| Project/Area Number |
13671017
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | OITA MEDICAL UNIVERSITY |
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Principal Investigator |
AKIYOSHI Jotaro Oita Medical University, Neuropsychiatry, Associate Professor, 医学部, 助教授 (00159344)
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| Co-Investigator(Kenkyū-buntansha) |
NAGAYAMA Haruo Oita Medical University, Neuropsychiatry, Professor, 医学部, 教授 (70100899)
ISOGAWA Koichi Oita Medical University, Neuropsychiatry, Assistant, 医学部, 助手 (10264334)
堀之内 由起子 大分医科大学, 医学部, 助手 (50305041)
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| Project Period (FY) |
2001 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2002: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 2001: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | transcranial magnetic stimulation / rat / conditoned fear / anxiety / black and white test / elevated plus maze / 明暗箱 / 不安 / モデル動物 / ベンゾジアゼピン / 抗うつ薬 / CRF / レセプター / アンチセス |
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| Research Abstract |
Repetitive transcranial magnetic stimulation (rTMS) has been shown to have a therapeutic effect on affective disorder and anxiety disorders. However, some reports have linked rTMS to a significant increase in anxiety in normal volunteers. This study investigated the effect of rTMS on anxiety and the use of acute and chronic paroxetine treatment on this animal model of anxiety. In normal rats, rTMS for 10 days induced anxiety, as shown by elevated plus maze, black and white box, and conditioned fear tests. This anxiety was suppressed by chronic paroxetine, acute diazepam, alprazolam and buspirone but not acute paroxetine treatment. These results suggest that rate receiving chronic rTMS treatment can be used as a model of anxiety and that the anxiety induced by rTMS might involve the serotonergic and GABA system.
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