| Project/Area Number |
13671327
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Digestive surgery
|
|---|
| Research Institution | Kyoto Prefectural University of Medicine |
|---|
Principal Investigator |
OTSUJI Eigo Kyoto Prefectural University of Medicine, School of Medicine, Department of Surgery, Assistant Professor, 医学部, 講師 (20244600)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
OKAMOTO Kazuma Kyoto Prefectural University of Medicine, School of Medicine, Department of Surgery, Assistant Professor, 医学部, 助手 (20285258)
|
|---|
| Project Period (FY) |
2001 – 2002
|
| Project Status |
Completed (Fiscal Year 2002)
|
| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2002: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2001: ¥2,600,000 (Direct Cost: ¥2,600,000)
|
|---|
| Keywords | MONOCLONAL / ANTIBODY / A7 / PANCREATIC CANCER / SUPERPARAMAGNETIC IRON OXIDE |
|---|
| Research Abstract |
We examined the retaining in vitro immunoreactivity of superparamagnetic iron oxide (SPIO) bound to Mab A7 and their in vivo distribution in nude mice bearing human pancreatic carcinoma xenografts were examined. A7-SPIO retained binding activities nearly identical to Mab A7. Significantly more of the radiolabeled A7-SPIO and ^<125>I labeled normal mouse IgG-SPIO disappeared from blood rapidly. As for all resected normal tissues, the accumulation levels of ^<125>I labeled A7-SPIO were lower than those for the tumors and decreased linearly with time. In MR imaging of the tumor bearing mude mice, signal intensity was reduced by the injection of A7-SPIO for the tumor
|
