| Project/Area Number |
13671161
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Endocrinology
|
|---|
| Research Institution | Saitama Medical School |
|---|
Principal Investigator |
KAWAZU Shoji Saitama Medical School, medicine, Professor, 医学部, 教授 (30134547)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KOMEDA Kjuro Tokyo Medical Univercity, medicine, Professor, 医学部, 教授 (90074533)
OMURA Eiji Saitama Medical School, medicine, Lecturer, 医学部, 講師 (90119917)
|
|---|
| Project Period (FY) |
2001 – 2002
|
| Project Status |
Completed (Fiscal Year 2002)
|
| Budget Amount *help |
¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2002: ¥1,100,000 (Direct Cost: ¥1,100,000)
|
|---|
| Keywords | Mutant / Mapping / Rat / Dwarfism / 低身長(dwarf) |
|---|
| Research Abstract |
A novel autosomal recessive dwarf mutation, miniature rat Ishikawa (mri), was discovered in, a closed colony of Wistar rats. The mutant strain has recently been established as a segregating inbred, named Miniature Rat Ishikawa (MRI). In the present study, we characterized the phenotype of MRI and also performed genetic analyses of the mutation. The homozygous mutants (mri/mri) grew retarded among 60 to 70% of normal sized littermates. Their longitudinal growth was especially impaired. Genetic analyses placed the mri locus in a genomic segment of 1.2cM on rat chromosome 14. Comparative mapping suggested that the orthologs of mri are located on mouse chromosome 5 and human chromosome 4p14-q21. These data suggest that the mri mutation may be a novel dwarf mutation and that MRI should serve as a useful animal model for dwarfism in humans.
|
