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Sensory Gating of the P50 Midlatency Auditory Evoked Potential in Schizophrenics

Research Project

Project/Area Number 13671022
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionUniversity of the Ryukyus

Principal Investigator

MIYAZATO Hiroshi  Univ. of the Ryukyus, School of Medicine, Instructor, 医学部, 助手 (80244333)

Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥2,600,000 (Direct Cost: ¥2,600,000)
Fiscal Year 2002: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2001: ¥2,100,000 (Direct Cost: ¥2,100,000)
KeywordsSchizophrenia / Schizotypy / Auditory evoked potential / Sensory gating / P50 suppression / 事象関連電位 / sensory gating / P50 / P300
Research Abstract

Background: Certain neuropsychiatric diseases are characterized, or even presaged, by disturbances in sleep-wake control and arousal, functions of the reticular activating system (RAS). One measure of RAS function is the P50 midlatency auditory evoked potential. Using a paired stimulus paradigm, the amplitude of the first response is a measure of the initial responsiveness of the system, while the ratio of the two responses at a short interstimulus interval is a measure of sensory gating. Methods: Sensory gating [(P50_<S2>/P50_<S1>)X100 (%)] was obtained from schizophrenics (n=27) and healthy volunteers (n=27). In addition, Positive and Negative Syndrome Scale (PANSS) and Schizotypal Personality Questionnaire (SPQ) were administered to schizophrenics and healthy volunteers, respectively. Results: (i) P50 sensory gating in schizophrenics (84.4±58.3) differed significantly (p<0.001) from that in normal subjects (20.9±20.1). (ii) In schizophrenics, P50 sensory gating did not correlate with any PANSS score. (iii) In healthy volunteers, sensory gating had significant correlation with both total SPQ scores (r=0.525, p=0.001) and withdrawn factor scores (r=0.486, p=0.004). (iv) When normal subjects were divided into low (<12) and high (≧13) SPQ score groups, sensory gating in high SPQ score group was significantly higher (poorer) than that in low SPQ score group (Z=3.40, p=0.001). Conclusions: Consistent with the previous reports, P50 gating deficits were demonstrated in schizophrenic patients. In normal subjects, schizotypical traits, specifically withdrawn aspects of schizotypy, appeared to be related to poorer sensory gating. This findings may support the view that poor P50 sensory gating in schizophrenia is related to symptomatology.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (11 results)

All Other

All Publications (11 results)

  • [Publications] Garcia-Rill E, Skinner RD, Miyazato H: "Pedunculopontine stimulation induces prolonged activation of pontine"Neuroscience. 104(2). 455-465 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Skinner RD, Miyazato H, et al.: "The sleep state-dependent P50 auditory evoked potential in neuro-"International Congress Series. 1232. 813-825 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 宮里 洋, 王 継軍: "ヒトP50中潜時聴性誘発電位のラットモデルP13電位の信頼性"臨床神経生理学. 31(1). 28-36 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Garcia-Rill E, Skinner RD, Miyazato H, Homma Y: "Pedunculopontine stimulation induces prolonged activation of pontine reticular neurons"Neuroscience. 104 (2). 455-465 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Skinner RD, Miyazato H, Garcia-Rill E: "The sleep state-dependent P50 auditory evoked potential in neuropsychiatric diseases"International Congress Series. 1232. 813-825 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Miyazato H, Wang J, Hiramatsu K, Ogura C.: "The human P50 midlatency auditory evoked potential and its animal equivalent -test-retest reliability of the rat P13 potential- (in Japanese)"Japanese Journal of Clinical Neurophysiology. 31 (1). 28-36 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Garcia-Rill E, Skinner RD, Miyazato H: "Pedunculopontine stimulation induces prolonged activation of pontine-"Neuroscience. 104(2). 455-465 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Skinner RD, Miyazato H, et al.: "The sleep state-dependent P50 auditory evoked potential in neuro-"International Congress Series. 1232. 813-825 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 宮里 洋, 王 継軍: "ヒトP50中潜時聴性誘発電位のラットモデルP13電位の信頼性"臨床神経生理学. 31(1). 28-36 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] 宮里洋, 小椋力: "精神分裂病と電圧筋無力症の合併-自験例および文献的考察-"精神神経学雑誌. 103. 842-843 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 宮里洋, 坂根正規 他: "視床血管性病変に伴う痴呆の2症例"九州神経精神医学. 47. 72-73 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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