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Molecular targetting therapy based on regulation of HER2 protein in advanced gastro-intestinal cancers

Research Project

Project/Area Number 13671313
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research Institution大分医科大学

Principal Investigator

INOMATA Masafumi  Oita University, Faculty of Medicine, Surgery I, Assistant Professor, 医学部, 講師 (60315330)

Co-Investigator(Kenkyū-buntansha) YASUDA Kazuhiro  Beppu Medical Center, Surgery, Director, 外科, 医長 (70325710)
SHIRAISHI Norio  Oita University, Faculty of Medicine, Surgery I, Associate Professor, 医学部, 助教授 (20271132)
ADACHI Yosuke  Gihu University, Faculty of Medicine, Surgery I, Professor, 医学部, 教授 (90221043)
ISHIKAWA Koichi  Oita University, Faculty of Medicine, Surgery I, Assistant Professor, 医学部, 助手 (30363550)
Project Period (FY) 2001 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2003: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2002: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2001: ¥2,200,000 (Direct Cost: ¥2,200,000)
KeywordsGastric Cancer / Peritoneal Dissemination / Molecular Targetting Therapy / HER2 / Murine Metastatic Model / 大腸癌
Research Abstract

In this study, we have clarified the possibility of clinical application of a biotherapy based on regulation of HER2 protein in patients with gastro-intestinal cancer.
(A)Retrospective clinico-pathological study :
Overexpression of HER2 protein was associated with histologic type and liver metastasis, and was a prognostic factor in patients with Well-differentiated gastric cancer.
(B)In vitro study :
Cell growth of gastric cancer cell line, NCI-N87, expressing HER2 protein, was supressed by anti-HER2 antibody.
(C)In vivo study :
Tumor growth of NCI-N87 in subcutaneous inplantation was supressed by anti-HER2 antibody. These results suggested that A new therapy using a monoclonal antibody against HER2 protein was a potential candidate for a strategy of recurrence of well-differentiated gastric cancer, and its application could be decided by examining the status of HER2 expression of resected primary tumor.

Report

(4 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] Yasuda K, Inomala M, Fujii K, Shiraishi N, Adachi Y, Kitano S: "Superficially spreading cancer of the stomach."Ann Surg Oncol. 9(2). 192-196 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 猪股雅史, 安田一弘, 白石憲男, 北野正剛: "大腸癌リンパ節微小転移-予後因子としての臨床的意義-"G.I.Research. 11(3). 27-32 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Inomata M, Shiraishi N, Adachi Y, Yasuda K, Aramaki M, Kitano S: "Gastric remnant cancer compared with primary proximal gastric cancer."Hepato-Gastroenterology. 50(50). 587-591 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yasuda K, Shiraishi N, Inomata M, Shiroshita H, Ishikawa K, Kitano S: "Clinicopathologic characteristics of early-stage mutinous gastric carcinoma."J Clin Gastroenterol. (in press). (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Shiraishi N, Adachi Y, Kitano S: "Superficially spreading cancer of the stomach."Ann Surg Oncol. 9(2). 192-196 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Inomata M, Yasuda K, Shiraishi N, Kitano S: "Clinical significance of lymphonode micrometastasis in colorectal cancer."G I Research. 11(3). 27-32 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Adachi Y, Yasuda K, Aramaki M, Kitano S: "Gastric remnant cancer compared with primary proximal gastric cancer."Hepato-Gastroenterology. 50(50). 587-591 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Inomata M, Shiroshita H, Ishikawa K, Kitano S: "Clinicopathologic characteristics of early-stage mucinous gastric carcinoma."J Clin Gastroenterol. (in press). (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yasuda K: "Superficially spreading cancer of the stomach"Ann Surg Oncol. 9(2). 192-196 (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] 猪股雅史: "大腸癌リンパ節微小転移-予後因子としての臨床的意義-"G.I.Research. 11(3). 27-32 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Inomata M: "Gastric remnant cancer compared with primary proximal gastric cancer"Hepato-Gastroenterology. 50(50). 587-591 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 猪股雅史: "悪性腫瘍への腹腔鏡下手術の現況"外科治療. 90(1). 7-13 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] 猪股雅史: "高齢者胃癌診療の変遷-外科から-"老年消化器病. (in press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yasuda K: "Clinicopathologic characteristics of early-stage mucinous gastric carcinoma"J Clin Gastroenterol. (in press). (2004)

    • Related Report
      2003 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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