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The development of blood glucose control system for perioperative period or severely diabetic patients based on a new control theory

Research Project

Project/Area Number 13671228
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionKyoto University

Principal Investigator

ONODERA Hisashi  Kyoto University, Graduate School of Medicine, Associate Professor, 医学研究科, 助教授 (50240825)

Co-Investigator(Kenkyū-buntansha) IMAMURA Masayuki  Kyoto University, Graduate School of Medicine, Professor, 医学研究科, 教授 (00108995)
YAMASAKI Seiji  Kyoto University, Graduate School of Medicine, Instructor, 医学研究科, 助手 (50303839)
FURUTANI Eiko  Kyoto University, Graduate School of Engineering, Associate Professor, 工学研究科, 助教授 (40219118)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2002: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2001: ¥2,600,000 (Direct Cost: ¥2,600,000)
Keywordsblood glucose control system / Model predictive controller / state predictive controller / gain scheduling method / artificial pancreas / Diabetes Mellitus
Research Abstract

We developed a novel blood glucose control system using a model predictive method, in order to achieve optimal control of the blood glucose level in severely diabetic or pancreatectomized patients. This system is designed to predict glucose level changes in advance, considering delayed response time and the administered doses of insulin. This method is also designed to calculate the most appropriate insulin infusion rate by considering differences in individual response to insulin.In the first experiment, we compared our system with a conventional proportional and differential controller (PD controller) in order to determine whether the new system could regulate the glucose level efficiently in pancreatectomized dogs. The model predictive control method resulted in a significant reduction of mean insulin infusion rate compared to the conventional PD controller, when the glucose level in both methods reached the planned target level (100mg/dl). The new system also tended to have a reduc … More ed mean glucose infusion rate for compensating the overshooting of the glucose level compared to the PD controller. We have then made a further experiment to control the blood glucose under continuous glucose infusion in pancreatomized dogs employing either the conventional PD controller or the model control method, considering the environment where the patients are kept under continuous intravenous glucose infusion after surgery. However, contrary to our expectation, it was also observed that the model predictive controller failed to control the blood glucose level stably under glucose infusion at a high rate, although it was effectively controlled when the pancreatectomized dogs were not under glucose infusion or were under glucose infusion at a low rate. With the aim of controlling blood glucose under continuous glucose infusion, we thus improved the system by integration of the proportional controller and the model predictive controller. Addition of the modified proportional controller to the model predictive controller can stabilize the blood glucose control even under continuous glucose infusion. This system is a potentially effective method for the management of severely diabetic patients and pancreatectomized patients during and after surgery Less

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] Shugen Kan et al.: "How to control blood glucose under continuous glucose challenge"ASAIO Journal. (In Press). (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 市川洋光ほか: "血糖値制御システムのオンラインゲインスケジューリング"第45回システム制御情報学会論文集. 277-278 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 橋本 正ほか: "状態予測制御法を用いたオンライン調製機能付き血糖制御システム"第47回システム制御情報学会論文集. 551-552 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 市川洋光ほか: "血糖制御システムにおける制御対象モデルの検討"第47回システム制御情報学会論文集. 553-554 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Shugen Kan, Hisashi Onodera, Satoshi. Nagayama, Eiko Furutani, Mituhiko Araki and Masayuki lmamura: "How to control blood glucose under continuous glucose challenge"ASAIO Journal. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ichikawa H, Higuchi S, Furutani E, Kan S, Onodera H, Araki M and Masayuki Imamura: "Blood glucose control system using gain scheduling"Proceeding of the 45^<th> annual conference of the Institute of Systems, Control and Information Engineers. 277-278 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hashimoto T, Furutani E, Onodera H, Araki M and Masayuki Imamura: "Blood glucose system using astate predictive controller with an auto-tuning function"Proceeding of the 47^<th> annual conference of the Institute of Systems, Control and Information Engineers. 551-552 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ichikawa H, Murai T, Hashimoto T, Furutani E, Onodera H, Araki M and Masayuki Imamura: "A study of a plant model for blood glucose control"Proceeding of the 47^<th> annual conference of the Institute of Systems, Control and Information Engjneers. 553-554 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Shugen Kan, et al.: "How to control blood glucose under continuous glucose challenge"ASAIO Journal. (in press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] 野島尚弘 他: "汎用化を目的とした血圧制御システムの改良"第44回システム制御情報学会論文集. 575-576 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] 市川洋光 他: "血糖値制御システムオンラインゲインスケジューリング"第45回システム制御情報学会論文集. 277-278 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Shugen Kan, Hisashi Onodcra et al.: "A novel control system for blood glucose using a model predictive method"ASAIO Journal. 46. 657-662 (2000)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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