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The effects of repetitive transcranial magnetic stimulation on neurogenesis

Research Project

Project/Area Number 13671001
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionOsaka University

Principal Investigator

UKAI Satoshi  Osaka University, Graduate School of Medicine, Assistant Professor, 医学系研究科, 助手 (80324763)

Co-Investigator(Kenkyū-buntansha) TAKEDA Masatoshi  Osaka University, Graduate School of Medicine, Professor, 医学系研究科, 教授 (00179649)
KUDO Takashi  Osaka University, Graduate School of Medicine, Associate Professor, 医学系研究科, 助教授 (10273632)
SHINOSAKI Kazuhiro  Osaka University, Graduate School of Medicine, Associate Professor, 医学系研究科, 助教授 (40215984)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2002: ¥1,100,000 (Direct Cost: ¥1,100,000)
KeywordsTMS / neurogenesis / HFOs / SEPs / 神経細胞新 / うつ病
Research Abstract

The basis for therapeutic effect and optimum stimulus condition of rTMS (repetitive transcranial magnetic stimulation) is still unknown. We investigated the therapeutic mechanisms of rTMS in the light of neurogeneais in the dentate gyrus of the rats and the modulation of HFOs (high frequency oscillations) in the healthy human subjects.
1. We aimed to examine the possibility that rTMS triggers hippocampal neurogenesis, and if so, to obtain optimum rTMS stimulus condition using neurogenesis as an indicator. Rats were given either real or sham rTMS. For the real rTMS group, rTMS was administered (10 Hz, 150 pulses, 120% motor threshold /day) for 14 days and the two groups were compared. The effects of rTMS .on neurogenesis in the dentate gyrus using bromodeoxyuridine (BrdU) immunohistochemistry, which identifies newly generated cells. Cells were labeled for neuronal nuclear protein (NeuN) to identify neurons.
2. HFOs of SEPs (somatosensory evoked potentials) in 7 healthy human subjects were recorded before and after the slow rTMS on the primary sensory area (0.5 Hz, 50 pulses, 80% motor threshold). 6 of the 7 subjects showed significant increase of the amplitude and the power of HFOs after rTMS, while no subjects showed after sham rTMS. These results suggest that slow rTMS might directly increase the activity of GABAergic inhibitory interneurons in the cortex and suppress cortical excitability through these inhibitory interneurons. Studies of HFOs changes with other rTMS conditions are needed to obtain the optimum stimulus condition.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (25 results)

All Other

All Publications (25 results)

  • [Publications] Satoshi Ukai: "Parallel distributed processing neuroimaging in the Stroop task using spatially filtered magnetoencephalography analysis"Neuroscience Letters. 334. 9-12 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Shunsuke Kawaguchi: "Interictal spikes in the fusiform and inferior temporal gyri of an epileptic patient with colored elementary visual auras : a 5-year longitudinal MEG ECD study"Neuroreport. 14. 637-640 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ryouhei Ishii: "MEG study of long-term cortical reorganization of sensorimotor areas with respect to using chopsticks"Neuroreport. 13. 2155-2159 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 篠崎和弘: "ECTとTMSの認知機能に及ぼす影響"臨床精神医学. 32. 283-288 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 鵜飼聡: "空間フィルタによる統合失調症(精神分裂病)の脳磁図解析"臨床脳波. 44. 789-794 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] K.Hirata: "Recent Advances in Human Brain Mapping"Elsevier. 936 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Satoshi Ukai, Kazuhiro hinosahi, Ryouhei Ishii, Asao Ogawa, Yuko Mizuno-Matsumoto, Tsuyoshi Inouye, Norio Hirabuki, Toshiki Yoehimine, SE Robinson, Masatoshi Takeda: "Parallel distributed processing neuroimaging in the Stroop task using spatially filtered magnetoencephalography analysis."Neuroscience Letters. 334. 9-12 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Shunsuke Kawagachi, Kazuhiro hinosaki, Satoshi Ukai, Ryouhei Iahii, Masakiyo Yamamoto, Asao Ogawa, Norihiko Fujita, Toshiki Yoshimine, Masatoshi Takeda: "Interictal spikes in the fusiform and inferior temporal gyri of an epileptic patient with colored elementary visual auras a 5-year longitudinal MEG ECD study"Neuroreport. 14. 637-640 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ryouhei Ishii, Matthias Schulz, Jing Xiang, asatoshi Takeda, Kazuhiro Shinosaki, Donald T Stuss, Christo Pantev: "MEG study of long-term cortical reorganization of sensorimotor areas with respect to using chopsticks."Neuroreport. 13. 2155-2159 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Satoshi Ukai, Kazuhiro hinosaki, Ryouhei Ishii, Yuko-Mizuno atsumoto, Tsuyoahi Inouye, Norio Hirabuki, Toshiki Yoshimine, SE Robinson, Masatoshi Takeda In K. Miyoshi, CM Shapiro, M Gaviria, Y Morita (Eds.): "MEG functional neuroimaging of schizophrenic patients and comparison subjects during word generation, Contemporary Neuropsychiatry"Springer*Verlag. 39-45 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Satoshi Ukai, Kazuhiro hinosaki, Ryouhei Ishii, Asao Ogawa, Yuko Mizuno-Matsumoto, Tuyoshi Inouye, Norio Hirabuki, Toshiki Yoshimine, S.E. Robinson, Masatoshi Takeda, In K. Hirata, Y. Koga, K. Nagata, K. Yamazaki (Eds.): "Spatially Filtered MEG Analysis Estimates Propagation of Cortical Activities During The Stroop Task.,Recent Advances in Human Brain Mapping"Elsevier. 409-413 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Satoshi Ukai: "Parallel distributed processing neuroimaging in the Stroop task using spatially filtered magnetoencephalography analysis"Neuroscience Letters. 334. 9-12 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Shunsuke Kawaguchi: "Interictal spikes in the fusiform and inferior temporal gyri of an epileptic patient with colored elementary visual auras : a 5-year longitudinal MEG ECD study"Neuroreport. (in press).

    • Related Report
      2002 Annual Research Report
  • [Publications] Ryouhei Ishii: "MEG study of long-term cortical reorganization of sensorimotor areas with respect to using chopsticks"Neuroreport. 13. 2155-2159 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 鵜飼聡: "空間フィルタによる統合失調症(精神分裂病)の脳磁図解析"臨床脳波. 44. 789-794 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 鵜飼聡: "てんかん精神病"臨床脳波. 44. 524-531 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hiroshi Mori: "Expression of mouse igf2mRNA-binding protein 3 and its implication for the developing central nervous system"Journal of Neuroscience Research. 64. 132-143 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] K.Hirata, Y.Koga, K.Nagata, K.Yamazaki: "Recent Advances in Human Brain Mapping"Elsevier. 936 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yuko Mizuno-Matsumoto: "Transient Global Amnesia(TGA)in an MEG Study"Brain Topography. 13・4. 269-274 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Hiroshi Mori: "Expression of mouse igf2mRNA-binding Protein 3 and its implication for the developing central nervous system"Journal of Neuroscience Research. 64. 132-143 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yuko Mizuno-Matsumoto: "Landau-Kleffner syndrome : localization of epileptogenic lesion using wavelet-cross-correlation analysis"Epilepsy&Behavior. 2. 288-294 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 鵜飼聡: "MEGによる言語の脳機能局在の可視化-空間フィルタ法による解析-"臨床脳波. 43・7. 430-435 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 篠崎和弘: "痴呆の精神生理学的アプローチ"老年精神医学雑誌. 12・6. 619-625 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 篠崎和弘: "精神分裂病のMEG研究"精神科治療学. 16・10. 1055-1061 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Koho Miyoshi: "Contemporary Neuropsychiatry"Springer-Verlag. 478 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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