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DEVELOPMENT OF CYTOKINE ADSORPTION COLUMN AND THE TREATMENT OF MULTIPLE ORGAN FAILURE BY CYTOKINE ADSORPTION COLUMN

Research Project

Project/Area Number 13671216
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionCHIBA UNIVERSITY

Principal Investigator

ODA Shigeto  CHIBA UNIVERSITY, GRADUATE SCHOOL OF MEDICINE, ASSOCIATE PROFESSOR, 大学院・医学研究院, 助教授 (90204205)

Co-Investigator(Kenkyū-buntansha) MATSUDA Kenichi  CHIBA UNIVERSITY, UNIVERSITY HOSPITAL, LECTURER, 医学部附属病院, 講師 (60282480)
SHIGA Hidetoshi  CHIBA UNIVERSITY, UNIVERSITY HOSPITAL, LECTURER, 医学部附属病院, 講師 (20282478)
HIRASAWA Hiroyuki  CHIBA UNIVERSITY, GRADUATE SCHOOL OF MEDICINE, PROFESSOR, 大学院・医学研究院, 教授 (80114320)
NAKAMURA Masataka  CHIBA UNIVERSITY, UNIVERSITY HOSPITAL, ASSISTANT, 医学部附属病院, 助手 (30315436)
中西 加寿也  千葉大学, 医学部附属病院, 講師 (80272326)
Project Period (FY) 2001 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2003: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2002: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2001: ¥1,900,000 (Direct Cost: ¥1,900,000)
Keywordscytokine / selective adsorption / multiple organ failure / MPC-FX / T-SAAF / 敗血症性ショック / 全身性炎症反応症候群 / 選択的吸着剤 / 免疫吸着
Research Abstract

Cytokines plays an important role in the pathophysiology of multiple organ failure (MOF). This study was undertaken to develop a cytokine adsorption column, which selectively removes cytokines from blood stream, and to establish a new therapeutic modality for the treatment of MOF. Various adsorbents, which are already clinically applied as immunoadsorption columns for the treatment of various diseases or under development were investigated on their cytokine adsorptive property for development of a new cytokine adsorption column. Among tested adsorbents, Lixelle β2-adsorbing column for dialysis related amyloidosis) and CF-X (developing as an immunoadsorption column for autoimmune diseases) have been. revealed to have high affinity to various cytokines and these adsorbents were selected for the development of a cytokine adsorption column. Although CF-X had the highest affinity to TNF-α, it also adsorbed normal γ-globulin. Therefore, a new MPC coated adsorbent (MPC-FX) was developed. MPC-FX could effectively adsorb various cytokines without adsorbing normal Ig G. However, the development of MPC-FX column abandoned because of circumstances of company. A new adsorbent T-SAAF, which was developed to adsorb super antigen of gram positive bacteria, was tested. T-SAAF has been revealed to adsorb various cytokines in vitro study. T-SAAF has been evaluated its safety and efficacy in animal models. Clinical trials would be started near future. In a clinical study, indication of cytokine adsorption columns was studied with rapid measurement system of blood IL-6. Patients with IL-6 blood levels >10,000pg/mL were difficult to control hypercytokinemia even with PMMA-CHDF and had poor prognosis. It was confirmed that genetic polymorphisms in cytokine related genes were related to hypercytokinemia among these patients. These patients. would be good candidates for the application of a cytokine adsorption column.

Report

(4 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] Matsuda K, Hirasawa H, Oda S, Shiga H, Nakanishi K: "Current topics on cytokine removal technologies"Therapeutic Apheresis. 5. 306-314 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 松田兼一, 平澤博之, 織田成人.志賀英敏, 中西加寿也, 仲村将高: "Cytokine血中濃度迅速測定"救急医学. 25. 847-853 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 織田成人, 平澤博之, 松田兼一: "サイトカイン除去技術の最近の動向"日本アフェレシス学会雑誌. 21. 47-53 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Oda S, Hirasawa H, Shiga H, Nakanishi K, Matsuda K, Nakamura M: "Continuous hemofilitration/hemodiafiltration in critical care"Therapeutic Apheresis. 6. 193-198 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 織田成人, 平澤博之, 志賀英敏, 中西加寿也, 松田兼一, 仲村将高: "腹部救急疾患に合併した敗血症性ショックに対する治療戦略"日本腹部救急医学会雑誌. 22. 791-799 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 織田成人, 平澤博之, 志賀英敏, 松田兼一, 上野博一, 仲村将高, 渡遅栄三: "重症感染症の病態とメディエーター"日本外科学会雑誌. 104. 511-517 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 松田兼一, 平澤博之, 織田成人, 志賀英敏, 中西加寿也, 仲村将高: "Hypercytokinemiaおよびcytokine factoryの診断とその対策"ICUとCCU. 27. 37-48 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 渡邊栄三, 平澤博之, 織田成人, 松田兼一, 徳久剛史, 幡野雅彦: "Cytokine産生に関する遺伝子多型"ICUとCCU. 27. 3-10 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 織田成人, 平澤博之, 松田兼一: "抗サイトカイン療法"Medical Practice. 20(suppl). 68-71 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 織田成人, 平澤博之, 新田正和: "重症感染症の集学的治療"消化器外科. 26. 1231-1239 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Matsuda K, Hirasawa H, Oda S, Shiga H, Nakanishi K: "Current topics on cytokine removal technologies"Therapeutic Apheresis. 5. 306-314 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Oda S, Hirasawa H, Matsuda K: "Recent progress in technique for cytokine removal with blood purification"Japanese Journal of Apheresis. 21. 47-53 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Oda S, Hirasawa H, Shiga H, Nakanishi K, Matsuda K, Nakamura. M: "Continuous hemofiltration/hemodiafiltration in critical care"Therapeutic Apheresis. 6. 193-198 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Oda S, Hirasawa H, Shiga H, Nakanishi K, Matsuda K, Nakamura M: "Therapeutic strategy for patients with septic shock complicated abdominal emergency"Journal of Abdominal Emergency Medicine. 22. 791-799 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Oda S, Hirasawa H, Shiga H, Matsuda K, Ueno H, Nakamura. M, Watanabe E: "Humoral mediators in the pathophysiology of organ dysfunction in sepsis"Journal of Japan Surgical Society. 104. 511-517 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 織田成人, 平澤博之, 志賀英敏, 松田兼一, 上野博一, 仲村将高, 渡邉栄三: "重症感染症の病態とメディエーター"日本外科学会雑誌. 104. 511-517 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 松田兼一, 平澤博之, 織田成人, 志賀英敏, 中西加寿也, 仲村将高: "Hypercytokinemiaおよびcytokine factoryの診断とその対策"ICUとCCU. 27. 37-48 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 渡邉栄三, 平澤博之, 織田成人, 松田兼一, 徳久剛史, 幡野雅彦: "Cytokine産生に関する遺伝子多型"ICUとCCU. 27. 3-10 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 織田成人, 平澤博之, 松田兼一: "抗サイトカイン療法"Medical Practice. 20(suppl). 68-71 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 織田成人, 平澤博之, 新田正和: "重症感染症の集学的治療"消化器外科. 26. 1231-1239 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Shigeto Oda et al.: "Continuous hemofiltration/hemodiafiltration in critical care Therapeutic Apheresis"Therapeutic Apheresis. 6・3. 193-198 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 織田成人 他: "腹部救急疾患に合併した敗血症性ショックに対する治療戦略"日本腹部救急医学会雑誌. 22・5. 791-799 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kenichi Matsuda, et al.: "Current topics in cytokine removal technologies"Therapeutic Apheresis. 5・4. 306-314 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 織田 成人 他: "サイトカイン除去技術の最近の動向"日本アフェレシス学会雑誌. 21・1. 47-53 (2002)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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