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Comparative analysis of intraductal spread of breast cancer between helical computed tomography and magnetic resonance imaging.

Research Project

Project/Area Number 13671212
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionTOHOKU University

Principal Investigator

ISHIDA Takanori  Tohoku Univ, Hospital, Research Associate, 医学部附属病院, 助手 (70323011)

Co-Investigator(Kenkyū-buntansha) OHUCHI Noriaki  Tohoku Univ. Graduate School of Medicine, Professor, 大学院・医学系研究科, 教授 (90203710)
MORIYA Takuya  Tohoku Univ. Hospital, Associate Professor, 医学部附属病院, 助教授 (00230160)
ISHIBASHI Tadashi  Tohoku Univ. Graduate School of Medicine, Associate Professor, 大学院・医学系研究科, 助教授 (40151401)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2002: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2001: ¥2,600,000 (Direct Cost: ¥2,600,000)
KeywordsBreast Cancer / Breast Conserving Surgery / 3-D Helical CT / helical CT / MRI / Intraductal Spread of Carcinoma / Multicentricity / 三次元画像 / ヘリカルCT
Research Abstract

BACKGROUND. Surgical clearance of all the cells is important to avoid local failure in breast conserving surgery. Various imaging modalities have been applied to predict the carcinoma extension. We have reported that 3-D magnetic resonance imaging (MRI) is more accurate than mammography and ultrasonography in measuring the extent of tumor when precisely assessed with histological measurements. This study was initiated to compare the utility of helical computed tomography (CT) and 3-D MRI in detecting the extension and multicentricity of breast cancer.
METHODS. Fifty-two patients with primary breast cancer were subjected to helical CT and MRI, subsequently reconstructed three dimensionally using software before operation. Surgical specimens were subjected to serial slices 5mm thick and mapped pathologically. The sensitivity, specificity and accuracy were investigated for detecting intraductal spread of carcinoma (ISC) and multicentricity of small foci of breast cancer.
RESULTS. 1) Seventeen cases with high grade ISC (over 2cm) were observed pathologically. Both CT and MRI were useful for detecting high grade ISC in 11 of 17 cases, whereas neither of them were available in 5 of 17 cases. 2) The sensitivity of MRI for detecting high grade ISC was higher than CT (71% vs 65%). 3) The specificity of CT for detecting multicentricity was higher than MRI (93% VS 80%). 4) Both CT and MRI were more accurate in measuring carcinoma extension when tumor with comedo type of intraductal component and high histological grade (grade III).
CONCLUSIONS. The results suggested that 3-D CT tends to underestimate, whereas 3-D MRI is likely to overestimate. Subtype of intraductal component and histological grade were associated with accuracy of measuring carciooma extension due to high vascularity

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] Yasuhiro Tamaki, Sadako Akashi-Tanaka, Takanori Ishida et al.: "3-D imaging of intraductal spread of breast cancer and its clinical application for navigation surgery"Breast Cancer. 9. 289-295 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 石田 孝宣, 大内 憲明: "乳癌手術療法(温存療法)の完成度"臨床外科. 57.3. 283-288 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 石田 孝宣, 大貫 幸二 他: "乳癌に対する乳房扇状部分切除術"臨床外科. 56.11. 348-354 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yasuhiro Tamaki, Sadako Akashi-Tanaka, Takanori Ishida: "3-D imaging of intraductal spread of breast cancer and its clinical application for navigation surgery."Breast Cancer. 9. 289-295 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takanori Ishida, Noriaki Ohuchi: "The consummation of breast conserving therapy for breast cancer patient."Journal of Clinical Surgery. 57(3). 283-288 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takanori Ishida, Koji Onuki, Takuya Mori. Tadashi Ishibashi, Noriaki Ohuchi: "Qwadrantectomy for breast cancer."Journal of Clinical Surgery. 56(11). 348-354 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 石田 孝宣: "乳癌手術療法(温存療法)の完成度"臨床外科. 57.3. 283-288 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yasuhiro Tamaki, Sadako Akashi-Tanaka, Takanori Ishida et al.: "3-D imaging of intraductal spread of breast cancer and its clinical application for navigation surgery"Breast Cancer. 9.4. 289-295 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 石田 孝宣: "乳癌に対する乳房扇状部分切除術"臨床外科. 56.11. 348-354 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 石田 孝宣: "乳癌手術療法(温存療法)の完成度"臨床外科. in print. (2002)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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