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The role of VEGF in nephrons of progressive renal diseases

Research Project

Project/Area Number 13671120
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Kidney internal medicine
Research InstitutionKumamoto University

Principal Investigator

KITAMOTO Yasunori  Kumamoto Univ School of Med, the 3^<rd> Dept of Int Med, Associate professor, 医学部, 講師 (80195297)

Co-Investigator(Kenkyū-buntansha) TOMITA Kimio  Kumamoto Univ School of Med, the 3^<rd> Dept of Int Med, Professor, 医学部, 教授 (40114772)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2002: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 2001: ¥1,800,000 (Direct Cost: ¥1,800,000)
KeywordsVEGF / glomerular protection / vascular endothelial cells / 慢性腎不全 / 糸球体濾過値 / 進行性腎不全 / 糸球体濾過率
Research Abstract

Vascular endothelial growth factor (VEGF) mediates a glomerular development, maintains glomerular endothelial cells and accelerates a repair of injured renal vessels. Recently, protective effect of VEGF for various cell types, including neurons and hepatocytes, is reported. This effect may be independent on angiogenic activity of VEGF. We hypothesize that VEGF may protect glomerular endothelial cells against injuries and tested this hypothesis by evaluating the effect of pre-administered VEGF on the injuries. Mesangial proliferative glomerulonephritis was induced in rats by injecting limited dose of antibody to Thy-1.1 at day 0. At day 1, lysis of mesangium was observed and endothelial cells were ruptured. Capillaries were fused and dilated but endothelial apoptosis was not observed. Recombinant VEGF_<165> was administered to rats at 4 h before injecting the antibody. By this treatment, the endothelial injury at day 1 was significantly suppressed. The protective effect at day 1 was also given by VEGF_<121>. Mechanism of protection was unrelated to apoptosis. This protection may have therapeutic potential against glomerular injuries in progressive renal disease.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (5 results)

All Other

All Publications (5 results)

  • [Publications] Kitamoto Y et al.: "Glomerular endothelial cells are maintained by vascular endothelial growth factor in the adult kidney"Tohoku J Exp Med. 195. 43-54 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Maeda H et al.: "Vascular permeability enhancement in solid tumor : various factors, mechanisms involved and its implications"International Immunopharmacology. 3. 319-328 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Miyamoto et al.: "VEGF121 and VEGF165 protect glomerular endothelial cells and accelerate a remodeling of injured glomeruli"J Exp Med. (submitted).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Maeda H, Fang J, Inutsuka T, Katamoto Y: "Vascular permeability enhancement in solid tumor : various factors, mechanisms involved and its implication"International Immunopharmacology. (印刷中). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kitamoto Y: "Glomerular endothelial cells are maintained by vascular endothelial growth factor in the adult kidney"Tohoku J Exp Med. 195(1). 43-54 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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