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Investigation for the specific cancer immunotherapy using antigens recognized by a human natural antibody and the anti-idiotypic antibodies

Research Project

Project/Area Number 13671215
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionCHIBA UNIVERSITY

Principal Investigator

KODA Keiji  Chiba University, Graduate School of Medicine, Lecturer, 大学院・医学研究院, 講師 (50260477)

Co-Investigator(Kenkyū-buntansha) ODA Kenji  Chiba University, Graduate School of Medicine, Assistant, 大学院・医学研究院, 助手 (90282483)
滝口 伸浩  千葉大学, 大学院・医学研究院, 助手 (00261917)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2002: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 2001: ¥1,800,000 (Direct Cost: ¥1,800,000)
Keywordshuman monoclonal antibody / SK1 / cancer immunotherapy / anti-idiotypic antibody / colon cancer / breast cancer / 特異的癌免疫治療 / ペプチドワクチン / AgSK1
Research Abstract

SK1 is an IgM human monoclonal antibody which recognizes a widely expressed glycoprotein antigen found on adenocarcinoma tissues. The antigen recognized by SK-1 (AgSK1) has a molecular weight of 42-46 kilodaltons and is strongly expressed on cells with high invasion capacity. We have recently identified a peptide sequence that is recognized by SK1. The antigen consisted of 54 amino acids and carboxyl terminal 20 amino acids were the antigenic epitope of SK1. The RT-PCR to determine the quantity of the AgSK1 in the panel of the human tissues revealed that the quantity of the mRNA level which encoded the AgSK1 was high in colon cancer cell lines and tissues. Whereas there was quite low or even no amount of the mRNA level found in non-epithelial tumor cell lines or in the normal colon mucosa, blood of no-cancer-bearing cases. These findings were consistent with the AgSK1 protein level in several tissues and cell lines determined by immunohistochemistry or Western blotting. We are now constructing a fibroblast cell line that had originally no AgSK1 detected but have expressed high level of AgSK1 by gene transduction. The invasion or motility capacity of the fibroblast and the inhibitory effect of this cell line by SK1 is now under investigation.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (18 results)

All Other

All Publications (18 results)

  • [Publications] Keiji Koda, et al.: "Immunotherapy for recurrent colorectal cancers with human monoclonal antibody SK1"Anticancer Research. 21. 621-628 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] M Glassy, K Koda: "The nature of an ideal therapeutic human antibody"Expert opin Biol Ther. 2(1). 1-2 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 幸田圭史, 他: "大腸癌に対するモノクローナル抗体を用いた診断と治療の現況"日本臨床. 60(3). 539-544 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Keiji Koda, et al.: "Natural killer cell activity and distant metastasis in rectal cancers treated surgically with/without neoadjuvant chemoradiotherapy"J Am Col Surg. (In press). (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kondo E, Koda K, et al.: "Preoperative natural killer cell activity as a prognostic factor for distant metastasis following surgery for advanced colon cancer"Digestive Surg. (In press). (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Keiji Koda, Norio Saito, Kenji Oda, Kazuhiro Seike, Eisuke Kondo, Mitsuru Ishizuka, Nobuhiro Takiguchi, Masaru Miyazaki: "Natural killer cell activity and distant metastasis in rectal cancers treated surgically with/without neoadjuvant chemo-radiotherapy"J Am Col Surg. in press. (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Glassy M, and Koda K: "The nature of an ideal therapeutic human antibody"Expert Opin. Biol. Ther.. 2(1). 1-2 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Keiji Koda, Mark C. Glassy, Michael E. McKnight, Jun Yasutomi, Norio Saito, Michael Dan, and Nobuyuki Nakajima: "Immunotherapy for recurrent colorectal cancers with human monoclonal antibody SK-1"Anticancer Res.. 21(1B). 621-627 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Koda K, Miyazaki M: "Clinical assessment of monoclonal antibodies for the treatment and diagnosis of colorectal cancers"Nippon Rinsho. 60(3). 539-544 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kondo E, Koda K, Takiguchi N, Oda K, Seike K, Ishizuka M, Miyazaki M: "Preoperative natural killer cell activity as a prognostic factor for distant metastasis following surgery for colon cancer"Digest Surg.. in press. (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Keiji Koda, et al.: "Immunotherapy for recurrent colorectal cancers with human monoclonal antibody SK1"Anticancer Research. 21. 621-628 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] M Glassy, K Koda: "The nature of an ideal therapeutic human antibody"Expert opin Biol Ther. 2(1). 1-2 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 幸田圭史, 他: "大腸癌に対するモノクローナル抗体を用いた診断と治療の現況"日本臨床. 60(3). 539-544 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Keiji Koda, et al.: "Natural killer cell activity and distant metastasis in rectal cancers treated surgically with/without neoadjuvant chemo-radiotherapy"J Am Col Surg. (In press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kondo E, Koda K, et al.: "Preoperative natural killer cell activity as a prognostic factor for distant metastasis following surgery for advanced colon cancer"Digestive Surg. (In press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Glassy M, Koda K: "The nature of an ideal therapeutic human antibody"Expert. Opin. Biol. Ther.. 2(1). 1-2 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Keiji Koda: "Immunotherapy for recurvent cdorectal cancers with human monoclonal antibody SK1"Anticancer Res. 21(1B). 621-627 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 幸田圭史: "大腸癌に対するモノクローナル抗体を用いた診断と治療の現況"日本臨床. 60(3). 539-544 (2002)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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