| Project/Area Number |
13671334
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kitasato University |
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Principal Investigator |
YOSHIDA Muneki Kitasato Univ. School of Medicine, Dept. of Surgery, Assistant Professor, 医学部, 講師 (50201017)
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| Co-Investigator(Kenkyū-buntansha) |
FURUTA Kazunori Kitasato Univ. School of Medicine, Dept, of Surgery, Research Associate, 医学部, 助手 (40209177)
TAKAHASHI Tsuyoshi Kitasato Univ. School of Medicine, Dept. of Surgery, Assistant Professor, 医学部, 講師 (70245405)
KAKITA Akira Kitasato Univ. School of Medicine, Dept. of Surgery, Professor, 医学部, 教授 (90109439)
SHIMADA Ken Kitasato Univ. School of Medicine, Dept, of Surgery, Research Associate, 医学部, 助手 (60216059)
HOSHINO Hiroki Kitasato Univ. School of Medicine, Dept. of Surgery, Research Associate, 医学部, 助手 (80276097)
板橋 浩一 北里大学, 医学部, 助手 (50265659)
木村 徹 北里大学, 医学部, 助手 (20255342)
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| Project Period (FY) |
2001 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2003: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2002: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2001: ¥1,100,000 (Direct Cost: ¥1,100,000)
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| Keywords | liver regeneration / pancreatic hormones / predictive indexes / liver failure / 耐術能 / 肝不全 / 肝再生 / 手術侵襲 / 肝機能 / 膵切除 / 肝切除 / 術後肝不全 / サイトカイン / 血漿アミノ酸 / 顆粒球エラスターゼ / 分枝鎖アミノ酸 |
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| Research Abstract |
In this study, we performed hepatectomy with pancreatectomy to assess the physiological contribution of the pancreas, especially in terms of endocrine function to hepatic regeneration. -five dogs were divided into the following four groups, group1 dogs underwent 70% hepatectomy alone, group2 dogs underwent with 66% pancreatectomy, group3 dogs underwent with 80% pancreatectomy, group4 dogs underwent with 95% pancreatectomy. While 4 week survival rate of the group1 was 100%, the survival rate decreased significantly in group2-4. The liver regeneration rate in group2,3 and 4 were also lower than those in group1. Changes on pancreatic hormones, such as insulin and glucagon, in a portal blood after the simultaneus resection of the liver and the pancreas depended on the size of the resected pancreas. Glucagon levels in the portal blood were especially increased in the group of hepatectomy with pancreatectomy. These results show that the pancreatic hormones affect the liver regeneration after the operation. In clinical practice, large scale simultaneous hepatectomy and pancreatectomy carries a high risk of postoperative hepatic insufficiency. Our present findings nay contribute to establishing prophylactic administration of glucagon and insulin to help stimulate the hepatic regeneration after evisceration.
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