| Project/Area Number |
13671159
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
TAKASU Nobuyuki University of the Ryukyus, Department of Medicine, Professor, 医学部, 教授 (20020927)
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| Co-Investigator(Kenkyū-buntansha) |
KOUKI Tuyoshi University of the Ryukyus, Department of Medicine, Instructor, 医学部附属病院, 助手 (80273415)
SHIMABUKURO Michio University of the Ryukyus, Department of Medicine, Assistant Professor, 医学部附属病院, 講師 (60271144)
小宮 一郎 琉球大学, 医学部, 助教授 (50162061)
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| Project Period (FY) |
2001 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2002: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2001: ¥2,100,000 (Direct Cost: ¥2,100,000)
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| Keywords | Graves' disease / Hyperthyroidism / Remission / CTLA-4 / TSAb (thyroid stimulating Ab) / TRAb (TSH receptor Ab) / CTLA-4遺伝子多型 / 放射線療法 / 遺伝子異常 / 高感度TSAb / CTLA-4遺伝子多形 |
|---|
| Research Abstract |
We studied whether a patient with Graves' disease will go into remission during antithyroid drug (ATD) treatment. Remission of Graves' hyperthyroidism is predicted by a smooth decrease in TSH receptor antibody (TRAb) during ATD treatment. Cytotoxic T cell lymphocyte-associated molecule-4 (CTLA-4) may play an important role in the development of Graves' hyperthyroidism and in its remission. We studied A/G polymorphism at position 49 in exon 1 of the CTLA-gene in Japanese Graves' patients. We revealed the association of CTLA-4 polymorphism with remission of Graves' hyperthyroidism.
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