et al.: "Possibility of early diagnosis of schizophrenia by three-dimensional magnetic resonance imaging.In Recent Advances in Early Intervention and Prevention in Psychiatric Disorders."星和書店. 321 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yasuhiro K et al.: "Schizophrenia"Japanese Journal of Psychiatric Treatment. 16. 983-989 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yasuhiro K et al.: "Structural neuroimaging."Archives of Psychiatric diagnostics and clinical evaluation. 13. 145-152 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kawasaki Y: "Cognitive dysfunction and frontal lobe in schizophrenia."Japanese Journal of Clinical Psychiatry. 32. 369-375 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kawasaki Y: "Structural abnormalities relevant to the onset of schizophrenia."Clinical Electroencephalography. 45. 689-694 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yasuhiro K et al.: "Possibility of early diagnosis of schizophrenia by three-dimensional magnetic resonance imaging."Recent Advances in Early Intervention and Prevention in Psychiatric Disorders, (Seiwa Shoten Publishers). 321 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 川崎康弘: "統合失調症の認知障害と前頭葉"臨床精神医学. 32・4. 369-375 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 川崎康弘: "統合失調症の発症に関連する脳形態異常"臨床脳波. 45・11. 689-694 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 川崎康弘: "臨床検査による精神科診断はどこまで可能となったか:形態画像"精神科診断学. 13・2. 145-152 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yasuhiro Kawasaki, et al.: "Structural brain differences in patients with schizotypal disorder and schizophrenia using voxel-based morphometry"Schizophrenia Research. 53・3. 92 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yasuhiro Kawasaki, et al.: "Anomalous cerebral structural asymmetry in patients with schizophrenia demonstrated by voxel-based morphometry"European Neuropsychopharmacology. 12・3. 295 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yasuhiro Kawasaki, et al.: "Possibility of early diagnosis of schizophrenia by three-dimensional magnetic resonance imaging. In Recent Advances in Early Intervention and Prevention in Psychiatric Disorders"星和書店. 321 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 川崎康弘, 中村主計, 鈴木道雄, 倉知正佳: "今すぐ精神科臨床に使える脳イメージング 精神分裂病"精神科治療学. 16巻10号. 983-989 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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