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A Polysomnographic Study on Refractory Akathisia and Restless Legs Syndrome- Algorithm of Drug Treatment focused Nocturnal Myoclonus -

Research Project

Project/Area Number 13671006
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionSHIMANE MEDICAL UNIVERSITY

Principal Investigator

HORIGUCHI Jun  SHIMANE MEDICAL UNIVERSITY, DEPARTMENT OF PSYCHIATRY, PROFESSOR, 医学部, 教授 (90136317)

Co-Investigator(Kenkyū-buntansha) MIYAOKA Tuyoshi  SHIMANE MEDICAL UNIVERSITY, DEPARTMENT OF PSYCHIATRY, ASSISTANT LECTURER, 医学部, 助手 (50284047)
MIZUNO Soichi  SHIMANE MEDICAL UNIVERSITY, DEPARTMENT OF PSYCHIATRY, ASSISTANT LECTURER, 医学部, 助手 (80335562)
INAGAKI Takuji  SHIMANE MEDICAL UNIVERSITY, DEPARTMENT OF PSYCHIATRY, ASSOCIATE PROFESSOR, 医学部, 助教授 (80176388)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2002: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2001: ¥1,800,000 (Direct Cost: ¥1,800,000)
Keywordsrestless legs / polysomnography / sleep / low serum iron / akathisia / iron / ferritin / transferrin / 難治性アカシジア / 睡眠時ミオクローヌス / 周期性四肢運動障害 / 精神科薬物療法
Research Abstract

1) Schizophrenic patients with akathisia demonstrated high frequency of PLM index and arousal index, and low attitude of inter-movement interval, SWS, and ST, comparing with the controls.
2) Schizophrenic patients afrer akathisia treatment showed low frequency of PLM index and arousal index, and high attitude of TST, SWS and Inter-movement interval.
3) Patients with idiopathic RLS showed low brain iron concentration.
4) The blunted serum to CSF ferritin relationship seen in the RLS group suggests a dysfunction of iron transport from serum to CNS.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (31 results)

All Other

All Publications (31 results)

  • [Publications] 水野創一ほか: "Clonazepamの薬原性錐体外路症状に対する有効性"臨床精神薬理. 5巻. 529-536 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yamashita H ほか: "Effect of risperidone on sleep in schizophrenia : a comparison with haloperidol"Psyciatry Research. 109巻. 137-142 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Miyaoka T ほか: "Late-onsets schizophrenia with epileptiform discharge : a case report"Search on epilepsy. 9巻・4号. 13-15 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 宮岡 剛 ほか: "出雲プロジェクト(第2報)Restless Legs症候群と他の睡眠障害との関連"精神医学. 44巻・10号. 1095-1100 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 稲見康司ほか: "身体疾患に伴ううつ状態/薬物によるうつ状態"精神科治療学. 17巻・増刊. 267-271 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 堀口 淳 ほか: "臨床睡眠医学の進歩"Pharma Medica. 20巻・Suppl. 47-50 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 堀口 淳: "高齢者の不眠の実態と治療例(分担執筆) 不眠症・睡眠障害における私の処方"診療新社. 3 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Miyaoka T, Seno H, Itoga M, Kishi T, Ishimo H, Horiguchi J: "Contribution of sodium valproate to the syndrome of inapproprate secretion of antidiuretic hormone"International Clinical Psycnopharmacology. 16. 59-61 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Miyaoka T, Seno H, Itoga M, Ohshiro R, Inagaki T, Horiguchi J: "Chilaiditi syndorome-associated schizophrenia:3 case reports"Journal of Clinical Psychiatry. 62. 58-59 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Miyaoka T, Seno H, Yamamori C, Iijima M, Inagaki T, Horiguchi J: "Late-onset schizophrenia with epileptiform dscharge"International Journal of Psychiatry in Clinical Practice. 5. 67-70 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sasaki Y, Hayakawa H, Kagaya A, Horiguchi J, Yamawaki S: "Effect of forced running stress on behavior and on brain serotonin system in rats"Biogenic Amines. 16. 137-155 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Miyaoka T, Seno H, Yamamori C, Inagaki T, Ioga M, Tsubouchi K, Horiguchi J: "Pisa syndrome due to a Cholinesterase inhibitor (donepezil) : a case report"Journal of Clinical Psychiatry. 62. 573-574 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Miyaoka T, Seno H, Inagaki T, Ioga M, Inagaki T, Horiguchi J: "Structural brain changes in schizophrenia associated with idiophathic unconjugated hyperbilirubinemia (Gilbert syndrome): a planimetric CT study"Schizophrenia Research. 52. 291-293 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Mori K, Yamashita H, Nagano M, Horiguchi J, Yamawaki S: "Effect of anticholinergic drug withdrawal on memory, regional cerebral blood flow and extrapyramidal side effects in schizophrenic patients"Pharmacopsychiatry. 35. 6-11 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yamashita H, Morinobu S, Yamawaki H, Horiguchi J, Nagano M: "Effect of risperidone on sleep in schizophrenia: a comparison with haloperidol"Psyciatry Research. 109. 137-142 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Inagaki T, Horiguchi J, Tsubouchi K, Miyaoka T, Uegaki J, Seno H: "Late onset anorexia nervosa: two case reports"International Journal of Psychiatry in Medicine. 32. 91-95 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Miayoka T, Yamamori C, Inagaki T, Horiguchi J: "Late-onset schizophrenia with epileptiform discharge: a case report"Search on epilepsy. 9(4). 13-15 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Inagaki T, Yamamoto M, Tsubouchi K, Miyaoka T, Uegaki J, Maeda T, Horiguchi J, Yamane Y, Kato Y: "Echocardiographic Investigation of precardial effusion in a case of anorexia nervosa"International Journal Eat Disorder. 33. 364-366 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 水野創一ほか: "Clonazepamの薬原性錐体外路症状に対する有効性"臨床精神薬理. 5巻. 529-536 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 堀口 淳ほか: "Restless Legs症候群と血清鉄との関係"島根難病研究所平成13年度研究報告集. 67-68 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 助川鶴平ほか: "精神科薬物療法の留意点"精神科臨床サービス. 2巻. 510-511 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 宮岡 剛ほか: "出雲プロジェクト(第2報)Restless Legs症候群と他の睡眠障害との関連"精神医学. 44巻・10号. 1095-1100 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 稲見康司ほか: "身体疾患に伴ううつ状態/薬物によるうつ状態"精神科治療学. 17巻・増刊. 267-271 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 堀口 淳ほか: "臨床睡眠医学の進歩"Pharma Medica. 20巻・Suppl. 47-50 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 堀口 淳: "高齢者の不眠の実態と治療例(分担執筆)不眠症・睡眠障害における私の処方"診療新社. 3 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 糸賀 基: "出雲プロジェクト(第1報)〜出雲市における高齢者睡眠アンケート調査について〜"精神医学. 44巻4号(発表予定). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] 宮岡 剛: "錐体外路症状の徹底比較"臨床精神薬理. 5・2. 177-183 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Tsuyoshi Miyaoka: "Structural brain changes in schizophrenia associated with idiopathic unconjugater hyperbilirubinemia (Gilber't syndrome) :a planimetric CT study"Schizophrenia Research. 52・3. 291-293 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Tsuyoshi Miyaoka: "Late-onset schizophrenia with epileptiform discharge"International Journal of Psychiatry in Clinical Practice. 5. 67-70 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Tsuyoshi Miyaoka: "Chilaiditi syndrome-associated schizophrenia:3 case reports"Journal of Clinical Psychiatry. 62・7. 58-59 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 堀口 淳: "抗精神病薬の副作用 今日の治療指針 2002年版"医学書院. 3 (2002)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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