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Bisphosphonate incadronate prevents total gastrectomy-induced osteopenia in rats

Research Project

Project/Area Number 13671257
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionJikei University School of Medicine

Principal Investigator

SUZUKI Yutaka  Jikei University School of Medicine, Lecturer, 医学部, 講師 (20241060)

Co-Investigator(Kenkyū-buntansha) ISHIBASHI Yoshio  Jikei University School of Medicine, Lecturer, 医学部, 講師 (00246373)
Project Period (FY) 2001 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2004: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2003: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2002: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2001: ¥1,200,000 (Direct Cost: ¥1,200,000)
KeywordsRat / Osteoporosis / Osteomalasia / Bisphosphonate / Osteocalcin / Total gastrectomy / Osteocalcin / Deoxypyridinoline / 胃全摘後骨障害
Research Abstract

PURPOSE : Total gastrectomy(GX) leads to osteopenia. We examined the effects of bisphosphonate incadronate(INC), a potent inhibitor of bone resorption, on bone characteristics in rats that underwent total GX. EXPERIMENTAL DESIGN : Male Wistar rats were divided into 4 groups : (1)sham-operation (n=10), (2)total GX control (n=6), (3)total GX with 0.3 mg/kg/day oral administration of INC (n=7), and (4)total GX with 3.0 mg/kg/day oral administration of INC (n=7). RESULTS : Total GX significantly impaired bone mineral density ; these effects were prevented by treatment with INC. Similarly, in GX control rats, morphometrical changes of femoral metaphysis stained with Villanueva's and Villanueva-Goldner's : bone volume, tissue volume, mineral apposition rate, labeled/bone surface, bone formation rate, osteoid volume, mineralization lag time as well as serum osteocalcin, and urinary deoxypyridinoline demonstrated simultaneous existences of both osteomalacia and osteopenia ; these impairments were also prevented by INC. However, GX-induced decrease in serum levels of calcium as well as 25-hydroxyvitamin D/24,25-dihydroxyvitamin D and the increase in 1,25-dihydroxyvitamin D were not prevented by administration of INC. CONCLUSIONS : These results enhance the understanding of unique pathophysiology of both osteomalacia and osteoporosis induced by total GX and suggest the possibility of INC preventive therapy for osteopenia in GX-treated patients.

Report

(5 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (1 results)

All 2004

All Journal Article (1 results)

  • [Journal Article] Bisphosphonate incadronate prevents total gastrectomy-induced osteopenia in rats2004

    • Author(s)
      Yutaka Suzuki
    • Journal Title

      BONE 35

      Pages: 1345-1352

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary

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Published: 2001-04-01   Modified: 2016-04-21  

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