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Research on Development and Validity of New Therapeutic Strategy for Anorexia Nervosa

Research Project

Project/Area Number 13671020
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionKagoshima University

Principal Investigator

NOZOE Shin-ichi  Kagoshima University, Graduate School of Medical and Dental Sciences, Professor, 大学院・医歯学総合研究科, 教授 (10117533)

Co-Investigator(Kenkyū-buntansha) NARUO Tetsuro  Kagoshima University, Graduate School of Medical and Dental Sciences, Associate Professor, 大学院・医歯学総合研究科, 助教授 (70244233)
松本 聰子  鹿児島大学, 医学部・附属病院, 助手 (90305136)
Project Period (FY) 2001 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 2003: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2002: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2001: ¥1,000,000 (Direct Cost: ¥1,000,000)
Keywordsanorexia nervosa / bulimia nervosa / starvation / chronicity / team approach / stress coping / bringing-up experience / early prevention / 摂食障害 / グレリン / 治療プログラム / EMBU / 神経症過食症 / ghrelin / 家族療法 / 自律神経機能 / 脳血流 / 文化変容 / 糖負荷試験
Research Abstract

1)Examination about chronic patients with eating disorders (ED) whose ill period passed ten years or more :
Among 31 patients with chronic ED we found 7 restrictive anorexia nervosa patients (AN-R), 12 anorexia nervosa with binge eating and purging (AN-BP), 6 bulimia nervosa with purging (BN-P), 1 bulimia nervosa without purging (BN-NP) and 5 eating disorders not otherwise specified (EDNOS). These findings indicate that more than 80% of the chronic patients are exposed to long term of severe malnutrition which have great impact on physiological and psychological state relating with abnormal eating.
2)Examination about an eating disorder patient's bringing-up experience :
As compared with the control group, "refusal" of the ED group was significantly higher in the father and the mother, and the patients did not feel "emotion-warmth". Moreover, the father's (results serious consideration) and (excessive meddling) of "overprotection" were significantly low, and the father thought that unconcern and an attitude (presence is thin) of noninterference were taken.
3)Proposal about the new medical treatment program based on the research results :
Since the action by disorder of the mind-and-body balance by repetition of overeating and vomiting makes correspondence much more difficult, it is better to consider the team medical treatment by the hospitalization which that it can do burns. Thus, the early treatment by early detection is most important and effective and parents who have familiar problems should also be supported from the side.

Report

(4 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (29 results)

All Other

All Publications (29 results)

  • [Publications] Naruo T, Nakabeppu Y, Deguchi D, Nagai N, Tsutsui J, Nakajo M, Nozoe S: "Decreases in blood perfusion of the anterior cingulate gyri in Anorexia Nervosa Restricters assessed by SPECT image analysis"BMC Psychiatry. 1. 2 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nagai N, Naruo T, Homan H, Tatebe Y, Muranaga T, Munemoto T, Yasuhara D, Deguchi D, Nozoe S: "Effectiveness of multidisciplinary team approach and prognosis of inpatients with eating disorders."Psycho-neuro-endocrino-immunology. 1241. 137-141 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tanaka M, Naruo T, Nagai N, Kuroki N, Shiiya T, Nakazato M, Matsukura S, Nozoe S: "Habitual binge/purge behavior influences circulating ghrelin levels in eating disorders."Journal of Psychiatry Research. 37. 17-22 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yasuhara D, Naruo T, Nagai N, Tanaka M, Muranaga T, Nozoe S: "Insulinogenic index at 15 min as a marker of nutritional rehabilitation in anorexia nervosa."American Journal of Clinical Nutrition. 77. 292-299 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Naruo T, Nakabeppu Y, Deguchi D, Nagai N, Tsutsui J, Nakajo M, Nozoe S: "Decreases in blood perfusion of the anterior cingulate gyri in Anorexia Nervosa Restricters assessed by SPECT image analysis"BMC Psychiatry. 1. 2 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nagai N, Naruo T, Homan H, Tatebe Y, Muranaga T, Munemoto T, Yasuhara D, Deguchi, D, Nozoe S: "Effectiveness of multidisciplinary team approach and prognosis of inpatients with eating disorders."Psycho-neuro-endocrino-immunology. 1241. 137-141 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tanaka M, Naruo T, Nagai N, Kuroki N, Shiiya T, Nakazato M, Matsukura S, Nozoe S: "Habitual binge/purge behavior influences circulating ghrelin levels in eating disorders."Journal of Psychiatry Research. 37. 17-22 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yasuhara D, Naruo T, Nagai N, Tanaka M, Muranaga T, Nozoe S: "Insulinogenic index at 15 min as a marker of nutritional rehabilitation in anorexia nervosa."American Journal of Clinical Nutrition. 77. 292-299 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yasuhara D, Nozoe S, et al.: "Insuligenic index at 15 min asa maker of nutritional rehabilitation in anorexia nervosa"American Journal of Clinical Nutrition. 77・2. 292-299 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yasuhara D, Nozoe S, et al.: "A characteristic reactive hypoghycemia induced by rapid change of eating behavior in anorexia nervosa"International Journal of Eating Disorders. 34・2. 273-277 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Tanaka M, Nozoe S, et al.: "Fasting plasma ghrelin levels in subtypes of anorexia nervosa"Psychoneuroendocrinology. 28・7. 829-835 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Tanaka M, Nozoe S, et al.: "Habitual binge/purge behavior influences circulating ghrelin levels in eating disorders"Journal of Psychiatric Research. 37・1. 17-22 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Tanaka M, Nozoe S, et al.: "Eating pattern and the effect of oral glucose on ghrelin and insulin secretin in patients with anorexia nervosa"Clinical Endocrinolosy. 54・5. 574-579 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 中井義勝, 野添新一, 他: "摂食障害の臨床像についての全国調査"心身医学. 42・11. 729-737 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 野添新一, 村永鉄郎他: "今日の病態栄養療法(摂食障害)"南江堂. 6 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Tanaka M, Nozoe S, et al.: "Increased fasting plasma ghrelin levels in patients with bulimia nervosa"Journal of clinical Endocrinology & Metabolism. 146. R1-R3 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yasuhara D, Nozoe S, et al.: "Insulinogenic index at 15 minutes as a marker of nutritional rehavilitation in anorexia nervosa"The American Journal of Clinical Nutrition. (In press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Tanaka M, Nozoe S: "Habitual binge/purge behavior influences circulating ghrelin levels in eating disorders"Journal of Psychiatric Research. 37. 17-22 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Tanaka M, Nozoe S: "Fasting plasma levels ghrelin levels in subtypes of anorexia nervosa"Psychoneuroendocrinology. (In press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] 建部佳記, 野添新一, ほか: "当科にて入院行動療法を行った摂食障害患者の予後に関する調査研究"心身医学. 42・10. 661-668 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 安原大輔, 野添新一, ほか: "神経性食欲不振症患者における入院適応を規定するための重症度スコア作成の試み"心身医学. 42・10. 653-660 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 野添新一: "今日の消化器疾患 治療指針 摂食障害"医学書院. 211-214 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Naruo. T: "Decreases in blood perfusion of anterior cingulated gyri in anorexia nervosa assessed by SPECT image analysis"BMC Psychiatry. 1・2. (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 中別府良昭, 野添新一他: "神経性食欲不振症患者の脳血流SPECT : Statistical Parametric mapping(SPM96)での研究"臨床放射線. 46. 199-201 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 中山孝史, 野添新一: "神経性食欲不振症-疫学、病因、病態、治療"日本臨床. 59. 534-539 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 松本聰子: "体型や食事に対する信念尺度作成の試み:摂食障害における思考パターンを探る"心身医学. 41・5. 335-342 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 松本聰子: "摂食障害の各サブタイプにおける認知的障害は同じか-認知行動からの検討"心身医学. 41・7. 529-537 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 成尾鉄朗: "摂食障害の画像解析研究"心身医学. 41. 327-334 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Naruo.T: "Eating Disorders : Brain Imaging in Textbook Biological Psychiatry"(ED)D'huenen H, Boer JA, Westenberg H, and Williner, London(In press). (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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