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Detection of bronchial squamous dysplasia using high magnification bronchovideoscopy and angiogenesis of multi step carcinogenesis of squamous cell carcinoma

Research Project

Project/Area Number 13671376
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionChiba University

Principal Investigator

SHIBUYA Kiyoshi  Chiba University, University Hospital, Lecturer, 医学部附属病院, 講師 (20302565)

Co-Investigator(Kenkyū-buntansha) SEKINE Yasuo  Chiba University, Graduate School of Medicine, Assistant, 大学院・医学研究院, 助手 (70312957)
IIZASA Toshihiko  Chiba University, Graduate School of Medicine, Associate Professor, 大学院・医学研究院, 助教授 (10272303)
FUJISAWA Takehiko  Chiba University, Graduate School of Medicine, Professor, 大学院・医学研究院, 教授 (80110328)
斎藤 幸雄  千葉大学, 大学院・医学研究院, 講師 (60261905)
馬場 雅行  千葉大学, 大学院・医学研究院, 助教授 (00143305)
Project Period (FY) 2001 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2003: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 2002: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2001: ¥2,300,000 (Direct Cost: ¥2,300,000)
Keywordshigh-magniftcationbronchovideoscopy / bronchial dysplasia / multi step carcinogenesis / neovascularization
Research Abstract

The purpose of this study was to investigate the value of high-magnification bronchovideoscopy in detailed examination of dysplasia in the bronchial mucosa of patients exhibiting abnormal mucosal fluorescence. A high-magnification bronchovideoscope (XBF 200HM2) was used in this study. A total of 31 patients with sputum cytology suspicious or positive for malignancy were entered into the study. Conventional white-light examination was first performed on patients under local anesthesia. Fluorescence bronchoscopic examination was also caned out using a LIFE lung-system. Then, high-magnification observation was performed by high-magnification bronchovideoscopy primarily at sites of normal and abnormal fluorescence to examine the microvascular network in the bronchial mucosa. Images obtained by high-magnification bronchovideoscopy were compared with pathological diagnoses from bronchial biopsy specimens. For the vascular patterns obtained by high-magnification bronchovideoscopy, vascular ar … More ea ratios were calculated using an image-analyzing apparatus and compared. Mascular networks with regular patterns were observed in 20 of 22 abnormal fluorescence sites with bronchitis. However, vascular networks with increased vessel growth and complex networks of tortuous vessels of various sizes were observed in 15 of 21 abnormal fluorescence sites with dysplasia. There was a significant difference between bronchitis and dysplasia (OR-25, 95%CI, 5.5 to 113, p<0.0001). Vascular area ratios with the means (95% confidence interval [CI])from the 16 normal bronchial epithelium at sites of normal fluorescence, 22 bronchitis and 21 dysplasia at sites of abnormal fluorescence, were 0.054 (95%CI=0.039 to 0.07), 0.095 (95%CI=0.072 to 0.118), and 0.173 (95%CI=0.143 to 0.203), respectively. The results indicated a statistically significant increase in vascular area values in the three group (p <0.0001). Our results showed that areas of increased vessel growth and complex networks of tortuous vessels in the bronchial mucosa detected by high magnification bronchovideoscope at sites of abnormal fluorescence may allow for discrimination between bronchitis and dysplasia Less

Report

(4 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] 渋谷 潔, 廣島健三, 藤澤武彦他: "病理からみた喫煙の影響"日本医師会雑誌. 127.7. 1041-1044 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 渋谷 潔, 藤澤武彦他: "蛍光気管支内視鏡"呼吸. 21.5. 405-410 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Shibuya K, Hoshino N, Chiyo M, 他: "Subepitheial vascular patterns in bronchial dysplasias using a high magnification bronchovideoscope"Thorax. 57.10. 902-907 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kobayashi M, Shibuya K, Fujisawa T.: "Spectroscopic analysis of the autofluorescence from human bronchus using an ultraviolet laser diode"J Biomed Opt.. 7.10. 603-608 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Iyoda A, Shibuya K, 他: "A new thin-type bronchoscope improves diagnostic accuracy of peripheral pulmonary carcinoma."Oncol Rep. 10. 387-389 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Shibuya K, Hoshino H, Chiyo M, Yasufuku K, Iizasa T, Saitoh Y, Baba M, Hiroshima K, Ohwada H, Fujisawa T.: "Subepithelial vascular patterns in bronchial dysplasias using a high magnification bronchovideoscope."Thorax. 57. 902-907 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 渋谷 潔, 星野英久, 千代雅子, 藤澤武彦: "前癌病変と蛍光気管支鏡"臨床医. 29. 506-508 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Iyoda A, Shibuya K, 他: "A new thin-type bronchoscope improves diagnostic accuracy of peripheral pulmonary carcinoma."Oncol Rep. 10. 387-389 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 渋谷 潔, 高野浩昌, 廣島健三, 藤澤武彦, 大和田英美: "病理からみた喫煙の影響"日本医師会雑誌. 127・7. 1041-1044 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 渋谷 潔, 藤澤武彦, 馬場雅行, 他: "肺癌診断のための気管支鏡"臨床と研究. 79・5. 29-32 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 渋谷 潔, 藤澤武彦, 星野英久, 千代雅子: "蛍光気管支内視鏡"呼吸. 21・5. 405-410 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 渋谷 潔, 藤澤武彦, 星野英久, 千代雅子: "蛍光気管支内視鏡"日本臨床 肺癌の診断と治療-最新の研究動向-. 60・増刊5. 184-187 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Shibuya K, Hoshino H, Chiyo M, 他: "Subepithelial vascular patterns in bronchial dysplasias using a high magnification bronchovideoscope"Thorax. 57・10. 902-907 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kobayashi M, Shibuya K, Hoshino H, Fujisawa T: "Spectroscopic analysis of the autofluorescence from human bronchus using an ultraviolet laser diode. 2002;7:603-8"J Biomed Opt.. 7・10. 603-608 (2002)

    • Related Report
      2002 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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