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Cerebral endothelial cell and Neurotrophins

Research Project

Project/Area Number 13671177
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Metabolomics
Research InstitutionCHIBA UNIVERSITY

Principal Investigator

TATSUNO Ichiro  Chiba University, Graduate School of Medicine, Lecturer, 大学院・医学研究院, 講師 (80282490)

Co-Investigator(Kenkyū-buntansha) SAEKI Naokatsu  Chiba University, Graduate School of Medicine, Associate Professor, 大学院・医学研究院, 助教授 (30143275)
UCHIDA Daigaku  Chiba University, University Hospital, Assistant, 医学部附属病院, 助手 (80323426)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 2002: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2001: ¥1,400,000 (Direct Cost: ¥1,400,000)
KeywordsCerebral Endothelial cell / Oxidozed LDL / Neurotrophin / Neurotrophin Receptor / Proliferation / NO / PACAP / Cross-talk
Research Abstract

Cerebral endothelial cells (CEC) are one of the major and key components for formation of the vascular system in the mammalian central nervous system (CNS), which is characteristic and different from that in other organs in terms of the formation of the blood-brain barrier (BBB). Although it has been clarified that both formation and maintenance of the vascular system in CNS are dependent on the cross-talk between neuronal cells and vascular endothelial cells, the precise mechanism is still being investigated. In this regard, we focused on the neurotrophin (NT) produced by neuronal cells for its possible involvement in signaling for the regulation of CEC in comparison of rat cerebral endothelial cells (RCEC) with rat aortic endothelial cells (RAEC). We found that 1) trk C, a receptor for neurotrophin-3 (NT-3), is dominantly expressed in RCEC, but trk B, a receptor for brain-derived neurotrophic factor (BDNF), is dominantly expressed in RAEC ; 2) NT-3 inhibited the proliferation of RCEC ; and 3) NT-3 stimulated the production of nitric oxide (NO) with increases in protein expression of endothelial NO synthase (eNOS). These data indicated that NT may regulate and/or maintain the functions of the brain microvasculature through the regulation of CEC.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (19 results)

All Other

All Publications (19 results)

  • [Publications] Ichiro Tatsuno: "Anticonvulsant hypersensitivity syndrome with marked eosinophilia in treatment of diabetic neuropathy"Diabetes Care. 25. 1099-1100 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Naokatsu Saeki: "Correlation of high signal of the pituitary stalk In macroadenoma and postoperative diabetes inspidus"Am J Neuroradiol. 23. 822-827 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ichiro Tatsuno: "Anterior ischemic optic neuropathy associated with idiopathic aldosteronism and hypertension"Opthalmologia. 216. 68-70 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ichiro Tatsuno: "Maxadilan specifically interacts with PAC1 receptor, which is a dominant form of PACAP/VIP family receptors in cultured rat cortical neurons"Brain Res. 889. 138-148 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ichiro Tatsuno: "PACAP is an anti-mitogenic signal in developing cerebral cortex"Nature Neuroscience. 4. 123-124 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yamada N, Kaneko K, Saito Y, Tatsuno I: "Anticonvulsant hypersensitivity syndrome with marked eosinophilia in treatment of diabetic neuropathy"Diabetes Care. 25. 1099-1100 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Saeki N, Hoshi S, Sunada S, Sunami K, Murai H, Kubota M, Tatsuno I, Iuchi T, Yamaura A: "Correlation of high signal of the pituitary stalk In macroadenoma and postoperative diabetes inspidus"Am J Neuroradiol. 23. 822-827 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Taniai M, Mizota A, Adachi-Usami E, Tatsuno I: "Anterior ischemic optic neuropathy associated with idiopathic aldosteronism and hypertension"Opthalmologia. 216. 68-70 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Saito J, Kohn AD, Roth RA, Noguchi Y, Tatsuno I, Hirai A, Suzuki K, Kohn LD, Saji M, Ringel MD: "Regulation of FRTL-5 thyroid cell growth by phosphatidylinositol (OH) 3 kinase-dependent Akt-mediated signaling"Thyroid. 11. 339-351 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sakashita Y, Kurihara T, Uchida D, Tatsuno I, Yamamoto T: "Involvement of PACAP receptor in primary afferent fiber-evoked responses of ventral roots in the neonatal rat spinal cord"Br J Pharmacol. 132. 1769-1776 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Saeki N, Nagano O, Sakaida T, Murai H, Kubota M, Yamaura H, Kitou H, Tatsuno I.: "Recurrent neurohypophyseal germinoma causing invasion localized to temporal bone marrow-unreported neuroimaging studies compared to autopsy findings"Acta Neurochirurgica. 143. 407-411 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Suh J, Lu N, Nicot A, Tatsuno I, DiCicco-Bloom E: "PACAP is an anti-mitogenic signal in developing cerebral cortex"Nature Neuroscience. 4. 123-124 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tatsuno I, Uchida D, Tanaka T, Hirai A, Saito Y, Moro O, and Tajima M: "Maxadilan specifically interacts with PAC1 receptor, which is a dominant form of PACAP/VIP family receptors in cultured rat cortical neurons"Brain Res. 889. 138-148 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ichiro Tatsuno: "Anticonvulsant hypersensitivity syndrome with marked eosinophilia in treatment of diabetic neuropathy"Diabetes Care. 25. 1099-1100 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Naokatsu Saeki: "Correlation of high signal of the pituitary stalk In macroadenoma and postoperative diabetes inspidus"Am J Neuroradiol. 23. 822-827 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ichiro Tatsuno: "Anterior ischemic optic neuropathy associated with idiopathic aldosteronism and hypertension"Opthalmologia. 216. 68-70 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ichiro Tatsuno: "Maxadilan specifically interacts with PAC1 receptor, which is a dominant form of PACAP/VIP family receptors in cultured rat cortical neurons"Brain Res. 889. 138-148 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Ichiro Tatsuno: "PACAP is an anti-mitogenic signal in developing cerebral cortex"Nature Neuroscience. 4. 123-124 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Daigaku Uchida: "Involvement of PACAP receptor in primary afferent fibre-evoked responses of ventral roots in the neonatal rat spinal cord"Br J Pharmacol.. 132. 1769-1776 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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