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INDICATION OF BREAST CONSERVATIVE SURGERY FOR PRIMARY BREAST CANCER USING COMPUTER GRAPHIC THREE-DIMENSIONAL RECONSTRUCTION OF THE MAMMARY DUCT-LOBULAR SYSTEMS

Research Project

Project/Area Number 13671246
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionFUKUSHIMA MEDICAL UNIVERSITY

Principal Investigator

TAKENOSHITA Seiichi (2002)  FUKUSHIMA MEDICAL UNIVERSITY, THE SECOND DEPARTMENT OF SURGERY, PROFESSOR, 医学部, 教授 (10167489)

君島 伊造 (2001)  福島県立医科大学, 医学部, 講師 (00161547)

Co-Investigator(Kenkyū-buntansha) 竹之下 誠一  福島県立医科大学, 医学部, 教授 (10167489)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 2002: ¥200,000 (Direct Cost: ¥200,000)
Fiscal Year 2001: ¥3,600,000 (Direct Cost: ¥3,600,000)
KeywordsBreast cancer / Intraductal spread / Computer graphics / Three-dimensional reconstruction / Brest-conserving surgery / Mammary ductal / lobular system / 乳管腺葉系 / 画像解析装置 / 乳房温存療法 / 乳管内進展の病理 / 乳癌の発生と進展
Research Abstract

Intraductal spread of breast cancer can occur along the mammary duct/lobular systems (MDLS) with no invasion of tissues. As ductal anastomoses in the MDLS are considered a possible risk factor for extensive intraductal spread of breast cancer, the architecture of MDLS has important therapeutic implications for patients treated by breast-conserving surgery. An entire breast resected by subcutaneous mastectomy from a 69-year-old woman with ductal carcinoma in situ (DCIS) was examined in subgross sections by stereomicroscopic and histologic techniques. Serial 2-mm sections were subjected to computer-assisted complete three-dimensional reconstruction of all MDLS. The entire breast used contained 16 MDLS, radially arranged with the nipple at the center. Of 16 MDLS, 4 (25.0%) had ductal anastomoses while the remaining 12 MDLS had no ductal anastomoses and completely independent regional anatomy. Ductal anastomoses were observed at 11 sites in the 4 MDLS. The 2 (18.2%) of 11 ductal anastomoses that connected different MDLS were situated more than 4 cm from the nipple. The remaining 9 connected ducts within the same MDLS ; their location varied from near the nipple to the peripheral region. In the case examined, DCIS extended only within a single MDLS, and did not spread between different MDLS via ductal anastomoses. The complete architecture of all MDLS in an entire breast was studied three-dimensionally for the first time to the authors' knowledge. The risk of extending intraductal spread during surgery may be greater where intraductal lesions extend more peripherally than centrally. Individualizing the extent of surgical resection based on the anatomy of MDLS should help to minimize the risk of leaving residual carcinoma at surgical margins.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (27 results)

All Other

All Publications (27 results)

  • [Publications] 大竹 徹他: "コンピューター支援下3次元再構築による乳房内全乳管腺葉系の解剖学的検討"乳癌の臨床. 15(5). 610-611 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ohtake T, et al.: "Three-dimensional reconstruction of the whole breast duct/lobular units"Breast Cancer Research and Treatment. 64(1). 104-104 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ohtake T, et al.: "Giant mammary hamartoma diagnosed by stereomicroscopic analysis of the mammary glandular tree in an adolescent girl"Surgery Today. 31. 433-437 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ohtake T, et al.: "Computer-assisted complete three-dimensional reconstruction of the mammary ductal/lobular systems. Implications of ductal anastomoses for breast-conserving surgery"Cancer. 91. 2263-2272 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Watanabe T, et al.: "Sentinel node biopsy with technetium-99m colloidal rhenium sulphide in patients with breast cancer"Br J Surg. 88. 704-707 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ohtake T, et al.: "Computer Assisted Complete Three-dimensional Reconstruction of Multiple Breast Carcinomas. Pathological Analysis on Discrimination between Multicentric and Multifocal Tumors"Breast Cancer Research and Treatment. (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] OHTAKE T, et al.: "INTRADUCTAL EXTENSION OF PRIMARY INVASIVE BREAST CARCINOMA TREATED BY BREAST-CONSERVATIVE SURGERY"CANCER. 76(1). 32-45 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] RIKIYA A, et al.: "GROWTH OF BREAST CANCER AND LIMITED SURGERY"BREAST CANCER. 3. 1-7 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] TSUCHIYA A, et al.: "PROGNOSTIC RELEVANCE OF TN EXPRESSION IN BREAST CANCER"BREAST CANCER. 6. 175-180 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] KIMIJIMA I, et al.: "SCATTERED FAT INVASION : AN INDICATION FOR POOR PROGNOSIS IN PREMENOPAUSAL AND FOR POSITIVE ESTROGEN RECEPTOR IN POSTMENOPAUSAL BREAST CANCER PATIENTS"ONCOLOGY. 59. 25-30 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] OHTAKE T, et al.: "THREE-DIMENSIONAL RECONSTRUCTION OF THE WHOLE BREAST DUCT/LOBULAR UNITS"BREAST CANCER RESEARCH AND TREATMENT. 64(1). 104 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] OHTAKE T, et al.: "GIANT MAMMARY HAMARTOMA DIAGNOSED BY STEREOMICROSCOPIC ANALYSIS OF THE MAMMARY GLANDULAR TREE IN AN ADOLESCENT GIRL"SURGERY TODAY. 31. 433-437 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] OHTAKE T, et al.: "COMPUTER-ASSISTED COMPLETE THREE-DIMENSIONAL RECONSTRUCTION OF THE MAMMARY DUCTAL/LOBULAR SYSTEMS"CANCER. 91. 2263-2272 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] WATANABE T, et al.: "SENTINELNODE BIOPSY WITH TECHNETIUM-99M COLLOIDAL RHENIUM SULPHIDE IN PATIENTS WITH BREAST CANCER"BRITISH JOURNAL OF SURGERY. 88. 704-707 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] OHTAKE T, et al.: "COMPUTER-ASSISTED COMPLETE THREE-DIMENSIONAL RECONSTRUCTION OF MULTIPLE BREAST CARCINOMAS"BREAST CANCER RESEARCH AND TREATMENT. 64(1). 104 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 大竹 徹, 他: "コンピューター支援下3次元再構築による乳房内全乳管腺葉系の解剖学的検討"乳癌の臨床. 15(5). 610-611 (2000)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ohtake T, et al.: "Three-dimensional reconstruction of the whole breast duct/lobular units"Breast Cancer Research and Treatment. 64(1). 104-104 (2000)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ohtake T, et al.: "Giant mammary hamartoma diagnosed by stereomicroscopic analysis of the mammary glandular tree in an adolescent girl"Surgery Today. 31. 433-437 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ohtake T, et al.: "Computer-assisted complete three-dimensional reconstruction of the mammary ductal/lobular systems. Implications of ductal anastomoses for breast-conserving surgery"Cancer. 91. 2263-2272 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Watanabe T, et al.: "Sentinel node biopsy with technetium-99m colloidal rhenium sulphide in patients with breast cancer"Br J Surg. 88. 704-707 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ohtake T, et al.: "Computer Assisted Complete Three-dimensional Reconstruction of Multiple Breast Carcinomas. Pathological Analysis on Discrimination between Multicentric and Multifocal Tumors"Breast Cancer Research and Treatment. (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 大竹 徹: "コンピューター支援下3次元再構築による乳房内全乳管腺葉系の解剖学的検討"乳癌の臨床. 15(5). 610-611 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kimijima I, et al.: "Scattered fat invasion : an indication for poor prognosis in premenopausal, and for positive estrogen receptor in postmenopausal breast cancer patients"Oncology. 59. 25-30 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Ohtake T, et al.: "Three-dimensional reconstruction of the whole breast duct/lobular units"Breast Cancer Research and Treatment. 64(1). 104 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Ohtake T, et al.: "Giant mammary hamartoma diagnosed by stereomicroscopic analysis of the mammary glandular tree in an adolescent girl : report of a case"Surgery Today. 31. 433-437 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Ohtake T, et al.: "Computer-assisted complete three-dimensional reconstruction of the mammary ductal/lobular systems. Implications of ductal anastomoses for breast-conserving surgery"Cancer. 91. 2263-2272 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Watanabe T, et al.: "Sentinel node biopsy with technetium-99m colloidal rhenium sulphide in patients with breast cancer"British Journal of Surgery. 88. 704-707 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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