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Relationship between psychological and occupational stress and cancer risk due to oxidative DNA damage

Research Project

Project/Area Number 13671040
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionAichi Medical University

Principal Investigator

IRIE Masahiro  Aichi Medical University, School of Medicine, Associate Professor, 医学部, 助教授 (00248593)

Co-Investigator(Kenkyū-buntansha) KASAI Hiroshi  University of Occupational and Environmental Health, Institute of Industrial Health Sciences, Professor, 産業生態科学研究所, 教授 (40152615)
KOBAYASHI Fumio  Aichi Medical University, School of Medicine, Professor, 医学部, 教授 (80135342)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2002: ¥700,000 (Direct Cost: ¥700,000)
KeywordsPsychological stress / Occupational stress / Depression / Lifestyle / Oxidative DNA damage / 8-hydroxydeoxyguanosine / Cancer
Research Abstract

Although numerous studies have been carried out on the stress-cancer linkage, the results still inconclusive. One of the useful, but rarely applied, method to assess this linkage is to examine the relationship between psychological stress and cancer prone genetic alterations simultaneously. We investigated whether various psychological factors can be associated with the levels of 8-hydroxydeoxyguanosine (8-OH-dG), a biomarker of cancer-related oxidative DNA damage, in peripheral blood leukocytes in 156 healthy workers (116 males and 40 females). We also examined the mechanism of psychological stress-associated production of 8-OH-dG through the activation of neutrophils and the production of reactive oxygen species from the neutrophils. In addition, we compared the 8-OH-dG levels between depressive patients and healthy age- and sex-matched controls, and analyzed the factors relevant to the 8-OH-dG levels. The levels of 8-OH-dG in female workers were positively correlated with the depression scores of the General Health Questionnaire (GHQ), and negatively associated with the social dysfunction scores of the GHQ. On the other hand, the levels of 8-OH-dG in male workers were positively correlated with the depression scores of the Center for Epidemiologic Studies Depression Scale. No significant relationship was found between the number of peripheral neutrophils and the 8-OH-dG levels. The levels of 8-OH-dG in patients with depression were significantly higher than those in healthy controls; however, no factors were found to be associated with the 8-OH-dG levels in the depressive and control subjects. These findings not only provide evidence of a stress-cancer linkage, but also suggest possible sex differences in the mechanisms of stress-related cancer initiation.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] Irie M.: "Relationships between perceived workload, stress and oxidative DNA damage"International Archives of Occupational and Environmental Health. 74. 153-157 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Irie M.: "Psychosocial factors as a potential trigger of oxidative DNA damage in human leukocytes"Japanese Journal of Cancer Research. 92. 367-375 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Irie M.: "Psychological mediation of a type of oxidative DNA damage, 8-hydroxydeoxyguanosine, in peripheral blood leukocytes of non-smoking and non-drinking workers"Psychotherapy and Psychosomatics. 71. 90-96 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Irie M., Asami S., Nagata S., Miyata M., Kasai H.: "Relationships between perceived workload, stress and oxidative DNA damage"International Archives of Occupational and Environmental Health. 74 (2). 153-157 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Irie M., Asami S., Nagata S., Ikeda M., Miyata M., Kasai H.: "Psychological factors as a potential trigger of oxidative DNA damage in human leukocytes"Japanese Journal of Cancer Research. 92 (3). 367-375 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Irie M., Asami S., Nagata S., Miyata M., Kasai H.: "Psychological mediation of a type of oxidative DNA damage, 8-hydrodeoxyguanosine, in peripheral blood leukocytes of non-smoking and non-drinking workers"Psychotherapy and Psychosomatics. 71 (2). 90-96 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary

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Published: 2002-04-01   Modified: 2016-04-21  

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