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Boron neutron capture therapy for malignant glioma in the combination of BSH and BPA

Research Project

Project/Area Number 13671438
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionThe University of Tokushima

Principal Investigator

KAGEJI Teruyoshi  The University of Tokushima, School of Medicine, Assistant Professor, 医学部附属病院, 講師 (70294684)

Co-Investigator(Kenkyū-buntansha) INAGAWA Yoshinobu  Nationl Kagawa Children's Hospital Vice President, 副院長
NAGAHIRO Shinji  The University of Tokushima, School of Medicine, Professor, 医学部, 教授 (60145315)
堀口 英久  徳島大学, 医学部, 助手 (40304505)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2002: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2001: ¥1,800,000 (Direct Cost: ¥1,800,000)
KeywordsBNCT / malignant glioma / BSH / BPA
Research Abstract

The present report evaluates as a coperative study in Europe and Japan the pharmacokinetics and boron uptake of sodium borocaptate (BSH) and p-dihydroxyboryl phenylalanine (BPA), which has been introduced clinically as a boron carrier for boron neutron capture therapy (BNCT) in patients with glioblastoma.
First, we evaluated the BSH pharmacokinetics and boron uptake clmically in 56 patients with glioblastoma after BSH intravenous infusion. For BNCT with BSH after intravenous infusion, The pharmacokinetics and boron uptake study confirm that the planned neutron irradiation after intravenous BSH infusion appears to be optimal around 12-19 hours after the infusion.
Second, we analyzed the subcellular biodistrubution of BSH in a rat glioma model using immunohistichemical approach in a C6 glioma model.
The Wister rats were used for this experiment. An intracerebral injection of 5.0 x 106 C6 glioma cells was introduced into the region of cerebral hemishere. Fifty mg 10B/kg BSH was infused to the rats intravenously two weeks after implantation. Host rats were divided into six groups according to the sampling time: 1hr, 4hrs, 8hrs, 16hrs, 24hrs, 48hrs. After the start of BSH infusion, Immunohistochemical study was carried out using anti-BSH antibody. Boron was already found in a whole cell one hour after BSH infusion, and then seemed to collect in cell nuclei around eight to 16 hours after infusion. It was recognized in tumor cells still 48 hours after infusion.
In the case of BPA, it has been reported that neutron radiation is optimal after 1 hour after BPA infusion. This study lead that BSH is infused 12-15 hours before, and BPA is infused 1 hour before neutron irradiation to achieve the optimal clinical results in the combination of BSH and BPA.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (15 results)

All Other

All Publications (15 results)

  • [Publications] Teruyoshi Kageji: "Optimal timing of neutron irradiation for boron neutron capture therapy after intravenous infusion of sodium borocaptate in patients with glioblastoma"Int.J.Radiation Oncology Biol.Phys.. 51. 120-130 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T.Kageji: "Clinical review of BNCT using mixed neutron beam in patients with malignant glioma"Research and Development in Neutron Capture Therapy. 8-13. 1085-1091 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 影治照喜: "悪性神経膠腫に対する混合ビームを用いた中性子捕捉療法"放射線療法. 12. 421-425 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T.Kageji: "Subcellular biodistribution of socium borocaptate(BSH : Na_2B_<12>H_<11>SH) in a rat glioma model in boron neutron capture therapy"Journal of Neuro-Oncology. 59. 135-142 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T.Kenji, S.Nagahiro, K.Kitamura, Y.Nakagawa, H.Hatanaka, D.Haritz, F.Grochila, K.Haselsberger, D.Gabel: "Optimal timing of neutron irradiation for boron neutron capture therapy after intravenous infusion of sodium borocaptate in patients with glioblastoma"Int. J. Radiation Oncology Biol. Phys.. 51. 120-130 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T.Kageji, S.Nagahiro, S.Uyama, Y.Mizobuchi, K.Kitamura, Y.Nakagawa: "Clinical review of BNCT using mixed neutron beam"Research and Development in Neutron Capture Therapy. 8-13. 1085-1091 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T.Kageji, S.Nagahiro, S.Uyama, Y.Mizobuchi, K.Kitamura, Y.Nakagawa: "Boron neutron capture therapy using mixed neutron bean in patients with malignant glioma"Neutron Capture. 12. 421-425 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T.Kageji, S.Nagahiro, B.Otersen, D.Gabel, M.Nakaichi, Y.Nakagawa: "Subcellular biodistribution of sosium borocaptate (BSH: Na_2B_<12>H_<11>SH) in a rat glioma model in boron neutron capture therapy"Jounal of Neuro-Oncology. 59. 135-142 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T.Kageji: "Clinical review of BNCT using mixed neutron beam in patients with malignant glioma"Research and Development in Neutron Capture Therapy. 8-13. 1085-1091 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 影治照喜: "悪性神経膠腫に対する混合ビームを用いた中性子捕捉療法"放射線療法. 12. 421-425 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] T.Kageji: "Subcellular biodistribution of socium borocaptate (BSH : Na_2B_<12>H_<11>SH) in a rat glioma model in boron neutron capture therapy"Journal of Neuro-Oncology. 59. 135-142 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Teruyoshi Kageji: "Optimal timing of neutron irradiation for boron neutron capture therapy after intravenous infusion of sodium borocaptate in patients with glioblastoma"Int.J.Radiation Oncology Biol.Phys.. 51. 120-130 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Teruyoshi Kageji: "Frontiers in Neutron Capture Therapy, edited by Hawthorne et al.Kluwer Academic/Plenum Publishers"SUBCELLULAR BIODISTRIBUTION OF NA_2B_<12>H_<11>SH(BSH)IN RAT GLIOMA MODEL. 5 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Teruyoshi Kageji: "Frontiers in Neutron Capture Therapy, edited by Hawthorne et al.Kluwer Academic/Plenum Publishers"MEMBRANE BINDING OF NA_2B_<12>H_<11>SH(BSH)WITH PHOSPHATIDYL-CHOLINE IN BORON NEUTRON CAPTURE THERAPY. 6 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Teruyoshi Kageji: "Frontiers in Neutron Capture Therapy, edited by Hawthorne et al.Kluwer Academic/Plenum Publishers"DETERMINATION OF NA_2B_<12>H_<11>SH(BSH)ABSORBED IN TUMOR TISSUE. 5 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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